Production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection

A technology of sodium chloride injection and cefpirome sulfate, which is applied in the direction of chemical instruments and methods, layered products, liquid materials, etc., can solve the problem of not considering the compatibility of drugs and bags, not considering the impact, and isolation safety no problem

Inactive Publication Date: 2012-05-02
北京锐业制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The isolation structure adopted by these existing double-chamber bags for infusion often has problems such as poor isolation safety or inconvenient operation when opening,...

Method used

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  • Production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection
  • Production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection
  • Production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection

Examples

Experimental program
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Embodiment

[0049] Embodiment: The process steps include: preparation of liquid medicine, bag making and filling, sterilization and drying, powder injection sub-packaging, light inspection, aluminum foil welding, labeling, and pillow packaging.

[0050] 1) Preparation of medicinal solution: According to the prescription ratio and batch weighing of each raw and auxiliary material, 0.9% sodium chloride injection was prepared according to the method shown in the summary of the invention.

[0051] 2) Bag making and filling: film coating→film pulling→liquid chamber printing→virtual welding 5→peripheral welding→mouth tube 2 delivery→mouth tube 2 preheating→mouth tube 2 welding→mouth tube 2 shaping→tearing waste edge→ Bag transfer→vacuum leak detection→bag overturning and positioning→bag receiving→liquid chamber 3 filling with 0.9% sodium chloride injection solution→melt sealing of polypropylene combination cap 1 and mouth tube 2→bottom bag by manipulator to produce figure 2 The bag shown has a...

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Abstract

The invention provides a production method of cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection, which comprises the following steps of: preparing liquid medicine, bagmaking and filling, sterilizing and drying, sterile split charging, and the like; and is characterized in that the bagmaking and filling comprises the following steps of: utilizing a film for multilayer coextrusion infusion to make a bag body with a solid chamber and a liquid chamber through middle pseudo soldering and periphery soldering, wherein the pseudo soldering part divides the bag body into the solid chamber and the liquid chamber; after further processing and testing the bag body, filling sodium chloride injection into the liquid chamber; and then sealing a combined cover and a port by fusing. The production method of the cefpirome sulfate/ sodium chloride injection non-PVC (polyvinyl chloride) instant matched injection has the following advantages that: the separating safety of the solid chamber and the liquid chamber is good; the operation in opening is convenient; each processing step has no adverse impact on drugs and the bag body; and the impact on the drugs and the bag body, and various test items for the produced product conform to the standard.

Description

technical field [0001] The invention relates to a production method of cefpirome sulfate / sodium chloride injection and relates to a production method of cefpirome sulfate / sodium chloride injection non-PVC ready-to-mix infusion. Background technique [0002] The double-chamber bag for infusion made according to the needs of infusion facilitates clinical use, avoids the complex operation of infusion mixing before clinical use in the prior art, and avoids the situation of wrongly mixing drugs when used in emergency situations. Reduced secondary pollution. [0003] The double-chamber bag infusion comprises the steps of preparing the double-chamber bag and then loading the injection medicine and the infusion respectively during processing. For example, the patent application whose application number is CN200610043577.6 discloses the solid-liquid double-chamber bag infusion of rabeprazole sodium for injection and its The preparation method includes a small chamber and a large cha...

Claims

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Application Information

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IPC IPC(8): B65B3/04B65B29/06B65B1/12B65B3/02B65B55/14A61K31/546A61P31/04B32B27/06B32B27/32
Inventor 徐卫东李长宏陈秀艳牛秀鑫闫杰
Owner 北京锐业制药有限公司
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