Manidipine hydrochloride solid dispersion, preparation and preparation method of above
A technology of manidipine hydrochloride and solid dispersion, which is applied in the field of manidipine hydrochloride solid dispersion and preparation and its preparation, can solve the problems of long duration of action, achieve high dissolution rate, facilitate storage and high bioavailability Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0032] Example one
[0033] A solid dispersion of manidipine hydrochloride is composed of manidipine hydrochloride and a dispersion medium PEG6000. The weight ratio of manidipine hydrochloride to PEG6000 is 10:90, and the average molecular weight of PEG6000 is 5500-7000.
[0034] The preparation method of manidipine hydrochloride solid dispersion: PEG6000 is heated to 60~80℃ to become liquid, add manidipine hydrochloride under constant stirring, stir and disperse for 30 minutes, quickly pour it on the metal panel into a thin layer of solid, and place it immediately Quench it at -20°C for 1 hour, take it out and smash it through a 100-mesh sieve to obtain a solid dispersion of manidipine hydrochloride.
Example Embodiment
[0035] Example two
[0036] A solid dispersion of manidipine hydrochloride is composed of manidipine hydrochloride and a dispersion medium PEG6000. The weight ratio of manidipine hydrochloride to PEG6000 is 25:75, and the average molecular weight of PEG6000 is 5500-7000.
[0037] The preparation method of manidipine hydrochloride solid dispersion: PEG6000 is heated to 60~80℃ to form a liquid, add manidipine hydrochloride under constant stirring, stir and disperse for 50 minutes, quickly pour it on the metal panel into a thin layer of solid, and place it immediately Quench at -30°C for 0.5 hour, take out and pulverize and pass through an 80-mesh sieve, to obtain a solid dispersion of manidipine hydrochloride.
Example Embodiment
[0038] Example three
[0039] A solid dispersion of manidipine hydrochloride is composed of manidipine hydrochloride and a dispersion medium PEG6000. The weight ratio of manidipine hydrochloride to PEG6000 is 40:60, and the average molecular weight of PEG6000 is 5500-7000.
[0040] The preparation method of manidipine hydrochloride solid dispersion: PEG6000 is heated to 60~80℃ to form a liquid, add manidipine hydrochloride under constant stirring, stir and disperse for 20 minutes, quickly pour it on the metal panel into a thin layer of solid, and place it immediately Quench at -20°C for 2 hours, take out and pulverize and pass through a 100-mesh sieve to obtain a solid dispersion of manidipine hydrochloride.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap