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Wormwood leaf extract and application thereof in preparation of anti-hepatitis B virus medicines

A kind of Artemisia argyi leaf extract, anti-hepatitis B technology, applied in antiviral agents, drug combinations, pharmaceutical formulas, etc., can solve the problems that have not yet been seen with Artemisia argyi leaf extract, achieve strong anti-hepatitis B virus activity, and simple extraction method

Active Publication Date: 2013-10-16
河南省医药科学研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report about the use of Artemisia argyi leaf extract for anti-hepatitis B virus

Method used

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  • Wormwood leaf extract and application thereof in preparation of anti-hepatitis B virus medicines
  • Wormwood leaf extract and application thereof in preparation of anti-hepatitis B virus medicines
  • Wormwood leaf extract and application thereof in preparation of anti-hepatitis B virus medicines

Examples

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Effect test

Embodiment 1

[0023] An extract of mugwort leaves, the active ingredients of which include compounds such as flavonoids, coumarins, lactones, phenols, organic acids, steroids and triterpenes. The Artemisia argyi extract is prepared by the following method: take 1 kg of crushed Artemisia argyi and place it in a flask, add 6000ml of ethyl acetate to shake and mix, soak for about 12 hours, then reflux the Artemisia argyi and the soaking solution for 2 hours (the flask can be put into several grains of zeolite), let it stand for about 15 minutes after the reflux, and then filter. Mix the filter residue with 4000ml ethyl acetate, reflux for 2 hours again, and filter; combine the filtrates obtained twice, then concentrate with a rotary evaporator, transfer to an evaporating dish when concentrated to a small amount, evaporate to dryness in a water bath, and vacuum dry at 60°C for 8 hours to obtain 21.5g Dark green extract.

Embodiment 2

[0025] An extract of mugwort leaves, the active ingredients of which include compounds such as flavonoids, coumarins, lactones, phenols, organic acids, steroids and triterpenes. The Artemisia argyi extract is prepared by the following method: take 1 kg of crushed Artemisia argyi and put it in a flask, add 9000ml of ethyl acetate to shake and mix, soak for about 24 hours, then reflux the Artemisia argyi leaves and the soaking solution for 4 hours, and let stand after the reflux A moment, then filter. The obtained filtrate was concentrated with a rotary evaporator, and when it was concentrated to a certain amount, it was transferred to an evaporating dish, evaporated to dryness in a water bath, and dried in vacuum at 60°C for 8 hours to obtain 20.0 g of dark green extract.

Embodiment 3

[0027] An extract of mugwort leaves, the active ingredients of which include compounds such as flavonoids, coumarins, lactones, phenols, organic acids, steroids and triterpenes. The Artemisia argyi extract is prepared by the following method: take 1 kg of pulverized Artemisia argyi leaves in a flask, add 5000ml of ethyl acetate to shake and mix, soak for about 10 hours, then reflux the Artemisia argyi leaves and the soaking solution for 3 hours, and let stand after the reflux A moment, then filter. Mix the filter residue with 5000ml of ethyl acetate, reflux again for 2h, and filter; combine the filtrate obtained twice, then concentrate with a rotary evaporator, transfer to an evaporating dish when concentrated to a small amount, evaporate to dryness in a water bath, and vacuum dry at 60°C for 8h to obtain 22.6g Dark green extract.

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PUM

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Abstract

The invention relates to a wormwood leaf extract which comprises effective components including flavone, coumarin, lactone, phenol, organic acid, steride and triterpene compounds. The wormwood leaf extract is prepared by adopting the following steps of: soaking wormwood leaves with ethyl acetate, refluxing, carrying out solid-liquid separation after refluxing is ended, concentrating the obtained liquid and drying to obtain the wormwood leaf extract. The wormwood leaf extract is simple in an extraction method; and proved by in vitro cell tests, the wormwood leaf extract has strong anti-hepatitis B virus and can be used for preparing the anti-hepatitis B virus medicines.

Description

technical field [0001] The invention belongs to the technical field of natural plant extraction and application, and in particular relates to an extract of mugwort leaves and its application in preparing anti-hepatitis B virus drugs. Background technique [0002] Hepatitis B is a worldwide disease caused by Hepatitis B Virus (HBv). According to statistics, there are currently about 2 billion people in the world who have been infected with HBV, of which about 350 million are HBV carriers, and there are about 120 million HBV carriers in my country. Hepatitis B virus is the main cause of acute and chronic hepatitis, liver cirrhosis, and liver cancer. Every year, 300,000 to 500,000 people die from liver cirrhosis or liver cancer caused by HBV. Currently clinical anti-HBV drugs are mainly interferon and nucleoside drugs. Although these two types of drugs have achieved relatively good curative effects in the treatment of HBV infection, it has been reported that the range of indi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/282A61P31/20A61P1/16A61K127/00
Inventor 赵志鸿郑立运张壮丽张小俊王桂芳张长征张艳马方王宁侯迎迎黄勇勇陈慧平邹敏王庆端
Owner 河南省医药科学研究院
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