Preparation method of Ainsliaea lactone substances

A technology of rabies and esters, which is applied in the field of preparation of rabies lactones, can solve the problems of long heating time of effective active ingredients, unstable ingredients, long time consumption, etc., and achieves easy control of operating parameters and extraction time Fast, low temperature effect

Inactive Publication Date: 2012-06-20
NANJING ZELANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing methods for extracting rabinolides mostly use alcohol extraction, organic solvent extraction, silica gel column chromatography and other methods, which have defects such as high temperature, long heating time of effective active ingredients, unstable components, long time-consuming, high cost, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take the medicinal material of the genus Tuerfeng long handle Tuerfeng and crush it. Under the conditions of pressure 20MPa and temperature 45°C, 80% methanol is introduced as an entrainer to participate in the extraction for 180min. The temperature of the desorption kettle is set at 12°C and the pressure is 18MPa. , add an appropriate amount of ethanol to disperse, oscillate evenly, add 3% activated carbon to reflux for decolorization, extract the decolorization solution twice with 2 times the amount of ether, combine the ether extracts, dehydrate with anhydrous sodium sulfate, concentrate under reduced pressure, and dry to obtain argolide Substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.

Embodiment 2

[0015] Take the thin-leaved rabbit-leaf genus Tuerfeng and pulverize it. Under the conditions of pressure 40MPa and temperature 30°C, inject 80% ethanol as an entrainer to participate in the extraction for 90min. Set the temperature of the desorption kettle to 25°C and the pressure to 6MPa, and collect the analyte. , add an appropriate amount of ethanol to disperse, oscillate evenly, add 1% activated carbon to reflux for decolorization, extract the decolorization solution with an equal amount of ether for 4 times, combine the ether extracts, dehydrate with anhydrous sodium sulfate, concentrate under reduced pressure, and dry to obtain rabies. Substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.

Embodiment 3

[0017] Take Tuerfeng medicinal material Biandi Tuerfeng and grind it. Under the conditions of pressure 30MPa and temperature 40℃, 80% isopropanol was introduced as an entrainer to participate in the extraction for 100min. The analytical solution was dispersed by adding an appropriate amount of ethanol, oscillated evenly, and then refluxed with 2% activated carbon for decolorization. The decolorized solution was extracted three times with 1.5 times the amount of ether, and the ether extracts were combined, dehydrated with anhydrous sodium sulfate, concentrated under reduced pressure, and dried to obtain Tuerfeng Lactone substances, of which the total content of umbelliferone, terpene, ainsliadimer A, and gochnatiolide A reaches more than 60%.

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PUM

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Abstract

The invention discloses a preparation method of Ainsliaea lactone substances. The lactone substances mainly comprise umbelliferone, Ainsliaea terpene, ainsliadimer A, gochatiolide A and the like. The invention particularly discloses the method for obtaining the Ainsliaea lactone substances by separating from Ainsliaea plants. The method comprises the following steps of raw material grinding, supercritical extraction, activated carbon decolorization, solvent extraction, dehydration, drying and the like so that the Ainsliaea lactone substances are finally obtained, wherein the total content of the umbelliferone, the Ainsliaea terpene, the ainsliadimer A and the gochatiolide A reaches above 60%.

Description

technical field [0001] The invention belongs to the technical field of extraction of plant effective components, and relates to a preparation method of rabinolides. Background technique [0002] Rabbit ( Ainsliaea DC), Compositae, about 70 species, distributed in eastern Asia, 45 species in my country, produced in Southwest, South and East China. Tu'erfeng is a folk medicine, also known as rabbit's ear wind. The plants of the genus Tuerfeng were first recorded in Zhao Xuemin's "Compendium of Materia Medica Daily Supplements" in the Qing Dynasty. There are many medicinal species of plants in this genus, and they are widely used to treat colds, coughs and asthma, rheumatic arthralgia, bruises, and urinary system diseases. "Shanghai Standards of Medicinal Materials", "Standards of Traditional Chinese Medicinal Materials in Jiangxi Province", "Drug Standards of Yunnan Province", and "Drug Standards of the Ministry of Health" are all recorded. [0003] According to the litera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P9/04A61P35/00A61P33/00A61P29/00
Inventor 刘东锋吴艳波
Owner NANJING ZELANG MEDICAL TECH
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