Novel dithiocarbamate derivative of chitosan and preparation method thereof
A technology of chitosan dithioamino and polysaccharide dithioamino, which is applied in the field of new chitosan dithiocarbamate derivatives and its preparation, can solve the problems of poor solubility and limited application, and achieve Solve the effect of poor solubility, improve antibacterial activity, and good solubility
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Embodiment 1
[0024] The preparation of embodiment 1 derivative 1
[0025] Add 16.1 grams of chitosan with a molecular weight of 230,000 and 4.0 grams of sodium hydroxide to 200 mL of ethanol, stir at room temperature for half an hour, add 8 mL of carbon disulfide dropwise, and continue the reaction for 4 hours. Drying at low temperature to obtain a yellow powder, which is chitosan dithiocarbamate sodium salt, i.e. derivative 1, the structural formula is shown in general formula I. The preparation of chitosan derivatives refers to the following documents: Riccardo A.A.Muzzarelli, F.T., Sabina Mariotti, Monica Emanuelli (1982). "Preparation and characteristic properties of dithiocarbamate chitosan, a chelating polymer." [J] CarbohydrateResearch 104 (2): 235-243 .Infrared spectrum shows: the infrared spectrum of chitosan derivative 1 ( figure 2 ) and the infrared spectrum of chitosan ( figure 1 ) compared to 1461, 937cm -1 It is the characteristic absorption peak of N-C=S, which proves th...
Embodiment 2
[0026] The preparation of embodiment 2 derivative 2
[0027] Add 4.0 grams of chitosan with a molecular weight of 230,000 and 1.4 grams of potassium hydroxide to 50 mL of ethanol, stir at room temperature for half an hour, add 2 mL of carbon disulfide dropwise, and continue the reaction for 4 hours. Drying at low temperature gives a yellow powder, which is chitosan dithiocarbamate potassium salt, i.e. derivative 2, and the structural formula is shown in general formula I. Infrared spectrum shows: the infrared spectrum of chitosan derivative 2 ( image 3 ) and the infrared spectrum of chitosan ( figure 1 ) compared to 1464, 942cm -1 It is the characteristic absorption peak of N-C=S, which proves that the synthesis of the target derivative 2 is successful.
Embodiment 3
[0028] The preparation of embodiment 3 derivative 3
[0029] Add 4.0 grams of chitosan with a molecular weight of 230,000 and 5.0 mL of concentrated ammonia water to 50 mL of ethanol, stir at room temperature for half an hour, add 2 mL of carbon disulfide dropwise, and continue the reaction for 4 hours. Dry to obtain light yellow powder, which is chitosan dithiocarbamate ammonium salt, namely derivative 3, and the structural formula is shown in general formula I. Infrared spectrum shows: the infrared spectrum of chitosan derivative 3 ( Figure 4 ) and the infrared spectrum of chitosan ( figure 1 ) compared to 1466, 939cm -1 It is the characteristic absorption peak of N-C=S, which proves that the synthesis of target derivative 3 is successful.
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