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Fritillary and loquat tablet for treating cough and preparation method of fritillary and loquat tablet

The technology of loquat tablets and Chuanbei is applied in the field of preparation of traditional Chinese medicine preparations, which can solve the problems of affecting the efficacy of medicine, affecting the therapeutic effect, and not being suitable for quantification, and achieves the effect of being beneficial to storage and transportation, being beneficial to quantitative taking, and having a small dose of medicine.

Inactive Publication Date: 2012-04-11
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above extraction methods cannot fully extract the active ingredients, and the bioavailability is low, which affects the efficacy of the drug and directly affects the therapeutic effect. The patient takes a large dose, which is not suitable for quantification, and there are deficiencies in high requirements for storage and transportation conditions.
[0004] In addition, the raw material prescription contains water pinellia, which has the effect of drying dampness, resolving phlegm and relieving cough, but water pinellia is slightly poisonous.

Method used

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  • Fritillary and loquat tablet for treating cough and preparation method of fritillary and loquat tablet
  • Fritillary and loquat tablet for treating cough and preparation method of fritillary and loquat tablet
  • Fritillary and loquat tablet for treating cough and preparation method of fritillary and loquat tablet

Examples

Experimental program
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Effect test

Embodiment 1

[0022] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0023] (1) Weigh raw materials: 68g of loquat leaves, 6g of bellflower, 20g of perilla seed, 7g of flat fritillaria and 0.15g of menthol;

[0024] (2) Decoct the loquat leaves with water for 2 times, filter, the quality of water added each time is 6 times of the quality of the loquat leaves, and the decoction time is 3 hours, and the filtrate is combined and concentrated to a clear liquid with a relative density of 1.30 at 70°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 8 hours, take the supernatant, and set aside.

[0025] (3) Pulverize the flat fritillaria, extract 2 times with platycodon grandiflorum and perilla seed with ethanol heat reflux, filter, the quality of adding ethanol each time is 6 times of the mass of flat fritillaria, platycodon grandiflorum and perilla seed, extract The time is 2 hours; the filtrate is combin...

Embodiment 2

[0028] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0029] (1) Weigh raw materials: 68g of loquat leaves, 6g of bellflower, 20g of perilla seed, 7g of flat fritillaria and 0.15g of menthol;

[0030] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 8 times of the quality of loquat leaves, decocting time is 2 hours, combine the filtrate, concentrate to the clear liquid with a relative density of 1.30 at 60°C paste, add ethanol with 3 times the volume of the clear paste, fully stir, let stand for 10 hours, take the supernatant, and set aside.

[0031] (3) Pulverize the Fritillaria fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and perilla seed, filter, and the quality of adding ethanol each time is 5 times of the mass of Fritillaria fritillaria, platycodon grandiflorum and perilla seed, extract The time is 2 hours; the filtrate is combined with the su...

Embodiment 3

[0034] The preparation method of Cough Chuanbei Loquat Tablets consists of the following steps:

[0035] (1) Weigh raw materials: 68g of loquat leaves, 6g of bellflower, 20g of perilla seed, 7g of flat fritillaria and 0.15g of menthol;

[0036] (2) decoct loquat leaves with water for 2 times, filter, the quality of adding water each time is 3 times of the quality of loquat leaves, decocting time is 4 hours, combine the filtrates, and concentrate to a clear liquid with a relative density of 1.30 at 75°C. ointment, add ethanol with 3 times the volume of the clear ointment, fully stir, let stand for 6 hours, take the supernatant, and set aside.

[0037] (3) Pulverize the Fritillaria fritillaria, extract 2 times with ethanol hot reflux with platycodon grandiflorum and perilla seed, filter, and the quality of adding ethanol each time is 7 times of the mass of platytrimus fritillaria, platycodon grandiflorum and perilla seed, extract The time is 2 hours; the filtrate is combined wi...

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PUM

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Abstract

The invention discloses a fritillary and loquat tablet for treating cough and a preparation method of the fritillary and loquat tablet. The preparation method comprises the following steps of: (1) weighing raw materials; (2) adding water into loquat leaf to be decocted, filtering, condensing into clear paste, adding alcohol, fully stirring, standing, and taking supernate for later use; (3) smashing fritillary bulb, carrying out hot reflux extraction on the smashed fritillary bulb, platycodon grandiflorum and perilla fruit by using the alcohol, filtering, combining filtrate with the supernate obtained in the step (2), recovering the alcohol, condensing to the clear paste, cooling to room temperature, adding butanone for extracting, recovering the butanone, condensing into thick paste, drying the thick paste, smashing and screening; and (4) adding a lubricant and a thinning agent in extractive powder, and evenly mixing to obtain the tablet. The fritillary and loquat tablet for treating cough has the action on relieving cough, eliminating phlegm and relieving asthma. The fritillary and loquat tablet for treating cough, which is prepared from the raw materials extracted with the extraction method, has small medicine dosage, high content and good curative effect, is convenient to take and carry, is favorable for taking quantificationally and is favorable to store and transport.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to Chuanbei Piquat Tablets for Cough Treatment and the preparation method. Background technique [0002] Cough Chuanbei Pipa Dew is prepared from traditional Chinese medicine raw materials: loquat leaves, platycodon grandiflorum, water pinellia, flat fritillaria liquid extract and menthol. It has antitussive and expectorant functions. For cough caused by cold and bronchitis. Its formula is: 68g of loquat leaves, 6g of platycodon grandiflorum, 20g of water pinellia, 7ml of flat fritillaria liquid extract, 0.15g of menthol. Once, filter, combine the filtrates, concentrate to an appropriate amount, add preservatives, filter, add 682g of sucrose, add flat fritillaria liquid extract and menthol in turn, add water to adjust to 1000ml, shake well, and get ready. [0003] The above extraction methods cannot fully extract the active ingredients, and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K9/20A61P11/14A61P11/10A61P11/06
Inventor 刘俊静刘丹佟永领
Owner 津药达仁堂集团股份有限公司第六中药厂