Poria peel extract and application of poria peel extract in preparation of diuretic medicines

A technology of poria cocos skin and extract, which is applied in the application field of preparing diuretic drugs, and can solve problems such as increasing cholesterol saturation, arrhythmia, and lowering

Inactive Publication Date: 2012-10-03
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the disadvantages of the current diuretics indapamide and furosemide are that a large number of applications can easily cause hypokalemia and arrhythmia; The disadvantage is that it often reduces the potassium content in the body. In addition, thiazide diuretics can increase the saturation of cholesterol in the patient's bile, which may increase the risk of cholecystitis

Method used

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  • Poria peel extract and application of poria peel extract in preparation of diuretic medicines
  • Poria peel extract and application of poria peel extract in preparation of diuretic medicines
  • Poria peel extract and application of poria peel extract in preparation of diuretic medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Poria Cortex Extract

[0021] Poria cocos skin is dried and crushed, soaked with 3-7 times the volume of 95% ethanol for 12-36 hours, and then percolated for 6 days, recovering ethanol, and concentrating to obtain a brown paste; the brown paste is dissolved in water, ethyl acetate Extract 4 times, recover ethyl acetate, and concentrate to obtain a paste; dissolve the paste in ethanol, mix the sample with silica gel, put it on a 100-200 mesh silica gel column, and use a volume ratio of petroleum ether-ethyl acetate of 7:3~ The 5:5 eluent was eluted, the eluate was collected, combined, concentrated, and finally the Poria cocos bark extract was obtained.

[0022] Determination of percolation time: Poria cocos skin is dried and crushed, soaked in ethanol, percolated, and percolated with 95% ethanol, and inspected for 1 day, 2 days, 3 days, 4 days, 5 days, 6 days and 7 days Effect of extraction time on extraction efficiency. The results showed th...

Embodiment 2

[0025] In order to verify the diuretic effect of Poria cocos bark extract, the inventor has carried out a pharmacodynamic test using a water retention rat model loaded with normal saline, and the various test conditions are as follows:

[0026] 1. Experimental drug

[0027] The Poria cocos extract (prepared in Example 1) suspension was prepared from tap water containing 2% gum arabic powder.

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Abstract

The invention discloses a poria peel extract, prepared by the following steps: step (1) of drying and grinding poria peels, then dipping with ethanol and percolating, recovering ethanol, and concentrating to obtain brown pastes; step (2) of dissolving the obtained brown pastes with water, extracting with ethyl acetate, recovering ethyl acetate and concentrating to obtain pastes; step (3) of dissolving pastes obtained in the step (2) in ethanol, mixing with silica gel, loading in silica gel column with 100-200 meshes, eluting with petroleum ether-ethyl acetate eluent, collecting eluent, combining and concentrating to obtain the poria peel extract at the last. The extract provided by the invention has potassium-sparing and sodium excretion actions; diuretic action time of the extract is longer than that of furosemide; and the extract is featured with long-acting performance, low toxic side effects and so on, so that a new candidate diuretic medicine is provided for clinic.

Description

technical field [0001] The invention relates to an extract of Poria cocos cortex and its application in the preparation of diuretic drugs, belonging to the technical field of medicine. Background technique [0002] Poria cocos is a polyporaceae fungus Poria cocos[ Poria cocos (Schw.) Wolf.] The outer skin of the sclerotium is mainly distributed in Asia (China, Japan, Korea, etc.), North America and other places. It was first recorded in "Shen Nong's Herbal Classic", and it was recorded in later "Chinese Materia Medica", "Chinese Medical Dictionary", and "Medical Qiyuan", and it was recorded in previous "Chinese Pharmacopoeia". "Compendium of Materia Medica" records that Poria Cortex "maintains edema and skin swelling, opens water channels, and opens interstitial muscles". "Sichuan Traditional Chinese Medicine" records that Poria cocos skin is "flat in nature, sweet and light in taste, non-toxic", and enters the kidney and bladder meridians. Mainly used for edema, dysuria...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61P7/10
Inventor 赵英永林瑞超程显隆魏锋孙文基
Owner NORTHWEST UNIV
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