Method for preparing aryl acetonitrile compound
A technology for aryl acetonitrile and compounds, applied in the field of compound synthesis, can solve the problems of tin reagent toxicity, environmental pollution, etc.
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[0085] Example 1. Preparation of 2,6-dimethylbenzeneacetonitrile:
[0086] Reaction formula:
[0087]
[0088] The specific method is as follows: add 0.75 mmol of potassium cyanoacetate in the vacuum reactor, and the molar dosage is 0.2% allyl palladium chloride (Pd 2 (p-allyl) 2 Cl 2) 0.01 mmol of catalyst and 0.03 mmol of S-Phos phosphine ligand with 0.6% molar amount of electrophilic substrate, evacuated, passed high-purity argon, replaced three times, and added 0.5 mmol of electrophilic substrate under the protection of argon flow The compound 2,6-dimethylbromobenzene and the solvent trimethylbenzene (the amount of solvent is added 2 ml of solvent per millimoles of electrophilic substrate), placed at 140 ° C, heated and stirred for 10 hours, decarboxylated according to the following method The reaction system after the coupling reaction is completed is purified to obtain the target product 2,6-dimethylphenylacetonitrile: the reaction system mixture after the reaction...
Example Embodiment
[0090] Embodiment 2, prepare phenylacetonitrile:
[0091] Reaction formula:
[0092]
[0093] The method is the same as in Example 1, and the productive rate is shown in Table 1.
Example Embodiment
[0094] Embodiment 3, preparation phenylacetonitrile:
[0095] Reaction formula:
[0096]
[0097] The method is the same as in Example 1, and the productive rate is shown in Table 1.
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