Core-shell nano particle for covering plant extractive and preparation method thereof

A plant extract, nanoparticle technology, applied in the preparation of microspheres, microcapsule preparations, etc., can solve problems such as insolubility, and achieve the effects of small particle diameter, delayed release, and easy water storage.

Inactive Publication Date: 2012-06-13
SHENZHEN HUACHUANG BIO PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor solubility of main components such as fatty acids and lactones in maca, kava, and ginger root oils, and the resulting bioavailability problems have become technical bottlenecks restricting their wide application.

Method used

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  • Core-shell nano particle for covering plant extractive and preparation method thereof
  • Core-shell nano particle for covering plant extractive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Step 1. Proportioning the following raw materials: 0.1mg Maca, 2mg PLA with a molecular weight of 100,000;

[0069] Step 2, dissolving the Maca and PLA in step 1 in 1ml acetocyanide to obtain acetocyanide solution A;

[0070] Step 3, 0.24mg soybean lecithin and 0.06mg DSPE-PEG-COOH were dissolved in 3ml 4% ethanol aqueous solution to obtain ethanol aqueous solution B;

[0071] Step 4. Under an ice bath, pipette the acetocyanide solution A obtained in step 2, and add it dropwise to the ethanol aqueous solution B obtained in step 3. Use probe-type ultrasonic ultrasound for 5 minutes of continuous ultrasonication, and use 10KDa ultrafiltration After the tube was ultrafiltered three times to remove organic solvents and free molecules, the polylactic acid-phospholipid-polyethylene glycol core-shell nanoparticles coated with Maca were obtained.

Embodiment 2

[0073] Step 1. Proportioning the following raw materials: 1mg Maca, 2mg PLA with a molecular weight of 100,000;

[0074] Step 2, dissolving the Maca and PLA in step 1 in 1ml acetocyanide to obtain acetocyanide solution A;

[0075] Step 3, 0.24mg soybean lecithin and 0.06mg DSPE-PEG-COOH were dissolved in 3ml 4% ethanol aqueous solution to obtain ethanol aqueous solution B;

[0076] Step 4. Under an ice bath, pipette the acetocyanide solution A obtained in step 2, and add it dropwise to the ethanol aqueous solution B obtained in step 3. Use probe-type ultrasonic ultrasound for 5 minutes of continuous ultrasonication, and use 10KDa ultrafiltration After the tube was ultrafiltered three times to remove organic solvents and free molecules, the polylactic acid-phospholipid-polyethylene glycol core-shell nanoparticles coated with Maca were obtained.

Embodiment 3

[0078] Step 1. Proportioning the following raw materials: 0.1mg Maca, 2mg PLA with a molecular weight of 100,000;

[0079] Step 2, dissolving the Maca and PLA in step 1 in 1ml acetocyanide to obtain acetocyanide solution A;

[0080] Step 3, 0.24mg soybean lecithin and 0.06mg DSPE-PEG-COOH were dissolved in 1.5ml 4% ethanol aqueous solution to obtain ethanol aqueous solution B;

[0081] Step 4. Under an ice bath, pipette the acetocyanide solution A obtained in step 2, and add it dropwise to the ethanol aqueous solution B obtained in step 3. Use probe-type ultrasonic ultrasound for 5 minutes of continuous ultrasonication, and use 10KDa ultrafiltration After the tube was ultrafiltered three times to remove organic solvents and free molecules, the polylactic acid-phospholipid-polyethylene glycol core-shell nanoparticles coated with Maca were obtained.

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Abstract

The invention discloses a core-shell nano particle for covering a plant extractive. The core-shell nano particle comprises a core substance which is the plant extractive; a core membrane is formed by polylactic acid; the polylactic acid covers the plant extractive to be used as an inner core of the core-shell nano particle; single layer of soya bean lecithin is wound around the surface of the polylactic acid and distearoyl phosphatidyl ethanolamine-carboxyl polyethylene glycol is inserted into the soya bean lecithin to be commonly used as a shell of the nano particle. A preparation method is characterized by comprising the following steps of: taking the polylactic acid with a better biocompatibility to be as a carrier; taking the soya bean lecithin and the distearoyl phosphatidyl ethanolamine-carboxyl polyethylene glycol as emulsifiers; and utilizing a one-step ultrasonic synthesizing method to prepare polylactic acid-phospholipid-polyethylene glycol core-shell nano particles for covering the plant extractive.

Description

technical field [0001] The invention belongs to the field of nanomedicine, and in particular relates to a core-shell nanoparticle wrapped with a plant extract and a preparation method thereof. Background technique [0002] Plant extract is a new type of high-tech product integrated with modern pharmaceutical technology, and it is also a new product form in the international natural medicine and health care product market. Its processing degree and technological content are relatively high. [0003] The plant extracts maca, kava, and ginger root oils are insoluble in water oils obtained by extracting the plant physiologically active components from maca root, kava root, and ginger root respectively. Among them, maca has the functions of anti-fatigue, strengthening physical strength, full energy, eliminating anxiety, regulating endocrine system and improving sexual function. Kava is a good antidepressant, with sedative hypnotic, antifungal, emotional stability, relieve depres...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 刘东
Owner SHENZHEN HUACHUANG BIO PHARM TECH CO LTD
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