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L-calcium aspartate and its preparation method

A technology of calcium aspartate and aspartic acid, which is applied in the field of medicine, can solve the problems of cumbersome methods, unfavorable industrial production, and many steps, and achieve the effects of high yield, great application value, and simple methods

Inactive Publication Date: 2012-10-17
上海腾瑞医药技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is cumbersome and involves many steps, which is not conducive to industrial production

Method used

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  • L-calcium aspartate and its preparation method
  • L-calcium aspartate and its preparation method
  • L-calcium aspartate and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] L-Aspartic Acid 15.7kg

[0024] Calcium carbonate 5.9kg

[0025] Purified water 65.7kg

[0026] Preparation:

[0027] (1) Add 44.9kg of purified water into the reaction pot, put in L-aspartic acid and calcium carbonate, then add 20.8kg of purified water, heat while stirring, and keep the temperature of the reaction liquid at 75-85°C for 1.5 hours;

[0028] (2) Let the reacted feed liquid stand still for 10 hours (25°C), filter, and take the supernatant;

[0029] (3) The supernatant was spray-dried, and the dry powder was collected to obtain 17.6 kg of calcium L-aspartate, with a yield of 97.50%. Calcium content 12.2%

[0030] (The detection method is based on the Shanghai Enterprise Standard Q / VAGH 5-2007 index: Calcium (calculated as Ca2+), 12±1%)

Embodiment 2

[0032] L-Aspartic Acid 15.7kg

[0033] Calcium carbonate 6.79kg

[0034] Purified water 65.7kg

[0035] Preparation:

[0036] (1) Add 44.9kg of purified water to the reaction pot, add L-aspartic acid and calcium carbonate, then add 20.8kg of purified water, heat while stirring, and keep the temperature of the reaction solution at 75-85°C for 2.5 hours;

[0037] (2) Let the reacted feed liquid stand still for 18 hours (25°C), filter, and take the supernatant;

[0038] (3) The supernatant was spray-dried, and the dry powder was collected to obtain calcium L-aspartate (17.2Kg). The yield is 99.50%. Calcium content 12.6%.

Embodiment 3

[0040] L-Aspartic Acid 15.7kg

[0041] Calcium carbonate 7.67kg

[0042] Purified water 65.7kg

[0043] The preparation method is the same as in Example 1.

[0044] The yield of calcium L-aspartate is 98.50%. Calcium content 12.1%

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Abstract

The invention provides L-calcium aspartate. The L-calcium aspartate comprises the following components, by weight, 0.9-1.1 parts of L-aspartic acid, 0.4-0.5 part of calcium carbonate and 4.2 parts of pure water. The L-calcium aspartate the invention, which is used as a nutrition intensifying agent, enters the small intestine after stably going through the stomach, and slowly releases calcium ions for being absorbed by human bodies, the molecular structure of the L-calcium aspartate is similar to the molecular structure of dipeptide protein calcium which is in natural foods and is most easily absorbed by the intestinal tract, and results of Shanghai disease control center detection show that the content of blood calcium in the L-calcium aspartate is 84.5mug / ml and the content of blood calcium in a blank control group is 6.6mug / ml. By statistical processing, the difference has a significance (P is less than 0.005). The method has the advantages of less relating equipment and simplicity, and allows the yield of the L-calcium aspartate to reach 99.50%; and the calcium content is 12.1-12.6%, so the method is suitable for industrialized production and has a large application value.

Description

technical field [0001] The invention relates to medicines, in particular to calcium L-aspartate and a preparation method thereof. Background technique [0002] Calcium is the basic raw material for bone development and has other important physiological functions in the body. These functions play an important role in maintaining the health of the body and ensuring the smooth progress of normal growth and development. For example, calcium can promote the activity of certain enzymes in the body, regulate the activity of enzymes; participate in the activity of nerves and muscles and the release of neurotransmitters; regulate the secretion of hormones. Calcium is also needed for blood coagulation, cell adhesion, and muscle contraction. Calcium also has the functions of regulating heart rhythm, reducing cardiovascular permeability, controlling inflammation and edema, and maintaining acid-base balance. CN1817855A has reported the preparation method of L-aspartic acid chelated ca...

Claims

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Application Information

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IPC IPC(8): C07C229/24C07C227/18A61P3/02
Inventor 叶桃陆燕萍周健谢松
Owner 上海腾瑞医药技术有限公司
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