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Application of anwuweizic acid in preparation of medicine for preventing and treating hepatitis virus
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A technology of hepatitis virus and hepatitis B virus, applied in the field of compounds, to achieve the effect of significant anti-HBV and anti-HCV activity
Inactive Publication Date: 2012-07-18
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Effect test
Embodiment 1
[0016] Example 1 Antic acid anti-hepatitis B virus test
[0017] 1. Experimental drugs, reagents and materials
[0023] 6. Cell line HepG 2.2.15, which is the 2.2.15 cell line transfected with HBV-DNA clones into human livercancer cells.
[0024] 2. Experimental method: operate according to the instructions of the kit
[0025] Take HepG 2.2.15 cells in the logarithmic growth phase and adjust the cell concentration to 2×10 5 1 / ml, take 100 μl of a 96-well plate; the drug was diluted and cultured for 24 h...
Embodiment 2
[0042] Example 2 Antic acid anti-hepatitis C virus test
[0043] 1. Experimental drugs, reagents and materials
[0044] 1. Compound: Anpentacic acid.
[0045] 2. Cell line Huh7, human livercancercell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY, 2011; 85( 6): 2793–2802; Jin Zhong, Pablo Gastaminza, Guofeng Cheng, et al. Robust hepatitis C virus infection in vitro, PNAS, 2005; 102(26):9294-9299).
[0046] 3. Cell line 293T, human embryonic kidney cell line (see: Yimin Tong, Yongzhe Zhu, Xueshan Xia, Yuan Liu, et al. Tupaia CD81, SR-BI, Claudin-1, and Occludin Support Hepatitis C Virus Infection, JOURNAL OF VIROLOGY. 2011; 85( 6): 2793–2802 ; Graham, F. L., Smiley, J., Russell, W. C. & Nairn, R. J. Gen. Virol 1977;36:59–74).
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Abstract
The invention provides an application of anwuweizic acid in preparation of a medicine for preventing and treating hepatitisvirus, wherein anwuweizic acid is a tetracyclic triterpenoid compound. The invention also provides an application of anwuweizic acid in preparation of food and health care products for protecting liver. According to the invention, the application of the tetracyclic triterpenoid compound namely anwuweizic acid in preparing the medicine for resisting hepatitis B virus (HBV) and hepatitis C virus (HCV) is provided; and the test result proves that the tetracyclic triterpenoid compound has remarkable activity in the aspect of resisting HBV and HCV, and is especially capable of inhibiting HCV to invade target cells, thus being used for preparing the medicine for resisting HBV and HCV. The invention provides a new source for finding out the medicine for resisting HBV and HCV.
Description
technical field [0001] The invention relates to the application of a compound, in particular, the application of anpentacic acid in the preparation of drugs for preventing and treating hepatitis viruses. Background technique [0002] The chemical structure of anpentateic acid is as follows: [0003] . [0004] Anwuweizic acid (anwuweizic acid) is derived from SchisandraSchisandraSchisandra sphenanthera Rehd.et. ) Tetracyclic triterpenoids isolated from the fruit (for details, see: Liu Jiasen, Huang Meifen. Studies on Schisandra chinensis (Ⅳ)—Structures of anpentacic acid and dl-anpentesin and d-table Bassin's absolute configuration [ J ]. Acta Chemical Sinica, 1984, 42 (3): 264), it was reported that anpentacic acid had a significant inhibitory effect on human decidual cells and rat luteal cells (for details, see: Chen Yegao, Lin Zhongwen, Cao Lin, etc. Narrow Yenan Antifertility activity triterpene acid in Schisandra chinensis, Chinese Modern Applied Pharmacy, 2002;...
Claims
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Application Information
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IPC IPC(8): A61K31/575A61P31/20A61P31/14A23L1/30
Inventor 陈海生戚中田金永生朱勇喆杜景伶赵平钱汐晶
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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