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Preparation method of cough-relieving Sichuan fritillary bulb-loquat particles

A technology for treating cough Chuanbei loquat and granules, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of high storage and transportation conditions, large doses taken by patients, and influence on the treatment effect, and achieves convenience for storage and transportation, small drug dosage, Facilitate the effect of quantitative administration

Inactive Publication Date: 2012-04-11
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above extraction methods cannot fully extract the active ingredients, and the bioavailability is low, which affects the efficacy of the drug and directly affects the therapeutic effect. The patient takes a large dose, which is not suitable for quantification, and there are deficiencies in high requirements for storage and transportation conditions.

Method used

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  • Preparation method of cough-relieving Sichuan fritillary bulb-loquat particles
  • Preparation method of cough-relieving Sichuan fritillary bulb-loquat particles

Examples

Experimental program
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Effect test

Embodiment 1

[0016] A preparation method of Chuanbei loquat granules for treating cough, comprising the following steps:

[0017] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0018] (2) Decoct the loquat leaves with water for 2 times, filter, the quality of water added each time is 6 times of the quality of the loquat leaves, and the decoction time is 3 hours, and the filtrate is combined and concentrated to a clear liquid with a relative density of 1.30 at 70°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 8 hours, take the supernatant, and set aside.

[0019] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of adding ethanol is 6 times of the quality of flat fritillaria, platycodon grandiflorum and water pinellia, extracted The tim...

Embodiment 2

[0022] A preparation method of Chuanbei loquat granules for treating cough, comprising the following steps:

[0023] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0024] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 8 times of the quality of loquat leaves, decocting time is 2 hours, combine the filtrate, concentrate to the clear liquid with a relative density of 1.30 at 60°C paste, add ethanol with 3 times the volume of the clear paste, fully stir, let stand for 10 hours, take the supernatant, and set aside.

[0025] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of ethanol added each time is 5 times of the quality of flat fritillaria, platycodon grandiflora and water pinellia, extracted The time is 2 hours; the filtr...

Embodiment 3

[0028] A preparation method of Chuanbei loquat granules for treating cough, comprising the following steps:

[0029] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0030] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 3 times of the quality of loquat leaves, decocting time is 4 hours, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.30 at 75°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 6 hours, take the supernatant, and set aside.

[0031] (3) Pulverize the flat fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and Pinellia syringae, filter, and the quality of adding ethanol each time is 7 times of the quality of Fritillaria chinensis, platycodon grandiflorum and pinellia water, extract The time is 2 hour...

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Abstract

The invention discloses a preparation method of cough-relieving Sichuan fritillary bulb-loquat particles. The preparation method consists of the following steps of: (1) weighing raw materials; (2) adding water into loquat leaves for decocting, filtering, concentrating into clear paste, adding ethanol, fully stirring, standing, and extracting a supernate for later use; (3) smashing ussuriensis fritillary bulb, performing heat reflux extraction on the smashed ussuriensis fritillary bulb, platycodon root and typhonium flagelliforme with ethanol, filtering, combining the filtrate with the supernate obtained in the step (2), recovering the ethanol, concentrating to clear paste, naturally cooling to the room temperature, adding butanone for extracting, recovering the butanone, and concentrating to thick paste; and (4) uniformly mixing the thick paste with cane sugar, starch or dextrin of which the mass is 1-5 times that of the thick paste, pelletizing, and drying to obtain the Sichuan fritillary bulb-loquat particles. The cough-relieving Sichuan fritillary bulb-loquat particles prepared from raw materials extracted with an extraction method disclosed by the invention have the advantages of small medicament dosage, high content, convenience for taking and carrying, good curative effect, and contribution to quantitative taking, storage and transportation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Chuanbei loquat granules for treating cough. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. It has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above extraction methods cannot fully extract the active ingredients, and the bi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/16A61P11/14
Inventor 刘丹刘俊静佟永领
Owner 津药达仁堂集团股份有限公司第六中药厂