Oil-in-water compound star anise oil nanoemulsion oral liquid and preparation method thereof

A technology of star anise oil and emulsion oral liquid, which is applied in the field of medicine, can solve the problems of poor oral absorption effect, inconvenience for patients to take, and low content of active ingredients, and achieve good dispersion of emulsion droplets, good solubilization, The effect of improving solubility

Inactive Publication Date: 2012-04-04
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these methods can also cure the disease, their active ingredient content is low, the stability is poor, the oral absorption effect is not good, and the preparation process is complicated, the cost is high, and it is inconvenient for patients to take it.

Method used

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  • Oil-in-water compound star anise oil nanoemulsion oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Weigh 29.7g RH-40, 1.7g absolute ethanol, 6.4g star anise oil, 2.6g cinnamon oil, 2.3g ginger oil, 1.3g fenugreek oil, 0.8g ginsenoside, 55.2g distilled water, set aside;

[0052] (2) Stir the star anise oil, cinnamon oil, ginger oil and fenugreek oil evenly as the oil phase;

[0053] (3) Add ginsenosides into distilled water and stir until completely dissolved, as the water phase;

[0054] (4) Add the surfactant and co-surfactant into the oil phase and mix well;

[0055] (5) Use distilled water as the water phase, stir the oil phase rapidly at room temperature, slowly add the water phase dropwise while stirring, and keep stirring until the system becomes a transparent liquid, and the oil-in-water compound star anise oil nanoemulsion oral liquid is obtained.

Embodiment 2

[0057] EL-40 30.2g Ginger Oil 2.3g

[0058] 1,2-Propanediol 1.2g Patchouli Oil 1.5g

[0059] Star Anise Oil 5.7g Ginsenosides 0.8g

[0060] Cinnamon Oil 1.8g Distilled Water 56.5g.

Embodiment 3

[0062] Tween-80 26.1g Ginger Oil 3.0g

[0063] Glycerin 2.9g Patchouli Oil 1.7g

[0064] Star Anise Oil 8.8g Ginsenosides 1.3g

[0065] Cinnamon Oil 3.9g Distilled Water 52.3g.

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PUM

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Abstract

The invention discloses oil-in-water compound star anise oil nanoemulsion oral liquid. The grain size of the nanoemulsion oral liquid is 1 to 10nm, and the oral liquid consists of the following raw materials in percentage by mass: 25.0 to 35.0 percent of surfactant, 0.3 to 4.0 percent of cosurfactant, 1.8 to 10.0 percent of star anise oil, 0.7 to 6.0 percent of cinnamon oil, 0.5 to 5.0 percent of ginger oil, 0.3 to 4.0 percent of costus root oil, 0.2 to 2.0 percent of panaxoside, and the balance of distilled water, and the sum of the mass percentages of the raw materials is 100 percent. The nanoemulsion oral liquid has the effects of warming the kidney and dispersing cold, strengthening the spleen and stomach, removing obstruction, smoothing circulation and stopping pains, eliminating ventosity, and promoting digestion, is high in stability and oral bioavailability, and has an obvious effect, action time is long, a preparation method is simple, and the oral liquid is convenient to popularize and has very large application prospect in a medicinal market.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a compound star anise oil nanoemulsion oral liquid with the functions of warming the kidneys and dispelling cold, invigorating the spleen and harmonizing the stomach, regulating qi and relieving pain, eliminating flatulence and promoting digestion and a preparation method thereof. Background technique [0002] In daily life, spleen and stomach deficiency and indigestion are common diseases. Although they are not life-threatening, they always plague our bodies and make us unable to carry out normal work, life and study. According to statistics, about 30% to 40% of people around the world suffer from such diseases. The main cause of spleen and stomach deficiency is poor eating habits such as intemperance, frequent eating of cold drinks or cold food. Coupled with the fast pace of life and high mental stress, it is more likely to cause stomach problems. At present, the clinical methods for tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/107A61P1/14A61P29/00A61P1/08
Inventor 欧阳五庆郑星星孙江宏
Owner NORTHWEST A & F UNIV
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