Nisoldipine liposome solid preparation

A solid preparation, dipine fat technology, applied in the field of medicine, can solve the problems of low bioavailability, long dissolution time, many times of taking medicine, etc., and achieve the effects of high bioavailability, good sustained-release effect, and excellent dissolution.
CN102406608AInactive Publication Date: 2012-04-11HAINAN MEILAN SMITH KLINE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HAINAN MEILAN SMITH KLINE PHARMA
Publication Date
2012-04-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a nisoldipine liposome solid preparation and a preparation method thereof. The liposome is prepared from an active component nisoldipine and specifically combined phosphatidyl ethanolamine, phosphatidylcholine distearate, acetyl cholesterol and tween 80, so that the stability, solubility and bioavailability of the medicament can be greatly improved, the action is smooth and durable, and the curative effect is remarkable. According to the preparation, the product quality of the preparation is increased, and toxic and side effects are reduced.
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Description

technical field

[0001] The invention relates to a new preparation of nisoldipine, in particular to a nisoldipine liposome and its solid preparation and preparation method, and belongs to the technical field of medicine. Background technique

[0002] Cardiovascular and cerebrovascular disease is one of the diseases with the highest morbidity and mortality in the world today. It is the primary cause of death and the number one killer of health. The incidence of cardiovascular system diseases in my country is basically the same as that in the world. In the 1960s, the cause of death has risen from the seventh to the first. Every year, 3 million people die due to cardiovascular and cerebrovascular diseases, and 10 million people are disabled due to cardiovascular and cerebrovascular diseases. Almost every cardiovascular and cerebrovascular patient has clinical symptoms of elevated blood pressure and needs antihypertensive treatment. The market for antihypertensive drugs is huge. ...

Claims

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