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Preparation method for water-soluble Ag2S quantum dot

A quantum dot, water-soluble technology, applied in the field of chemistry and material science, can solve the problems of harsh reaction conditions, cytotoxicity, expensive raw materials, etc., and achieve the effect of simple preparation conditions, high reproducibility, and good monodispersity

Inactive Publication Date: 2012-08-22
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are some shortcomings in the existing preparation technology: (1), the fluorescence emission wavelength of traditional quantum dots (such as CdSe, CdS) is in the visible light range, so it is difficult to avoid the interference of biological autofluorescence when used in biological systems , and it is difficult to mark deep tissues; (2), the Cd element contained in traditional quantum dots has cytotoxicity, which restricts its development in the field of biomedicine; (3), most of the existing quantum dot preparation technologies obtain Quantum dots can only be dissolved in organic solvents, not in aqueous systems, so they cannot be directly applied to biological systems. (4) The raw materials required by the existing quantum dot preparation technology are expensive, some of which are highly toxic, and Reaction conditions are harsh (e.g. high temperature)

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  • Preparation method for water-soluble Ag2S quantum dot
  • Preparation method for water-soluble Ag2S quantum dot
  • Preparation method for water-soluble Ag2S quantum dot

Examples

Experimental program
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Effect test

Embodiment 1

[0025] ① Add 10ml of ethylene glycol into the three-necked flask, and pass Ar gas under the liquid surface for 30 minutes to remove the air; then change to the liquid surface to ventilate until the whole reaction is over;

[0026] ②In an Ar atmosphere, heat up the ethylene glycol liquid, and add 0.05mmol of silver nitrate and 100μl of mercaptopropionic acid at 110°C;

[0027] ③After the reactants are mixed evenly, heat up to 145°C;

[0028] ④ Start timing after reaching 145°C, and the reaction time is 5 minutes;

[0029] ⑤After the reaction is completed, add the reaction solution to cold water to cool down rapidly, precipitate the product by centrifugation, discard the supernatant, and collect the bottom precipitate, which is the obtained quantum dot product;

[0030] ⑥ Dissolve the precipitate in alkaline aqueous solution to obtain Ag with a fluorescence emission wavelength of 630 nm 2 S quantum dot solution.

Embodiment 2

[0032] ① Add 10ml of ethylene glycol into the three-necked flask, and pass Ar gas under the liquid surface for 30 minutes to remove the air; then change to the liquid surface to ventilate until the whole reaction is over;

[0033] ②In an Ar atmosphere, heat up the ethylene glycol liquid, and add 0.05mmol of silver nitrate and 100μl of mercaptopropionic acid at 110°C;

[0034] ③After the reactants are mixed evenly, heat up to 145°C;

[0035] ④ Start timing after reaching 145°C, and the reaction time is 15 minutes;

[0036] ⑤After the reaction is completed, add the reaction solution to cold water to cool down rapidly, precipitate the product by centrifugation, discard the supernatant, and collect the bottom precipitate, which is the obtained quantum dot product;

[0037] ⑥Dissolve the precipitate in alkaline aqueous solution to obtain Ag with a fluorescence emission wavelength of 910 nm 2 S quantum dot solution.

Embodiment 3

[0039] ① Add 10ml of ethylene glycol into the three-necked flask, and pass Ar gas under the liquid surface for 30 minutes to remove the air; then change to the liquid surface to ventilate until the whole reaction is over;

[0040] ②In an Ar atmosphere, heat up the ethylene glycol liquid, and add 0.05mmol of silver nitrate and 100μl of mercaptopropionic acid at 110°C;

[0041] ③After the reactants are mixed evenly, heat up to 145°C;

[0042] ④ Start timing after reaching 145°C, and the reaction time is 30 minutes;

[0043] ⑤ After the reaction is completed, cool the reaction solution to room temperature, precipitate the product by centrifugation, discard the supernatant, and collect the bottom precipitate, which is the obtained quantum dot product;

[0044] ⑥ Dissolve the precipitate in water to obtain Ag with a fluorescence emission wavelength of 1167 nm 2 S quantum dot solution.

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Abstract

The invention relates to a preparation method for a water-soluble Ag2S quantum dot. Thiohydracrylic acid is used as surface ligand, the hydrosulfuryl terminal is coordinated with Ag atom on the surface of Ag2S quantum dot, and the carboxyl terminal disassociates on the tail end of the thiohydracrylic acid, so that the prepared Ag2S quantum dot can be dissolved in a water phase. A particle size of the Ag2S quantum dot and a wavelength emitted by fluorescence can be controlled via controlling the reaction time and the concentration of a reactant. The prepared Ag2S quantum dot by the method provided by the invention is uniform in particle size and good in monodispersion, and a lot of Ag2S quantum dots can be repeatedly prepared, and can be more widely applied to the field of chemistry, biology, material science and the like.

Description

technical field [0001] The invention belongs to the field of chemistry and material science, and relates to a water-soluble Ag 2 Preparation method of S quantum dots. Background technique [0002] With the rapid development of semiconductor fluorescent nanomaterials (quantum dots) in recent years, people have gradually successfully applied them to biomedical labeling and imaging. Compared with traditional organic fluorescent dyes, quantum dots have superior fluorescence properties such as unary excitation, multiple emission, and strong photobleaching resistance, so they have broad application prospects in the field of biomedicine. At present, there are some shortcomings in the existing preparation technology: (1), the fluorescence emission wavelength of traditional quantum dots (such as CdSe, CdS) is in the visible light range, so it is difficult to avoid the interference of biological autofluorescence when used in biological systems , and it is difficult to mark deep tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/58C01G5/00
Inventor 庞代文姜鹏田智全
Owner WUHAN UNIV