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Copper sodium chlorophyllate tablets and preparation method thereof

A technology of sodium copper chlorophyll and filler, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as large differences in stability and limited sources of raw materials for extraction.

Active Publication Date: 2012-05-09
ZHEJIANG WAN SHENG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the limited source of extraction raw materials, most of the raw materials of sodium copper chlorophyllin at the current price are extracted from green plants and processed, and their stability is greatly different from that of early raw materials.

Method used

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  • Copper sodium chlorophyllate tablets and preparation method thereof
  • Copper sodium chlorophyllate tablets and preparation method thereof
  • Copper sodium chlorophyllate tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Since sodium copper chlorophyllin comes from silkworm excrement or green plants, it may have a strong affinity with starch or cellulose. In order to verify the adsorption of excipients, the present invention uses water-insoluble and water-soluble fillers in different proportions to formulate the excipients. of adsorption.

[0012]

[0013] Conclusion: Prescription 1 and Prescription 3 use fully soluble excipients, and there is no excipient adsorption during the preparation process. Prescription 4 has half of the insoluble excipients, and the content is obviously higher than that in Prescription 2. The above shows that the adsorption of insoluble excipients is more serious, so the present invention uses fully soluble excipients.

Embodiment 2

[0015] In the prior art, the water content of sodium copper chlorophyllin particles is more than 6%, which is the main factor affecting the reduction of sodium copper chlorophyllin content. The present invention starts with reducing the water content of the product and tests. Therefore, absolute ethanol was used as the wetting agent in the following tests to minimize the interference of moisture. Due to the high correlation between moisture and compressibility in the prescription, some excipients with better compressibility were used as much as possible in the selection of excipients, and alcohol-soluble adhesives with strong viscosity were used.

[0016] Changes in Weight Gain of Copper Chlorophyllin Sodium

[0017]

[0018] Conclusion: In the case of a relative humidity of 90%, the moisture absorption weight gain is 1.97%, which shows that the moisture absorption capacity of this product is limited, and most of the content drop under high humidity conditions is due to de...

Embodiment 3

[0020] The test prescription 091201-2 has a sticking phenomenon. Therefore, domestic lactose was used to replace half of the sucrose as filling, and magnesium stearate with good lubricating properties was used instead of talcum powder as lubricant.

[0021] ①. Prescription composition (500 tablets):

[0022] components

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PUM

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Abstract

The invention discloses copper sodium chlorophyllate tablets, which consist of copper sodium chlorophyllate, filler, adhesive, lubricating agent and disintegrating agent. The copper sodium chlorophyllate tablets are characterized in that: the filler is starch or powdered sugar; the adhesive is povidone K30; the lubricating agent is magnesium stearate; the weight percentage ratio of the copper sodium chlorophyllate, the filler, the adhesive, the lubricating agent and the disintegrating agent is 40: 90: 90: 40: 109; and the slurry for coating the copper sodium chlorophyllate tablets is selectedfrom 10 percent povidone K30 slurry prepared by using absolute ethanol. The moisture in the coating solution can be reduced, the content of the moisture brought to the coatings due to the coating solution is reduced, and the chlorophyll content of the medicament is prevented from being reduced by hydrolysis. The content of the coated tablets in 24 mouths is still in a qualified range, and the copper sodium chlorophyllate serving as a main component can be effectively prevented from being degraded.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, in particular to a sodium copper chlorophyllin tablet and a preparation method thereof Background technique [0002] Sodium copper chlorophyllin is a dark green powder with metallic luster, odorless or slightly ammoniacal, soluble in water, slightly soluble in alcohol and chloroform, almost insoluble in oil and petroleum ether; its aqueous solution is blue-green, transparent, non-toxic Precipitation, the pH value of 1% aqueous solution is 9.5-10.2. Chlorophyll and its derivatives have antibacterial, antiviral, antiallergic and tissue regeneration promoting effects. Chlorophyll copper sodium salt, iron sodium salt and cobalt sodium salt are good complex agents for hematopoietic cells, and have therapeutic effects on hematopoiesis and various anemias after radiotherapy and caused by various reasons. The mechanism of chlorophyll raising leukocytes, some studies believe that it is main...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/409A61K47/36A61K47/26A61K47/32A61K47/12A61P7/00A61P1/16
Inventor 杜军鲍黎
Owner ZHEJIANG WAN SHENG PHARMA CO LTD