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Tablets comprising olmesartan medoxomil and method for preparing same

A technology of olmesartan medoxomil and tablets, which is applied in the field of western medicine preparations, can solve the problems of dissolution rate, low dissolution rate, and the inability to solve the problems of the taste of active ingredients, and achieve high dissolution rate, good taste, and improved stability and dissolution rate Effect

Active Publication Date: 2013-08-07
NANJING CHIA TAI TIANQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the dissolution problem of olmesartan medoxomil oral solid preparation, CN101066264A discloses a solid dispersion preparation of olmesartan medoxomil and a preparation method thereof, the preparation contains olmesartan medoxomil and selected from polyvinylpyrrolidone, povidone A solid dispersion of one or more of loxamer, polyethylene glycol, glyceryl monostearate, polyoxyl stearate, sucrose fatty acid ester, polyoxyethylene castor oil, although overcome The dissolution rate of olmesartan medoxomil is low, but it cannot solve the technical problem of poor taste caused by active ingredients

Method used

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  • Tablets comprising olmesartan medoxomil and method for preparing same
  • Tablets comprising olmesartan medoxomil and method for preparing same
  • Tablets comprising olmesartan medoxomil and method for preparing same

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Experimental program
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Effect test

Embodiment 1

[0021] The preparation of embodiment 1 olmesartan medoxomil tablet

[0022] Prescription composition:

[0023]

[0024] Preparation Process:

[0025] (1) Transfer the 400-micron spherical lactose pellet core to the fluidized bed system, add the prescribed amount of olmesartan medoxomil to 80% ethanol solution to dissolve, and spray the olmesartan medoxomil solution into the spherical lactose pellet Olmesartan medoxomil pellets were prepared in a fluidized bed with a core. Among them: during the pelletizing process, the inlet temperature is 35°C, the outlet temperature is 30°C, and the product temperature is 30°C; during the drying process, the inlet temperature is 45°C, the outlet temperature is 35°C, and the product temperature is 35°C; the spray speed is 6ml / min, and the spray pressure is 3bar.

[0026] (2) Weigh polyvinyl alcohol, polyethylene glycol triethyl citrate and talcum powder according to the weight ratio = 1:0.2:0.3, mix them, dissolve them in purified water...

Embodiment 2

[0028] The preparation of embodiment 2 olmesartan medoxomil tablets

[0029] Prescription composition:

[0030]

[0031] Preparation Process:

[0032] (1) Transfer the 400-micron spherical lactose pellet core to the fluidized bed system, add the prescribed amount of olmesartan medoxomil to 80% ethanol solution to dissolve, and spray the olmesartan medoxomil solution into the spherical lactose pellet Olmesartan medoxomil pellets were prepared in a fluidized bed with a core. Among them: during the pelletizing process, the inlet temperature is 35°C, the outlet temperature is 30°C, and the product temperature is 30°C; during the drying process, the inlet temperature is 45°C, the outlet temperature is 35°C, and the product temperature is 35°C; the spray speed is 6ml / min, and the spray pressure is 3bar.

[0033] (2) Weigh polyvinyl alcohol, polyethylene glycol triethyl citrate and talcum powder according to the weight ratio = 1:0.1:0.2, mix them, dissolve them in purified wate...

Embodiment 3

[0035] The preparation of embodiment 3 olmesartan medoxomil tablets

[0036] Prescription composition:

[0037]

[0038]

[0039] Preparation Process:

[0040] (1) Transfer the 400-micron spherical lactose pellet core to the fluidized bed system, add the prescribed amount of olmesartan medoxomil to 80% ethanol solution to dissolve, and spray the olmesartan medoxomil solution into the spherical lactose pellet Olmesartan medoxomil pellets were prepared in a fluidized bed with a core. Among them: during the pelletizing process, the inlet temperature is 35°C, the outlet temperature is 30°C, and the product temperature is 30°C; during the drying process, the inlet temperature is 45°C, the outlet temperature is 35°C, and the product temperature is 35°C; the spray speed is 6ml / min, and the spray pressure is 3bar.

[0041] (2) Weigh polyvinyl alcohol, polyethylene glycol triethyl citrate and talcum powder according to the weight ratio = 1:0.2:0.3, mix them, dissolve them in p...

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Abstract

The invention discloses tablets comprising olmesartan medoxomil and a method for preparing the tablets. The tablets are prepared from olmesartan medoxomil micro pills, a disintegrating agent, a filler and a lubricating agent, wherein the olmesartan medoxomil micro pills are prepared by dispersing the olmesartan medoxomil on the surfaces of ball-shaped lactose pill cores and wrapping by isolating coating. The olmesartan medoxomil is made into medicine-carrying micro pills, then the olmesartan medoxomil micro pills are wrapped by the isolating coating, and the olmesartan medoxomil micro pills are mixed with other medicinal accessories and directly pressed into the tablets, therefore, the purpose of covering the bad smell of the olmesartan medoxomil is achieved, and the stability and the dissolution rate of the medicine are improved.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to a tablet containing olmesartan medoxomil and a preparation method thereof. Background technique [0002] Olmesartan medoxomil (olmesartan medoxomi l) is an angiotensin Ⅱ (Ag Ⅱ) antagonist antihypertensive drug newly developed by Japan's Sankyo (Sankyo), and it has been listed for the first time in the United States. Olmesartan medoxomil is a substituted imidazole drug, which is significantly superior to other similar products such as losartan, valsartan, and irbesartan in terms of overall efficacy in reducing diastolic blood pressure. It has good drug tolerance and no cough side effects compared with ACE inhibitors, and is an oral safe and effective high-efficiency antihypertensive drug that is easily accepted by patients. [0003] The chemical name of olmesartan medoxomil is 2,3-dihydroxy-2-butenyl-4-(1-hydroxy-1-methylethyl)-2-butyl-1-[4-(2-1H -tetrazoli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/4178A61P9/12
Inventor 张翎吴鑫铧
Owner NANJING CHIA TAI TIANQING PHARMA
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