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Method for extracting arecoline from areca

A technology of arecoline and areca nut, which is applied in organic chemistry and other fields, can solve the problems of small extraction amount, unsuitability for industrial production, and large investment in supercritical extraction equipment, and achieve the effects of reducing losses, easy sewage treatment, and low cost

Inactive Publication Date: 2012-05-23
苏州宝泽堂医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The investment in supercritical extraction equipment is large, the extraction volume is small, and it is not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The raw materials of betel nut, de-nucleated and pulverized, take 5kg, add pH1 hydrochloric acid solution and permeate for 24 hours, collect 60L percolation liquid, take 4L001 × 7 strong acid styrene series cation exchange resin after treatment, pack the column, filter the percolation liquid and add Exchange adsorption, the flow rate is controlled at 2-3L / h, after saturation adsorption, wash with deionized water until neutral, eluate with 16L 4% sodium chloride solution, collect the eluate and add it to a tubular cellulose membrane system with a molecular weight cut-off of 6000. Filter, dialyze an appropriate amount of water, add the permeate to the tubular cellulose membrane with a molecular weight cut-off of 100 for nanofiltration concentration, adjust the pH of the concentrated solution to 7, pressurized distillation with a distiller, detect the thin layer until the distillation mother liquor is free of arecoline, collect fractions, freeze After drying, 11 g of arecol...

Embodiment 2

[0026] The raw materials of areca nut, de-nucleated and pulverized, take 5kg, add pH3 hydrochloric acid solution and permeate for 24 hours, collect 120L percolation liquid, take 4L001×7 strong acid styrene-based cation exchange resin for treatment and pack it into a column, filter the percolation liquid and add it. Exchange adsorption, the flow rate is controlled at 4-5L / h, after saturation adsorption, wash with deionized water until neutral, eluate with 30L 1% sodium chloride solution, collect the eluate and add it to a hollow cellulose membrane system with a molecular weight cut-off of 3000 for ultrafiltration , an appropriate amount of water was dialyzed, the permeate was added to the hollow cellulose membrane with a molecular weight cut-off of 100 for nanofiltration concentration, the concentrated solution was adjusted to pH 8, pressured and distilled with a distiller, the thin layer was detected until the distillation mother liquor was free of arecoline, the fractions were ...

Embodiment 3

[0028] The raw materials of betel nut, denucleated and pulverized, take 10kg, add pH2 hydrochloric acid solution and permeate for 24 hours, collect 150L percolation liquid, take 10L001 × 7 strong acid styrene-based cation exchange resin for treatment, pack the column, filter the percolation liquid and add Exchange adsorption, the flow rate is controlled at 6-8L / h, after saturation adsorption, wash with deionized water until neutral, eluate with 50L 2% sodium chloride solution, collect the eluate and add it to a tubular cellulose membrane system with a molecular weight cut-off of 3000. Filter, dialyze an appropriate amount of water, add the permeate to the tubular cellulose membrane with a molecular weight cut-off of 100 for nanofiltration concentration, adjust the pH of the concentrated solution to 8, pressurized distillation with a distiller, detect the thin layer until the distillation mother liquor is free of arecoline, collect the fractions, freeze After drying, 20.3 g of a...

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Abstract

The invention relates to a method for extracting arecoline from areca. The method comprises the following steps of: denucleating and crushing the areca serving as a raw material, percolating the crushed areca in aqueous solution of hydrochloric acid of which the amount is 15 to 25 times that of the crushed areca, collecting the percolate, adsorbing the percolate with a cation exchange resin column, eluting the cation exchange resin column with solution of sodium chloride of which the concentration is 1 to 4 percent and the volume is 4 to 6 times that of the column, performing ultrafiltration on the eluate in an ultrafiltration membrane system, concentrating the permeate with a nanofiltration membrane to obtain concentrated solution, adjusting the pH value of the concentrated solution to 7 to 8, distilling the concentrated solution under an increased pressure, collecting the fraction, and performing freeze dehydration on the fraction to obtain the product. The method is simply operated; a toxic reagent is not required in a preparation process; no pollution to environment is caused; the content of the product is high; and the method is suitable for industrial production.

Description

Technical field: [0001] The invention relates to a method for extracting arecoline from areca nut, in particular to a method for extracting and separating arecoline by adopting membrane separation and pressurized distillation. Background technique: [0002] Arecoline, colorless and odorless oily liquid, boiling point 209℃. Miscible with water, ethanol and ether, soluble in chloroform. It is easily destroyed under alkaline conditions, and can be volatilized with water vapor by distillation. [0003] Areca is an alkaloid extracted from Areca catecthu L., a palm plant. It has the functions of deworming, bactericidal, antithrombotic and anti-atherosclerosis. [0004] The extraction process of existing arecoline: [0005] Patent "The new technology of large-scale extraction and separation of arecoline", the disclosed method of this patent is to take the betel nut, pulverize it into coarse powder, put it in the percolation column after mixing with dilute hydrochloric acid, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D211/78
Inventor 李法庆杨成东刘东锋
Owner 苏州宝泽堂医药科技有限公司
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