Liquid iodine disinfectant, preparation method and used container thereof

A disinfection preparation, liquid technology, applied in the field of medicine, can solve the problems of affecting the iodine sterilization effect, large skin irritation, affecting the sterilization effect, etc., and achieve the effect of prolonging the disinfection and sterilization time, reducing skin irritation, and good killing effect.

Active Publication Date: 2012-09-19
山东沙多普生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the currently used iodine preparations have great defects: such as iodine (tincture of iodine), etc., have strong dyeing properties, allergies of excipients and low activity
The main reason for the low activity of the current iodine preparations is that the content of free iodine molecules in the entire iodine preparation is too low, and its content continues to decrease over time, while the content of other forms of iodine ions with weak bactericidal effects is low. very high
This not only affects the bactericidal effect of iodine, but also

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Dissolve 1 g of sodium iodide in water at room temperature, add 20 g of absolute ethanol, 0.1 g of menthol, and 0.1 g of methylparaben, make up 78.8 g of water, mix and dissolve completely to obtain solution 1. Dissolve 0.3g of potassium periodate in water at room temperature, add 3.5g of acidic pH regulator phosphoric acid, 20g of absolute ethanol, 0.1g of menthol, 0.1g of methylparaben, make up 76g of water, mix and dissolve completely Solution 2 was obtained.

[0063] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:10 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 10 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0064] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an a...

Embodiment 2

[0066] Dissolve 8g of sodium iodide in water at room temperature, add 25g of absolute ethanol, 0.2g of ethylparaben, make up 66.8g of water, mix and dissolve completely to obtain solution 1. Dissolve 2 g of sodium iodate in water at room temperature, add 20 g of tartaric acid, 25 g of absolute ethanol, and 0.2 g of ethylparaben, make up 52.8 g of water, mix and dissolve completely to obtain solution 2.

[0067] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:100 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 100 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0068] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 minutes ...

Embodiment 3

[0070] Dissolve 20g of magnesium iodide in water at room temperature, add water to 80g, mix and dissolve completely to obtain solution 1. Dissolve 5 g of potassium iodate in water at room temperature, add 15 g of phosphoric acid to make up 80 g of water, mix and dissolve completely to obtain solution 2.

[0071] When in use, mix and dissolve according to the ratio of solution 1, solution 2 and water at 1:1:100 (that is, 1 gram of solution 1 and 1 gram of solution 2 are dissolved in 100 grams of water), and then it can be made into a disinfectant Disinfect and sterilize.

[0072] After testing, the iodine disinfectant of this embodiment has an average killing logarithmic value of >5.00 for Candida albicans in 5 minutes, an average killing logarithmic value of >5.00 for Staphylococcus aureus in 5 minutes, and an average killing logarithmic value of Escherichia coli in 5 minutes >5.00.

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PUM

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Abstract

The invention discloses a liquid iodine disinfectant, a preparation method and a used container thereof. The liquid iodine disinfectant comprises iodide, an oxidant capable of oxidizing the iodide to generate iodine molecules, and a pH regulator used for regulating the mixture of the iodide and the oxidant to be acidic, the disinfectant consists of a preparation I containing the iodide and a preparation II containing the oxidant and the pH regulator, and the preparation I and the preparation II are both liquid. The liquid iodine disinfectant disclosed by the invention is good in stability, can be stored for a long time, has little skin irritation, can permeate fast and volatilize quickly, does not need deiodination, and is light in coloring, excellent in sterilization effect, and safe and convenient to use and carry. The liquid iodine disinfectant disclosed by the invention has broad spectrum bactericidal action and low irritation to the skin mucosa, so that the liquid iodine disinfectant can be applied to various skin diseases caused by bacteria, funguses and viruses.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a liquid iodine disinfection preparation for skin disinfection. Background technique [0002] Iodine is a commonly used disinfection product, especially preparations such as iodine (tincture of iodine) are familiar disinfection products, and are widely used in hospitals and daily life. Iodine is one of the broadest-spectrum disinfectants, which can kill 100% of various bacteria, fungi, viruses and other microorganisms without producing drug resistance. So far, no microorganisms resistant to iodine have been found in the world. [0003] However, there are great defects in the currently used iodine preparations: such as iodine (tincture of iodine) etc. have strong dyeing properties and allergies of auxiliary materials and low activity. The main reason for the low activity of the current iodine preparations is that the content of free iodine molecules in the entire iodine prepara...

Claims

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Application Information

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IPC IPC(8): A61K33/32A61K33/18A61K33/30A61K9/08A61K9/06A61P17/00A61P31/00
Inventor 郑中立孙国玲
Owner 山东沙多普生物科技有限公司
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