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Method for improving usability of biomedical degradable magnesium alloy cardiovascular stent

A biomedical and magnesium alloy technology, applied in medical science, surgery, etc., can solve the problems of large expansion and rebound of stents, excessive local stress, and large residual stress, so as to reduce expansion rebound, reduce residual stress, and reduce The effect of stress corrosion rate

Active Publication Date: 2013-10-02
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it solves the problems of excessive local stress, large residual stress, and large springback of the expansion of the magnesium alloy stent.

Method used

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  • Method for improving usability of biomedical degradable magnesium alloy cardiovascular stent
  • Method for improving usability of biomedical degradable magnesium alloy cardiovascular stent
  • Method for improving usability of biomedical degradable magnesium alloy cardiovascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Bracket models such as figure 1 As shown, the stent crimping expansion model is as follows figure 2 As shown, the scaffold material used is the extruded AZ31 wrought magnesium alloy, and the mechanical properties of the material are shown in Table 1.

[0033] Table 1 Main mechanical property parameters of AZ31 wrought magnesium alloy in extruded state

[0034]

[0035] First, press the stent with an outer diameter of 2.4 mm and an inner diameter of 2.12 mm to an inner diameter of 1.1 mm, remove the stent, and anneal the stent in a vacuum or an inert protective atmosphere at a temperature of 250-400°C for 1-4 hours (this In the embodiment, the temperature is 300°C and the time is 4h); after the annealing treatment (stent surface treatment or drug-loaded coating can be applied at this time), the stent continues to be crimped to an inner diameter of 1.0mm (pre-crowned inner diameter), After removing the gripping force, expand the stent to an inner diameter of 3.0 mm ...

Embodiment 2

[0041] In this example, an extruded AZ31 degradable magnesium alloy stent was produced by laser cutting method. The diameter of the stent is 2.4mm, the wall thickness is 0.14mm, the width of the column and beam of the stent gradually transitions from 0.14mm to 0.10mm, the length of the ring of the stent unit is 1.3mm, and the connecting rib The length is 0.3mm, the total length of the stent is 4.5mm, and the stent passes through the electrodissection light.

[0042] Firstly, the stent is crimped to an inner diameter of 1.1mm by a stent crimping machine, the stent is taken out, annealed at 350°C for 3 hours, and the surface of the stent is treated. It is tightly attached to the balloon, and then inflated by the balloon, and the inner diameter of the expanded diameter reaches 3.0mm, and the stent mesh is complete without broken wires. Continue to expand the inner diameter of the stent to 3.18mm before the stent mesh breaks.

[0043] Then, take another stent and expand it to an ...

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Abstract

The invention belongs to the technical field of biological materials and in particular provides a method for improving usability of a biomedical degradable magnesium alloy cardiovascular stent. The method is characterized by comprising the following steps of: firstly pre-press-holding the magnesium alloy cardiovascular stent until the diameter is 1.05-1.25 times the finally press-holding diameter, then carrying out full annealing treatment on the stent, treating the surface of the stent or coating a drug-loading coating after annealing treatment, then continuing press-holding the stent till the preset dimension so that the stent is closely attached to a sacculus and carrying out subsequent packaging and sterilizing. The method has the beneficial effects that the maximum stress of the press-holding expansion process, the residual stress of the stent after press-holding expansion and expansion resilience can be reduced by introducing the annealing process; the stress safety of the stent and the implantation success rate can be improved by reducing the maximum stress; by reducing the residual stress, the stress corrosion tendency and degradation rate of the stent are reduced and the supporting time of the stent is prolonged; and by reducing expansion resilience, the attachment properties of the stent and blood vessels are improved and the probability of vascular restenosis caused by stent implantation is reduced.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, is particularly suitable for the field of using methods of magnesium alloy stents, and specifically relates to a method for improving the performance of biomedical degradable magnesium alloy cardiovascular stents. Background technique [0002] With the improvement of people's material living standards and changes in lifestyle, the incidence of cardiovascular disease is getting higher and higher, and it has been recognized as the "first killer" of human beings. Trauma and high efficiency, the curative effect and significance in the treatment of cardiovascular diseases are particularly prominent. Vascular stent implantation has become the most effective and commonly used medical method for the treatment of cardiovascular diseases. Vascular stent is a hollow tube made of metal or polymer microtubes by laser cutting or other processing methods to form a mesh structure. During the operation, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22F1/06A61L31/02A61L31/16
Inventor 李军雷谭丽丽郑丰杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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