Targeting radioactive micro/nano fluid preparation

A fluid preparation and radioactive technology, which is applied in the field of micro-nano materials and DNA markers, can solve the problems of skin and normal tissue damage, high radiation source intensity, and high operation requirements, and achieves easy control of drug dosage, good penetration, and easy operation methods. simple effect

Active Publication Date: 2012-09-26
TSINGHUA UNIV
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Problems solved by technology

External irradiation has relatively low requirements for equipment and doctors’ operating skills, but because the radiation must pass through the skin and normal tissues before it can be absorbed by the tumor, the radiation source needs to be strong and may cause damage to the skin and normal tissues; while internal irradiation can maximize As close to the tumor tissue as possible, the intensity of the radiation source required is small, and t

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  • Targeting radioactive micro/nano fluid preparation
  • Targeting radioactive micro/nano fluid preparation
  • Targeting radioactive micro/nano fluid preparation

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[0020] The present invention will be described in detail below in conjunction with the drawings.

[0021] A targeted radioactive micro-nano fluid preparation consisting of a solvent and micro-nano particles suspended in the solvent, sealed and stored in a radiation-proof container, injected through a radiation-proof needle tube, the mass concentration of the micro-nano particles is 1% -80%, the solvent and micro-nano particles have been disinfected and sterilized. The micro-nano particles are synthetic composite nanoparticles, or radioactive anaerobic bacteria with targeted colonization characteristics for tumors cultivated by DNA labeling technology, Or a radionuclide-labeled magnetosome produced by magnetotactic bacteria; the solvent is distilled water, physiological saline, water for injection, cell culture fluid, tissue fluid, or MISO, Kanglaite, SR-2508, AK-2123 with drug properties , 912, Maodongqing, Lycium barbarum polysaccharide, tetrandrine, paclitaxel solution.

[0022]...

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Abstract

A targeting radioactive micro/nano fluid preparation comprises solvent and micro/nano particles suspended in the solvent, is hermetically stored in a radiation-proof container, and injected through a radiation leakage-proof syringe. The solvent and micro/nano particles are both subjected to sterilization treatment. The preparation provided by the invention has the advantages of good targeting effect, good inter-tissue penetrability, easily controllable dosage, simple operation method, and greatly improved tumor treatment effect.

Description

technical field [0001] The invention relates to the technical field of micro-nano materials and DNA markers, in particular to a targeted radioactive micro-nano fluid preparation. Background technique [0002] At present, clinical radiation therapy mainly includes external radiation, internal radiation and radionuclide therapy. External irradiation has relatively low requirements for equipment and doctors’ operating skills, but because the radiation must pass through the skin and normal tissues before it can be absorbed by the tumor, the radiation source needs to be strong and may cause damage to the skin and normal tissues; while internal irradiation can maximize As close to the tumor tissue as possible, the intensity of the radiation source required is small, and the tumor tissue can absorb energy more effectively. However, the current technology makes the internal radiation have relatively high requirements for instruments and operations, and because of the need for a seal...

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Application Information

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IPC IPC(8): A61K51/02A61K51/12A61P35/00A61M36/06G21F5/018
Inventor 王倩刘静
Owner TSINGHUA UNIV
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