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Hydrogel contact lens material and preparation method thereof

A contact lens, hydrogel technology, applied in glasses/goggles, instruments, optics, etc., can solve problems such as tear elution, and achieve the effects of good stability, high water content, and excellent anti-dehydration performance

Inactive Publication Date: 2012-08-01
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding water-soluble polymers such as PVP or PVA to the product can improve the anti-dehydration performance of contact lenses to a certain extent, but the added polymers are easily eluted by tears

Method used

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  • Hydrogel contact lens material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] Embodiment 1 (comparative example)

[0030]2 g of β-hydroxyethyl methacrylate (HEMA), 0.01 g of ethylene glycol dimethacrylate (EGDMA), 0.01 g of initiator alkyl aryl ketone Darocur-1173, magnetic stirring, mix well, pour into the mold Among them, it is cured by ultraviolet light, demolded, soaked in water and washed, and placed in saline to obtain a hydrogel contact lens. The material is optically transparent, with a water content of 36%, a Young's modulus of 1.4 MPa, a water contact angle of 65 degrees, and a relative dehydration percentage (RPD5) of 40% at 5 minutes.

Embodiment 2

[0032] 1.9 g of β-hydroxyethyl methacrylate (HEMA) and 0.1 g of N-(1,3-dihydroxy-2-propyl)methacrylamide, 0.01 g of ethylene glycol dimethacrylate (EGDMA) , 0.01 g initiator Darocur-1173, magnetically stirred, mixed evenly, poured into the mold, cured with ultraviolet light, demolded, soaked in water and washed, placed in saline to obtain hydrogel contact lenses. The material is optically transparent, with a water content of 42%, a Young's modulus of 1.2 MPa, a water contact angle of 55 degrees, and a relative dehydration percentage (RPD5) of 33% at the 5th minute.

Embodiment 3

[0034] 1.8 g of β-hydroxyethyl methacrylate (HEMA) and 0.2 g of N-(1,3-dihydroxy-2-propyl)methacrylamide, 0.01 g of ethylene glycol dimethacrylate (EGDMA) , 0.01 g initiator Darocur-1173, magnetically stirred, mixed evenly, injected into the mold, cured with ultraviolet light, demolded, soaked in water and washed, placed in saline to obtain hydrogel contact lenses, water content: 45% , Young's modulus: 1.2 MPa, water contact angle 50 degrees, RPD5 is 30%.

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Abstract

The invention provides a hydrogel contact lens material and a preparation method thereof. The material comprises N-(1,3-dihydroxy-2-propyl) methyl acrylamide, acrylate monomer, acrylate crosslinker and initiating agent and is prepared through one-step ultraviolet-initiated or thermal-initiated polymerization. The preparation method comprises the steps as follows: the N-(1,3-dihydroxy-2-propyl) methyl acrylamide and acrylic acid or acrylamide monomer are uniformly mixed with the acrylate crosslinker and the initiating agent, or the N-(1,3-dihydroxy-2-propyl) methyl acrylamide and the acrylic acid or acrylamide monomer are uniformly mixed with the acrylate crosslinker, the initiating agent and diluent; then the mixture is poured into a mould to be subjected to one-step ultraviolet irradiation curing or heat curing in a baking oven; and the mould is opened and immersed in water or alcohol, so as to remove the diluent and unreacted monomer to obtain a hydrogel contact lens. The material has high water content and excellent water retention capacity.

Description

technical field [0001] The invention relates to a soft corneal contact lens hydrogel material and a preparation method thereof, belonging to the technical field of biomedical materials. Background technique [0002] β-Hydroxyethyl methacrylate (HEMA) cross-linked polymer is the earliest soft contact lens material, which is simply cured by HEMA monomer and a small amount of cross-linking agent. It has good mechanical properties, optical properties and biocompatibility. However, this material has a low water content, about 38%, and is prone to protein deposition during wearing. Oxygen permeability is also poor. When worn, oxygen cannot fully pass through the lens material to reach the eyes. Long-term wear will cause insufficient oxygen supply to the eyes, causing eye redness, swelling and discomfort and other related eye diseases. In order to improve the oxygen permeability of the material, the researchers introduced highly hydrophilic components into the PHEMA gel material ...

Claims

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Application Information

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IPC IPC(8): C08F220/28C08F220/58C08F222/14C08F230/08C08F220/54C08F290/06C08F2/48G02B1/04G02C7/04
Inventor 李新松郭亮
Owner SOUTHEAST UNIV
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