Isomaltose hypgather tablet excipient, medicine tablet and preparation method

A technology of isomaltose oligosaccharide and excipient, applied in the field of medicine, can solve the problems of high brittleness, cannot be pressed into tablets, etc., and achieves the effects of high hydrophilicity, good molding degree, and avoiding agglomeration and agglomeration

Inactive Publication Date: 2012-09-19
安吉东来药用辅料有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Example 8, ordinary microcrystalline cellulose was used as an excipient to carry out tablet compression of disodium clometris phosphate tablet. When the tablet compression speed reached 30,000 tablets / hour, the friability was as high as 38%. When reaching 50000 tablets / hour, then can not be compressed into tablet, carry out the disodium clomedipate tablet tabletting with silicified microcrystalline cellulose as excipient, when the tabletting speed reaches 50000 tablets / hour, although the tablet is still Maintain good strength, but the brittleness reaches 2.5%, and the brittleness is still high

Method used

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  • Isomaltose hypgather tablet excipient, medicine tablet and preparation method
  • Isomaltose hypgather tablet excipient, medicine tablet and preparation method
  • Isomaltose hypgather tablet excipient, medicine tablet and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0043]

[0044] Dry and pulverize isomaltooligosaccharide, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloromethicate and water and mix evenly, and use it in a tableting device for 9 ×20mm punching machine, made into anhydrous chlormedipate disodium pharmaceutical tablets with an average weight of 1185mg (±2%).

Embodiment 2

[0046] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0047]

[0048] Dry and pulverize isomaltooligosaccharide, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloromethicate and water and mix evenly, and use it in a tableting device for 9 ×20mm punching machine, made into anhydrous chlormedipate disodium pharmaceutical tablets with an average weight of 1185mg (±2%).

[0049] Prepare the anhydrous chlormedipate disodium pharmaceutical tablet (tablet A) of embodiment 1 and the anhydrous chlormedipate disodium pharmaceutical tablet (tablet B) of embodiment 2 under different tabletting speeds, and investigate Its crushing strength and fragility, the specific test results are shown in Table 1. The test of tablet crushing strength and friability refers to the method specified in the French Pharmacopoeia (10th edition in 1993, ...

Embodiment 3

[0054] A kind of anhydrous disodium clometris phosphate medicine tablet, adopts the raw material of following percentage by weight:

[0055]

[0056]

[0057] Dry and pulverize isomaltooligosaccharide, starch octenyl succinate, silicon dioxide and kaolin together and pass through a 1mm sieve, then add anhydrous disodium chloromethicate and water and mix evenly, and use it in a tableting device for 9 ×20mm punching machine, made into anhydrous chlormedipate disodium pharmaceutical tablets with an average weight of 1185mg (±2%).

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PUM

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Abstract

The invention discloses isomaltose hypgather tablet excipient, which consists of 88 percent to 96 percent of isomaltose hypgather, 1 percent to 5 percent of starch octenyl succinate anhydride, 1 percent to 5 percent of silicon dioxide and 1 percent to 5 percent of porcellanite in percentage by weight, and has the advantages that the mobility is good, the forming degree is good, the demolding performance is good, and isomaltose hypgather tablet excipient can be directly tableted with medicine and water for preparing medicine tablets. The invention also discloses a medicine tablet, which consists of 75 percent to 85 percent of medicine active ingredients, 5 percent to 15 percent of isomaltose hypgather tablet excipient and 5 percent to 15 percent of water raw materials in percentage by weight, wherein the isomaltose hypgather tablet excipient and the medicine active ingredients do not have incompatibility and reaction, in addition, the solvability is good, the flowability is good, and the medicine tablet is suitable for the direct tableting of various kinds of medicine. The invention also discloses a preparation method of the medicine tablet, which has the advantages that the preparation is simple, the implementation is easy, and the operation and the control are easy.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a directly compressible and easy-flowing isomalto-oligosaccharide tablet excipient prepared by using isomalto-oligosaccharide tablet excipient, and a pharmaceutical tablet prepared by using the isomalto-oligosaccharide tablet excipient And the preparation method of medicine tablet. Background technique [0002] Tablet accounts for more than one-third of all pharmaceutical dosage forms and is a very important pharmaceutical dosage form. Excipients play a vital role in drug stability and absorption efficiency, and are the core of drug tablet making. Appropriate tablet excipients are required to be safe, non-toxic, have no side effects, have no incompatibility or reaction with the main drug, and have good fluidity, so that the main drug can be dispersed evenly and have a large adsorption force to the main drug. It is suitable for direct tablet compression. The prepared tablet has the advan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/26A61K47/04A61K9/20
Inventor 阮晖李青青吴慧斌刘松柏陈放诸文颖
Owner 安吉东来药用辅料有限责任公司
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