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Method for preparing high-purity matrine from sophora alopecuroides

A technology for matrine and Sophora fragrans, which is applied in the field of preparing high-purity matrine, can solve the problems of not producing an ideal effect, the separation technology is not ideal, mature, and the content of matrine is not increased, and achieves strong industrial practicability. , to avoid partial loss, the effect of increasing yield

Inactive Publication Date: 2012-08-15
NINGXIA BAUHINIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, domestic and foreign medical circles have paid more attention to the research on the extraction and separation of Sophora sophorae, and have continuously improved on the basis of traditional extraction and separation methods, and have done a lot of experimental research, but the extraction and separation technology in actual production has not reached ideal and mature. However, the application did not produce the desired effect, nor did it increase the content of matrine

Method used

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  • Method for preparing high-purity matrine from sophora alopecuroides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Put the bitter beans into the extraction tank, add water to pass through the steam, heat and extract, settle and filter;

[0028] (2) Concentrate the extract;

[0029] (3) Add caustic soda and sodium hydroxide to the concentrated solution to adjust the pH to 11-12, repeat the extraction several times with toluene, neutralize the extract with 10% hydrochloric acid to make the pH 4-5, and separate the neutralized liquid on the tower;

[0030] (4) Separate matrine neutralizing solution, add liquid caustic soda sodium hydroxide to adjust pH to 7-8, add aluminum-nickel alloy catalyst, pass hydrogen, heat until there is no sophocarpine and sophoramine in the neutralizing solution. Add liquid alkali and sodium hydroxide to the hydrogenation solution to adjust the pH to 11-12, let it stand still, and centrifuge to obtain a crude product of matrine;

[0031] (5) Add 5% HCL to the crude product of matrine to adjust the pH value to 5-6, let it sit for 2 hours and filter it in...

Embodiment 2

[0034] (1) Put the bitter beans into the extraction tank, add water to pass through the steam, heat and extract, settle and filter;

[0035] (2) Concentrate the extract;

[0036] (3) Add caustic soda and sodium hydroxide to the concentrated solution to adjust the pH to 11-12, repeat the extraction several times with toluene, neutralize the extract with 10% hydrochloric acid to make the pH 4-5, and separate the neutralized liquid on the tower;

[0037] (4) Separate matrine neutralizing solution, add liquid caustic soda sodium hydroxide to adjust pH to 7-8, add aluminum-nickel alloy catalyst, pass hydrogen, heat until there is no sophocarpine and sophoramine in the neutralizing solution. Add liquid alkali and sodium hydroxide to the hydrogenation solution to adjust the pH to 11-12, let it stand still, and centrifuge to obtain a crude product of matrine;

[0038] (5) Add distilled water to the primary crude product, then heat to dissolve, cool, and centrifugally dry to obtain th...

Embodiment 3

[0041] (1) Put the bitter beans into the extraction tank, add water to pass through the steam, heat and extract, settle and filter;

[0042] (2) Concentrate the extract;

[0043] (3) Add potassium hydroxide to the concentrated liquid to adjust the pH to 11-12, repeat the extraction with toluene several times, neutralize the extract with 10% hydrochloric acid to make the pH 4-5, and separate the neutralized liquid on the tower;

[0044] (4) Separate matrine neutralizing solution, add liquid caustic soda potassium hydroxide to adjust pH to 7-8, add aluminum-nickel alloy catalyst, pass hydrogen, heat until there is no sophocarpine and sophoramine in the neutralizing solution. Add liquid alkali potassium hydroxide to the hydrogenation solution to adjust the pH to 11-12, let it stand still, and centrifuge to obtain a crude product of matrine;

[0045] (5) Add 5% HCL to the crude product of matrine to adjust the pH value to 5-6, let it sit for 2 hours and filter it into the free cr...

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Abstract

The invention provides a method for preparing high-purity matrine from sophora alopecuroides. Compared the method with other technologies at home and abroad, a process technology is improved further, the sequence of alkaloid extraction and hydrogen reaction is adjusted, and a separation scheme of dissolving by adding water firstly and then heating is adopted in a recrystalization process, so that the yield is improved obviously, the quality is improved, and a fussy technological process is avoided to enable the technological process to be better simplified; and the cost is reduced, the industrial applicability is strong, and thus the method is applicable to mass production.

Description

technical field [0001] The invention relates to a method for preparing high-purity matrine from Sophora sophora. Background technique [0002] Sophora alopecuroides and Sophora sophora are plants of the genus Sophora in the family Fabaceae, which are extremely bitter in taste, cold in nature and poisonous. It is mainly distributed in the desert and semi-desert areas of northern China in relatively humid areas. It is an important medicinal plant resource and a component of natural vegetation in Ningxia, and is listed as one of the six authentic medicinal materials under key protection. Bitter bean has the functions of clearing away heat and detoxification, antibacterial and anti-inflammatory, relieving pain and killing insects. Its main chemical components include proteins, sugars, organic acids, flavonoids, pigments and various alkaloids, and the content of matrine in the alkaloids is the highest, and one of the main sources of matrine is the bitter bean. Modern pharmacolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/22
Inventor 白锋云张勇汪晓东陈殿河
Owner NINGXIA BAUHINIA PHARMA
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