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Thermoplastic degradable fiber woven stent and preparation method thereof

A technology of degrading fibers and thermoplastics, applied in stents, medical science, surgery, etc., can solve problems such as insufficient radial support force, and achieve the effects of preventing stenosis or blockage, facilitating adhesion, and relieving irritation

Inactive Publication Date: 2012-07-18
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current stents made of degradable polymer materials encounter the problem of insufficient radial support force

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Cross-braid lactide and glycolide copolyester fibers with a diameter of 0.2mm into a tubular object with an inner diameter of 6mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 6mm, and place the After being placed in an oven at 80°C for 5 minutes, the fibers are bonded to each other at the crossing points, and then cooled and removed to obtain a tube without loose fibers.

[0044] Coat the chitosan-acetic acid-water solution on the above-mentioned tubular body surface through heat treatment, the mass concentration of chitosan in the chitosan-acetic acid-water solution is 2%, the mass ratio of acetic acid and water is 3: 100, coating amount is every centimeter of tubular body 0.023 g, then place the tube coated with chitosan-acetic acid-water solution in 20°C absolute ethanol, shake it for 10 minutes, take it out; put it in fresh 20°C absolute alcohol, shake it for 10 minutes, take it out Elution of acetic acid; drying in...

Embodiment 2

[0046] Cross-braid polydioxanone fibers with a diameter of 0.3mm into a tubular object with an inner diameter of 6mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 6mm, and place it at 110°C After 10 minutes in the oven, use a mold with an inner diameter of 6.5mm to press together. The fibers are bonded to each other at the intersection point, and then cooled and removed to obtain a tubular shape in which the fibers do not become loose.

[0047]Coat chitosan acetic acid-water solution on the surface of the above-mentioned tubes that have been hot-pressed, the mass concentration of chitosan in chitosan-acetic acid-water solution is 2%, the mass ratio of acetic acid to water is 3:100, and the coating amount is per centimeter 0.035 g of the tube, and then place the tube coated with chitosan acetic acid-water solution in 20°C absolute ethanol, take it out after shaking for 5 minutes; put it in fresh 20°C absolute alcohol, shake it fo...

Embodiment 3

[0049] Cross-braid polylactide fibers with a diameter of 0.6mm into a tubular object with an inner diameter of 8mm and a mesh structure, and then put this tubular object on a metal rod with an outer diameter of 8mm, and place it in an oven at 80°C for 15 minutes. , the fibers are bonded to each other at the intersection points, and then cooled and removed to obtain a tubular scaffold in which the fibers do not loosen. This stent has a radial support force of 335 centinewtons per cm.

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Abstract

The invention discloses a thermoplastic degradable fiber woven stent having a chitosan coating. The thermoplastic degradable fiber woven stent is prepared by the following steps: weaving degradable fiber into a tubular object with a net structure; bonding fibers in the tubular object at intersecting points via a thermal treatment or thermal press-bonding method, to prevent fiber looseness and endow the stent with high radial supporting force; coating the tubular object with a chitosan-acetic acid-water solution, and placing in anhydrous ethanol to form a chitosan coating; and removing ethanol in a vacuum drying oven. The obtained stent is high in radial supporting force, and can be completely degraded in vivo.

Description

technical field [0001] The invention relates to a thermoplastic degradable fiber braided bracket and a preparation method thereof, in particular to a thermoplastic degradable fiber braided bracket used for supporting internal pipelines of a human body and preventing narrowing or blockage of human internal pipelines and a preparation method thereof. Background technique [0002] Due to various reasons, the internal pipes of the human body can become narrowed or blocked, and metal stents are currently used to prevent and treat such diseases. However, the metal stent is difficult to remove, which brings some side effects. Fabricating stents with degradable polymer materials is one of the ways to solve the side effects of metal stents. However, the current stents made of degradable polymer materials encounter the problem of insufficient radial support force. Improving the radial support force of degradable polymer scaffolds is a key to make degradable polymer scaffolds have pr...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L31/14A61L31/06A61L31/10
Inventor 赵炯心陈南梁张秀芳张幼维戴明欣李文刚
Owner DONGHUA UNIV
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