Production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection

Abstract

The invention provides a production method of cefpirome sulfate / sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection, which comprises the following steps of: preparing liquid medicine, bagmaking and filling, sterilizing and drying, sterile split charging, and the like; and is characterized in that the bagmaking and filling comprises the following steps of: utilizing a film for multilayer coextrusion infusion to make a bag body with a solid chamber and a liquid chamber through middle pseudo soldering and periphery soldering, wherein the pseudo soldering part divides the bag body into the solid chamber and the liquid chamber; after further processing and testing the bag body, filling sodium chloride injection into the liquid chamber; and then sealing a combined cover and a port by fusing. The production method of the cefpirome sulfate / sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection has the following advantages that: the separating safety of the solid chamber and the liquid chamber is good; the operation in opening is convenient; each processing step has no adverse impact on drugs and the bag body; and the impact on the drugs and the bag body, and various test items for the produced product conform to the standard.

Description

technical field [0001] The invention relates to a production method of cefpirome sulfate / sodium chloride injection and relates to a production method of cefpirome sulfate / sodium chloride injection non-PVC ready-to-mix infusion. Background technique [0002] The double-chamber bag for infusion made according to the needs of infusion facilitates clinical use, avoids the complex operation of infusion mixing before clinical use in the prior art, and avoids the situation of wrongly mixing drugs when used in emergency situations. Reduced secondary pollution. [0003] The double-chamber bag infusion comprises the steps of preparing the double-chamber bag and then loading the injection medicine and the infusion respectively during processing. For example, the patent application whose application number is CN200610043577.6 discloses the solid-liquid double-chamber bag infusion of rabeprazole sodium for injection and its The preparation method includes a small chamber and a large cha...

AI Technical Summary

Problems solved by technology

The isolation structure adopted by these existing double-chamber bags for infusion often has problems such as poor isolation safety or inconvenient operation when opening, and does not consider the adaptability of the drug and the bag, for example, does not consider the impact of packaging and sterilization conditions on the drug. and bag effects

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