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O-quaternary ammonium salt oligochitosan vanillina Schiff base bacteriostatic agent and preparation method thereof

A technology of polychitosan fragrance and oligochitosan, which is applied in the field of O-quaternary ammonium salt oligochitosan vanillin Schiff base antibacterial agent and its preparation, can solve the problem of no inhibitory activity and low antibacterial activity and other problems, to achieve the effect of improved antibacterial performance, simple operation, and safe operating environment

Inactive Publication Date: 2012-05-23
BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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Problems solved by technology

However, compared with the existing chemically synthesized antibacterial agents, the antibacterial activity is still low and basically has no inhibitory activity against fungi

Method used

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  • O-quaternary ammonium salt oligochitosan vanillina Schiff base bacteriostatic agent and preparation method thereof
  • O-quaternary ammonium salt oligochitosan vanillina Schiff base bacteriostatic agent and preparation method thereof
  • O-quaternary ammonium salt oligochitosan vanillina Schiff base bacteriostatic agent and preparation method thereof

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Experimental program
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Embodiment

[0032] 2.0g of chitosan oligosaccharides with a relative molecular weight of 5000 is dissolved in 2vt% acetic acid solution, and then an equal volume of methanol is added so that the concentration of chitosan oligosaccharides is 7wt%, and placed in a three-necked flask equipped with a stirrer Mix well and swell for 1h. Add aldehyde (-CHO / -NH 2 The molar ratio is 10:1), at this time the concentration of chitosan oligosaccharide is 3.5wt%, and the reaction is stirred and reacted at room temperature for 24h.

[0033] Take out the reaction solution, add dropwise 10wt% NaOH solution to adjust the pH value to be neutral, soak, stir and wash the retentate with 70wt% propanol solution or acetone with the same volume as the preparation solution for 3 to 4 times; Wash with ionized water until neutral. Finally soak overnight in methanol, filter and vacuum-dry at 40° C. to constant weight to obtain oligomeric chitosan Schiff base. According to the elemental analysis of the C / N ratio, t...

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Abstract

The invention discloses a natural bacteriostatic agent, i.e., an O-quaternary ammonium salt oligochitosan vanillina Schiff base and a preparation method thereof. The preparation method comprises the following steps of: modifying C2-NH2 on the molecular structure of oligochitosan with a strong bacteriostatic action on vanillina to synthesize an oligochitosan vanillina Schiff base; and grafting a quaternary ammonium salt into C6-OH in the structure of the oligochitosan vanillina Schiff base to synthesize the O-quaternary ammonium salt oligochitosan vanillina Schiff base. The preparation method is easy to operate, an operating environment is safe, and the antibacterial property and solubility of an obtained oligochitosan derivative are improved remarkably.

Description

technical field [0001] The invention belongs to a natural antibacterial agent, in particular to an O-quaternary ammonium salt oligomeric chitosan vanillin Schiff base antibacterial agent and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the concepts of health and green are more and more accepted by the public. The development of highly efficient, safe, broad-spectrum, and stable natural antiseptic antibacterial agents has attracted more and more attention from researchers. The market demand for natural antiseptic and antimicrobial agents is also bound to grow day by day. [0003] The research results at home and abroad show that the antibacterial activity of chitosan has a certain correlation with the molecular weight, and the oligomeric chitosan with a molecular weight of about 5000 has a significantly improved solubility and shows a strong antibacterial activity. However, compared with the existing chemical...

Claims

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Application Information

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IPC IPC(8): C08B37/08A01N43/16A01P1/00A01P3/00A61K31/722A61P31/04A61P31/10
CPCY02A50/30
Inventor 韩永萍林强张欢夏玥
Owner BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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