Intranasal insulin preparation and preparation method thereof
An insulin and preparation technology, applied in the field of non-injectable insulin, can solve problems such as failure to meet the requirements of clinical treatment of diabetes
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Embodiment 1
[0115] Human insulin was used to prepare experimental nasal insulin preparations.
[0116] Table 1. A group of nasal insulin preparations for animal experiments consisting of the following ingredients and concentrations in phosphate buffer.
[0117]
[0118] Table 2. Another group of nasal insulin preparations for animal experiments, which consists of the following ingredients and concentrations dissolved in phosphate buffer.
[0119]
[0120] Certain cell-penetrating peptides described in Table 1 and Table 2 are cell-penetrating peptides containing 16 amino acids:
[0121] Arg Trp Phe Lys Ile Gln Met Gln Ile Arg Arg Trp Lys Asn Lys Lys
[0122] A certain cell-penetrating peptide described in Table 1 and Table 2 can also be a cell-penetrating peptide containing 18 amino acids:
[0123] Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Gly Gly
[0124] The preparation method of above-mentioned insulin preparation, its steps are:
[0125] 1. Accurately we...
Embodiment 2
[0134] Preparation of Nasal Insulin Preparation for Experimental Use of Porcine Insulin
[0135] Table 3. A group of nasal insulin preparations for animal experiments, which consist of the following components and concentrations dissolved in medical sterile water.
[0136]
[0137] Table 4. Another group of nasal insulin preparations for animal experiments, which consists of the following ingredients and concentrations dissolved in medical sterile water.
[0138]
[0139] Certain cell-penetrating peptides described in Table 3 and Table 4 are cell-penetrating peptides containing 16 amino acids:
[0140] Arg Trp Phe Lys Ile Gln Met Gln Ile Arg Arg Trp Lys Asn Lys Lys
[0141] Certain cell-penetrating peptides described in Table 3 and Table 4 can also be cell-penetrating peptides containing 14 amino acids:
[0142] Arg Trp Phe Lys Ile Gln Gln Arg Arg Trp Lys Asn Lys Lys
[0143] The preparation method of the insulin preparation described above, its steps are the same as ...
Embodiment 3
[0145] Preparation of Experimental Nasal Insulin Preparations Using Insulin Analogs
[0146] Table 5. A group of nasal insulin preparations for animal experiments, consisting of the following components and concentrations dissolved in phosphate buffer.
[0147]
[0148] Table 6. Another group of nasal insulin preparations for animal experiments, which consists of the following ingredients and concentrations dissolved in medical sterile water.
[0149]
[0150] The insulin analog described in Table 5 and Table 6 is insulin aspart.
[0151] Certain cell-penetrating peptides described in Table 5 and Table 6 are cell-penetrating peptides containing 18 amino acids:
[0152] Arg Trp Phe Lys Ile Gln Met Gln Ile Arg Arg Trp Lys Asn Lys Lys Arg Arg
[0153] A certain cell-penetrating peptide described in Table 5 and Table 6 can also be a cell-penetrating peptide containing 14 amino acids:
[0154] Arg Gln Ile Lys Ile Trp GlnArg Arg Met Lys Trp Lys Lys
[0155] The preparation...
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