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Stent

A main body and linear technology, applied in stents, coatings, medical science, etc., can solve problems such as difficulty in becoming spindle-shaped and growth of vascular endothelial cells, and achieve inhibition of damage, inhibition of delayed stent thrombosis, and promotion of cell the effect of growing up

Inactive Publication Date: 2012-10-03
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the stent described in Patent Document 1, since a substance having cell attachment ability is provided on substantially the entire inner surface of the stent, the attached vascular endothelial cells grow randomly, and it is difficult to form a spindle shape.

Method used

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Experimental program
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Effect test

no. 1 Embodiment approach

[0031] Such as Figure 1 ~ Figure 3 As shown, the stent 10 of the first embodiment of the present invention includes: a cylindrical stent body 12, which is formed by arranging and connecting a plurality of annular parts 11 along the axial direction, and these annular parts 11 are bent into a wave shape The ring-shaped wire rod is formed; the covering layer 13 is provided on the inner surface of each ring-shaped portion 11 . The stent 10 is a balloon-expandable structure. By disposing the stent 10 on a balloon of a balloon catheter and expanding the balloon, the stent main body 12 expands radially. When the stent main body 12 expands, plastic deformation occurs in which the buckling angle of each annular portion 11 increases, and the stent 10 is placed in the lesion while maintaining a state in which the outer surface spreads the living tissue or the like. Here, the outer surface of the stent main body 12 that is in contact with the living tissue refers to the side that is in ...

no. 2 Embodiment approach

[0054] Such as Figure 7 with Figure 8 As shown, the stent 20 of the second embodiment of the present invention differs from the stent 10 of the first embodiment only in that the extending direction of the linear covering portion 24 is different. In addition, parts having the same functions as in the first embodiment are assigned the same reference numerals as in the first embodiment, and description thereof is omitted to avoid duplication.

[0055] As in the first embodiment, the inner surface of the stent main body 12 is provided in a solid phase with a coating layer 23 containing a substance having a cell attachment ability capable of promoting cell attachment. The covering layer 23 is used to cover the inner surface of the stent main body 12 with vascular smooth muscle cells after the stent main body 12 is expanded and placed in the lesion.

[0056] Vascular smooth muscle cells are usually arranged in a helical shape to form blood vessels. Therefore, in order to make t...

Embodiment

[0062] Hereinafter, the present invention will be described in more detail using examples, but the present invention is not limited thereto.

[0063] Reference example

[0064] For the substrate (CoCr alloy) (manufactured by HIGHTEMPMETALS, model L605) such as Figure 10 with Figure 11 Set BD in stripes as shown TM PuraMatrix TM Peptide hydrogel (registered trademark) is a covering substrate 30 formed with a plurality of linear covering parts 34, and the covering substrate 30 and raw materials are the same as the above-mentioned (CoCr alloy) substrate by culturing cells. A comparative experiment was carried out on a base material (unprocessed base material) not provided with a covering portion. The width W of the linear covering portion 34 was set to 200 μm, and the distance D between adjacent linear covering portions 34 was set to 200 μm.

[0065] Cell cultures used vascular endothelial cells from normal human aorta. Cells were cultured in CSC-C medium supplemented ...

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Abstract

Provided is a stent wherein cells are directionally proliferated on the inner surface of the stent and thus the stent surface is quickly coated with the cells so that the onset of late stent thrombosis or restenosis can be prevented or reduced. The stent (10) comprises a cylindrical main stent body (12), which has openings at both ends and extends along the longitudinal direction (X) between said openings at the both ends, and a coating layer (13), which is provided on the inner surface of the main stent body (12) and contains a substance having a cell adhesion ability to promote the adhesion of cells, said coating layer (13) being formed by arranging multiple linear coating parts (14), each extending linearly, in a striped manner.

Description

technical field [0001] The present invention relates to a stent for maintaining a patency of a lesion, such as a stenosis or an obstruction, in a lumen of a living body by indwelling the lesion. Background technique [0002] The stent indwelling method has been used for a long time. The stent indwelling method is to indwell a hollow tubular tube in the lesions such as narrowed or obstructed parts of the lumen or body cavity in the living body such as blood vessels, bile ducts, esophagus, trachea, urethra, and other internal organs. The stent as a medical device maintains the patency of the lesion. [0003] Percutaneous transluminal coronary angioplasty (PTCA), to treat, for example, ischemic heart disease, is a procedure in which a small incision is made in an artery in the patient's foot or wrist and an introducer sheath (introducer) is placed in the In this artery, the guide wire is first inserted into the lumen of the introducer sheath and advanced in the lumen, and a lo...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61F2/04A61F2/89A61F2/91A61F2/915
CPCA61L2300/25A61F2/0077A61F2/91A61L31/16A61L31/10A61F2/82A61F2250/0068A61L2400/18A61L2300/252A61F2002/0086C08L89/00A61F2/844A61F2/915A61F2002/9155
Inventor 内山彩香斋藤昇名仓裕晶
Owner TERUMO KK
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