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Compound aminophylline rapidly disintegrating oral tablet

A technology of orally disintegrating tablets and compound aminophylline, which is applied in the field of compound aminophylline orally disintegrating tablets and its preparation, can solve the problems of inconvenient medication and easy vomiting of dogs and cats, and achieve easy scale-up production and reduce pain, life-prolonging effect

Inactive Publication Date: 2012-10-17
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The patent (CN101190198A, published on June 4, 2008) provides a chewable aminophylline tablet for dogs and cats and its preparation method, which mainly consists of aminophylline, aspartame, oral glucose and skimmed milk powder. Make dogs and cats fully chew and absorb completely, but it is inconvenient to use clinically, and dogs and cats are easy to spit out after taking it

Method used

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  • Compound aminophylline rapidly disintegrating oral tablet
  • Compound aminophylline rapidly disintegrating oral tablet
  • Compound aminophylline rapidly disintegrating oral tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Party:

[0020]

[0021] Preparation:

[0022] (1) Get each component, after being crushed respectively, pass through a 100-mesh fine sieve three times, and set aside;

[0023] (2) Weigh each component according to the prescription amount, dilute pimobendan, micropowder silica gel, menthol and mannitol for three times, and then mix it with aminophylline, microcrystalline cellulose, low-substituted hydroxyl Propyl cellulose, povidone K30, camphor, and remaining mannitol are mixed evenly, and compressed into 2000 tablets.

[0024] (3) Dry the pressed tablet at 60°C for 30 minutes under reduced pressure, evaporate the camphor to dryness, and pack it to obtain.

Embodiment 2

[0026] Party:

[0027]

[0028] Preparation:

[0029] (1) Get each component, after being crushed respectively, pass through a 100-mesh fine sieve three times, and set aside;

[0030] (2) Take each component according to the amount of the recipe, dilute pimobendan, micropowder silica gel, menthol and mannitol with the same amount of incremental dilution three times, and then mix it with aminophylline, microcrystalline cellulose, povidone K30, camphor, and remaining mannitol are mixed evenly, and compressed into tablets to make 2000 tablets.

[0031] (3) Dry the pressed tablet at 60°C for 30 minutes under reduced pressure, evaporate the camphor to dryness, and pack it to obtain.

Embodiment 3

[0033] Party:

[0034]

[0035] Preparation:

[0036] (1) Get each component, after being crushed respectively, pass through a 100-mesh fine sieve three times, and set aside;

[0037] (2) Weigh each component according to the amount of the recipe, dilute pimobendan, micropowder silica gel, menthol and mannitol in equal increments for five times, and then mix them with aminophylline and cross-linked carboxymethyl cellulose Sodium, povidone K30, camphor, and remaining mannitol are mixed uniformly, compressed into tablets, and made into 2000 tablets.

[0038] (3) Dry the pressed tablet at 60°C for 30 minutes under reduced pressure, evaporate the camphor to dryness, and pack it to obtain.

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Abstract

The invention discloses a compound aminophylline rapidly disintegrating oral tablet and its preparation technology and belongs to the field of veterinary drug preparation. The compound aminophylline rapidly disintegrating oral tablet provided by the invention is prepared from the following components of: by weight, 25-200 parts of aminophylline, 1-8 parts of Vetmedin, 150-400 parts of a disintegrating agent, 270-750 parts of a diluent, 70-100 parts of polyvinylpyrrolidone K30, 2-10 parts of a lubricant, 2-12 parts of menthol and 100 parts of camphor. In comparison with other inventions, the compound aminophylline rapidly disintegrating oral tablet provided by the invention can more comprehensively treat cardiogenic cough and asthma of old dogs and cats. The rapidly disintegrating oral tablet prepared by direct compression can be convenient for drug administration, thus bringing great convenience for the application in pet clinic.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a compound aminophylline orally disintegrating tablet and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, keeping pets has become more and more common. However, in the process of keeping pets, the heart function of elderly dogs and cats becomes more and more fragile with age. Therefore, elderly dogs and cats often suffer from Asthma caused by heart failure. Aminophylline is an antiasthmatic drug, and its chemical name is 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione-1,2-ethylenediamine salt dihydrate. Aminophylline can directly act on bronchial smooth muscle, relieve spasm, and achieve the purpose of relieving cough. Therefore, aminophylline has remarkable efficacy in asthma and bronchial asthma, and is often used as the drug of choice. Pimobendan is mainly used for dogs and cats with acute heart failure o...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61K31/501A61K9/20A61P11/06A61P11/14A61P9/04
Inventor 魏德宝谷健王小武
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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