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Method for preparing fritillary and loquat tablets for treating cough

A technology of loquat tablets and Chuanbei, which is applied in the field of preparation of cough-treating Chuanbei loquat tablets, can solve the problems of high requirements for storage and transportation, large doses taken by patients, and affecting the therapeutic effect, so as to facilitate storage and transportation, and improve drug dosage. Small, beneficial to the effect of quantitative administration

Inactive Publication Date: 2012-05-02
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above extraction methods cannot fully extract the active ingredients, and the bioavailability is low, which affects the efficacy of the drug and directly affects the therapeutic effect. The patient takes a large dose, which is not suitable for quantification, and there are deficiencies in high requirements for storage and transportation conditions.

Method used

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  • Method for preparing fritillary and loquat tablets for treating cough
  • Method for preparing fritillary and loquat tablets for treating cough

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0020] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0021] (2) Decoct the loquat leaves with water for 2 times, filter, the quality of water added each time is 6 times of the quality of the loquat leaves, and the decoction time is 3 hours, and the filtrate is combined and concentrated to a clear liquid with a relative density of 1.30 at 70°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 8 hours, take the supernatant, and set aside.

[0022] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of adding ethanol is 6 times of the quality of flat fritillaria, platycodon grandiflorum and water pinellia, extracted The time is 2 hours...

Embodiment 2

[0025] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0026] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0027] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 8 times of the quality of loquat leaves, decocting time is 2 hours, combine the filtrate, concentrate to the clear liquid with a relative density of 1.30 at 60°C paste, add ethanol with 3 times the volume of the clear paste, fully stir, let stand for 10 hours, take the supernatant, and set aside.

[0028] (3) The flat fritillaria is pulverized, extracted twice with ethanol hot reflux with platycodon grandiflora and water pinellia, filtered, and the quality of ethanol added each time is 5 times of the quality of flat fritillaria, platycodon grandiflora and water pinellia, extracted The time is 2 hours; the filtrate is combi...

Embodiment 3

[0031] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0032] (1) Weigh raw materials: 68g of loquat leaves, 6g of Platycodon grandiflora, 20g of pinellia chinensis, 7g of flat fritillary and 0.15g of menthol;

[0033] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 3 times of the quality of loquat leaves, decocting time is 4 hours, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.30 at 75°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 6 hours, take the supernatant, and set aside.

[0034] (3) Pulverize the flat fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and Pinellia syringae, filter, and the quality of adding ethanol each time is 7 times of the quality of Fritillaria chinensis, platycodon grandiflorum and pinellia water, extract The time is 2 hours; the filtr...

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Abstract

The invention discloses a method for preparing fritillary and loquat tablets for treating cough. The method comprises the following steps of: (1) weighing raw materials; (2) decocting loquat leaves by adding water, filtering, concentrating to obtain clear paste, adding ethanol, fully stirring, standing, and taking supernate for later use; (3) crushing fritillary bulb, performing thermal reflux extraction on the fritillary bulb powder, platycodon root and typhonium flagelliforme by using ethanol, filtering, mixing the filtrate and the supernate obtained in the (2), reclaiming the ethanol, concentrating to obtain clear paste, cooling the clear paste to room temperature, adding butanone for extracting, reclaiming the butanone, concentrating the clear paste to obtain thick paste, and drying, crushing and screening the thick paste to obtain extract powder; and (4) adding a lubricating agent and a thinning agent into the extract powder, mixing uniformly, and preparing the tablets. The cough treating fritillary and loquat tablets prepared from the raw materials extracted by the extraction method have low dose and high content, are convenient to administrate and carry, have good curative effect, and are favorable for quantitative administration and favorable for storage and transportation.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Chuanbei Piquat Tablets for Zhike. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. It has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above extraction methods cannot fully extract the active ingredients, and the bioavailabil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61P11/14A61P11/10
Inventor 刘丹刘俊静佟永领
Owner 津药达仁堂集团股份有限公司第六中药厂