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Hydroxyethyl starch injection and preparation method thereof

A technology of hydroxyethyl starch and injection, which is applied in the direction of blood diseases, medical formulas, and extracellular fluid diseases, etc., can solve problems such as the influence of blood coagulation system, limited application, hyperchloremic metabolic acidosis, etc., and achieve the reduction of protein Effects of consumption, improvement of water and electrolyte balance, concentration of molecular distribution

Active Publication Date: 2012-04-04
辽宁海神联盛制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The average action time of 6% (480 / 0.7) is 24h, and the defect in performance is that it affects the blood coagulation system and accumulates in the body, and its high price ($43 / 500ml 6% 480 / 0.7) thus limits its use in clinical application
CN1235833A, CN1195527A announced the injection of hydroxyethyl starch, which is composed of hydroxyethyl starch and sodium chloride, but when it is used, it has the disadvantage of easily causing hyperchloric metabolic acidosis

Method used

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  • Hydroxyethyl starch injection and preparation method thereof
  • Hydroxyethyl starch injection and preparation method thereof
  • Hydroxyethyl starch injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Injection composition (calculated per 100ml injection):

[0025]

[0026] (1) Take hydroxyethyl starch 130 / 0.4, sodium chloride, potassium chloride, calcium chloride, glucose and sodium acetate of prescription quantity, mix, add water for injection and dissolve completely;

[0027] (2) Activated carbon adsorption: add 0.1% activated carbon for needle decolorization, boil for 20 minutes, adjust the pH value to 6.5-7.0;

[0028] (3) Fine filtration: use a microporous filter membrane with a diameter of 0.45um; fill; sterilize at 115°C for 30 minutes; light inspection, packaging; to obtain an injection.

Embodiment 2

[0030] Injection composition (calculated per 100ml injection):

[0031]

[0032] The preparation method is the same as in Example 1.

Embodiment 3

[0034] Injection composition (calculated per 100ml injection):

[0035]

[0036] The preparation method is the same as in Example 1.

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Abstract

The present invention provides a hydroxyethyl starch 130 / 0.4 sodium chloride injection, wherein the injection uses hydroxyethyl starch 130 / 0.4 as the main raw material, and further contains sodium chloride, potassium chloride, calcium chloride, glucose and sodium acetate. (1) The injection has the reasonable formula, and the capacity expanding time of the hydroxyethyl starch 130 / 0.4 injection of the invention and the stay time in vivo is better than that of the hydroxyethyl starch injection of the prior art. (2) The injection has well stability, and the injection property, the clarity and thecontent and the stabilization of the molecular weight of the hydroxyethyl starch 130 / 0.4 can also be kept for long time preservation. (3) The injection has the short capacity expanding time and takesfast effect in the treatment of hemorrhagic shock. (4) The injection is more approaching to the human body internal environment, is propitious to regulate the body fluid, balance the electrolyte, andreduce the damage to the liver and kidney function.

Description

technical field [0001] The invention relates to a hydroxyethyl starch injection used as a plasma substitute and a preparation method and application thereof, in particular to a hydroxyethyl starch (130 / 0.4) injection. It belongs to the field of medicine. Background technique [0002] Since the 1930s, gelatin colloidal plasma came out, and it has a history of nearly 80 years. Synthetic polyvinylpyrrolidone (PVP) was invented during World War I, Dextran (Dextran) synthesized by microorganisms appeared in World War II, and Hydroxyethyl Starch (HES) was developed in the United States in the mid-1970s. Dextran and hydroxyethyl starch were successfully researched in 1958 and 1967 respectively by China Peking Union Medical College and Institute of Blood Transfusion and Blood Research, Chinese Academy of Medical Sciences, and quickly formed industrialization in my country, which has a low impact on prevention and treatment in our country. Blood volume and shock patients played a maj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K31/718A61K9/08A61P7/08A61K31/19A61K31/7004
Inventor 万鹏韦家华
Owner 辽宁海神联盛制药有限公司
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