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Preparation method of fritillary and loquat dripping pills for treating cough

A technology for treating cough with Chuanbei loquats and dropping pills, which is applied in the directions of medical preparations containing active ingredients, pill delivery, pharmaceutical formulations, etc. To improve the ability to seek medical treatment, improve the overall health level, and achieve the effect of high drug content

Active Publication Date: 2012-04-11
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above extraction methods cannot fully extract the active ingredients, thereby affecting the efficacy of the drug and directly affecting the therapeutic effect.
The disadvantages of the above-mentioned dosage forms are: after taking Chuanbei Pipalu for Cough, there is a first-pass effect in the liver, and the bioavailability is low, which affects the efficacy of the medicine and directly affects the therapeutic effect. The preparation contains sugar, which is not conducive to Patients with high blood sugar take it, the dosage is large, it is not suitable for quantification, and there are deficiencies in the requirements for storage and transportation conditions

Method used

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  • Preparation method of fritillary and loquat dripping pills for treating cough
  • Preparation method of fritillary and loquat dripping pills for treating cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of Chuanbei loquat dropping pills for treating cough is composed of the following steps:

[0018] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0019] (2) Decoct the loquat leaves with water for 2 times, filter, the quality of water added each time is 6 times of the quality of the loquat leaves, and the decoction time is 3 hours, and the filtrate is combined and concentrated to a clear liquid with a relative density of 1.30 at 70°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 8 hours, take the supernatant, and set aside.

[0020] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of adding ethanol is 6 times of the quality of flat fritillaria, platycodon grandiflorum and water pinellia, extracted...

Embodiment 2

[0023] A preparation method of Chuanbei loquat dropping pills for treating cough is composed of the following steps:

[0024] (1) Weigh raw materials: 6.8g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0025] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 8 times of the quality of loquat leaves, decocting time is 2 hours, combine the filtrate, concentrate to the clear liquid with a relative density of 1.30 at 60°C paste, add ethanol with 3 times the volume of the clear paste, fully stir, let stand for 10 hours, take the supernatant, and set aside.

[0026] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of ethanol added each time is 5 times of the quality of flat fritillaria, platycodon grandiflora and water pinellia, extracted The time is 2 hours;...

Embodiment 3

[0028] A preparation method of Chuanbei loquat dropping pills for treating cough is composed of the following steps:

[0029] (1) Weigh raw materials: 6.8g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0030] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 3 times of the quality of loquat leaves, decocting time is 4 hours, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.30 at 75°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 6 hours, take the supernatant, and set aside.

[0031] (3) Pulverize the flat fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and Pinellia syringae, filter, and the quality of adding ethanol each time is 7 times of the quality of Fritillaria chinensis, platycodon grandiflorum and pinellia water, extract The time...

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Abstract

The invention discloses a preparation method of fritillary and loquat dripping pills for treating cough, comprising the following steps of: (1) weighing raw materials; (2) decocting loquat leaf with water, filtering, concentrating to obtain clear paste, adding ethanol, fully mixing, standing, taking supernatant for later use; and (3) pulverizing fritillary bulb, performing hot reflux extraction with ethanol on the fritillary bulb powder, balloonflower and typhonium flagelliforme, filtering, combining the filtrate with the supernatant obtained in the step (2), recycling the ethanol, concentrating to obtain clear paste, cooling to room temperature, adding butanone for extraction, recycling the butanone and concentrating to obtain thick paste; heating a substrate for melting, adding the thick paste, stirring uniformly, adding menthol and mixing uniformly, and dripping to prepare dripping pills. The dripping pills disclosed by the invention have high drug content, small volume and high dissolution rate, are taken sublingually, can effectively avoid the first pass effect, have no stimulating side effect on gastrointestinal tracts, do not contain sugar, are conductive to quantitative administration and are convenient to store and transport.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Chuanbei loquat dropping pills for treating cough. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. Has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above-mentioned extraction method cannot fully extract the active ingredients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61P11/14A61P11/10
Inventor 刘丹刘俊静佟永领
Owner 津药达仁堂集团股份有限公司第六中药厂