Application of anwuweizic acid in preparation of medicine for preventing and treating hepatitis virus

Abstract

The invention provides an application of anwuweizic acid in preparation of a medicine for preventing and treating hepatitis virus, wherein anwuweizic acid is a tetracyclic triterpenoid compound. The invention also provides an application of anwuweizic acid in preparation of food and health care products for protecting liver. According to the invention, the application of the tetracyclic triterpenoid compound namely anwuweizic acid in preparing the medicine for resisting hepatitis B virus (HBV) and hepatitis C virus (HCV) is provided; and the test result proves that the tetracyclic triterpenoid compound has remarkable activity in the aspect of resisting HBV and HCV, and is especially capable of inhibiting HCV to invade target cells, thus being used for preparing the medicine for resisting HBV and HCV. The invention provides a new source for finding out the medicine for resisting HBV and HCV.

Description

technical field

[0001] The invention relates to the application of a compound, in particular, the application of anpentacic acid in the preparation of drugs for preventing and treating hepatitis viruses. Background technique

[0002] The chemical structure of anpentateic acid is as follows:

[0003] .

[0004] Anwuweizic acid (anwuweizic acid) is derived from Schisandra Schisandra Schisandra sphenanthera Rehd.et. ) Tetracyclic triterpenoids isolated from the fruit (for details, see: Liu Jiasen, Huang Meifen. Studies on Schisandra chinensis (Ⅳ)—Structures of anpentacic acid and dl-anpentesin and d-table Bassin's absolute configuration [ J ]. Acta Chemical Sinica, 1984, 42 (3): 264), it was reported that anpentacic acid had a significant inhibitory effect on human decidual cells and rat luteal cells (for details, see: Chen Yegao, Lin Zhongwen, Cao Lin, etc. Narrow Yenan Antifertility activity triterpene acid in Schisandra chinensis, Chinese Modern Applied Pharmacy, 2002;...