Silicone-free high elasticity coated drug bottle plug and manufacturing method

Abstract

The invention discloses a silicone-free high elasticity coated drug bottle plug and a manufacturing method, comprising a plug crown and a plug neck, wherein annular elastic ports are arranged on the lower end part of the plug crown, and a coating layer is arranged to cover the whole bottle plug. The height of one annular elastic port is equal to the thickness of a film partition side; the height of the second annular elastic port is the summation of the height of an annular elastic boss and the thickness of the film partition side; and the annular elastic boss is placed on the outer side of the plug crown. The method for manufacturing the silicone-free high elasticity coated drug bottle plug is as follows: 1) with adoption of a routine process, vulcanizing and forming integrated rubber sheets which are connected with a plurality of bottle plugs or the integrated rubber sheets which are connected with the plural bottle plugs with the annular elastic bosses via the film partition sides through a bottle plug mould; coating the whole integrated rubber sheets; and 3) annularly punching the integrated rubber sheets which are coated at punching points to obtain a finished product of the silicone-free high elasticity coated drug bottle plug. Compared with the existing bottle plug, the drug bottle plug produced by the invention is of better drug compatibility.

Description

technical field [0001] The invention relates to a drug bottle stopper in the technical field of medical packaging materials, in particular to a non-siliconized and highly elastic coated drug bottle stopper and a manufacturing method thereof. Background technique [0002] As we all know, medicinal bottle stoppers are elastic packaging materials that are directly in contact with drugs, which directly affect the quality and storage period of drugs. Especially with the advent of new and special drugs, the problem of compatibility between bottle stoppers and drugs has become more prominent. Such as sodium bicarbonate injection, injections extracted from traditional Chinese medicine, some cephalosporin antibiotics, antineoplastic drugs, etc. In order to solve the compatibility problem between the bottle stopper and the drug, in the prior art, one is to coat the neck part of the bottle stopper with the drug in direct contact with polytetrafluoroethylene film; the other is to use va...

AI Technical Summary

Problems solved by technology

Although the above method solves the drug compatibility problem better by protecting the contact part of the bottle stopper and the drug, there are also disadvantages that are difficult to overcome in the above two methods.

Disadvantages of the first method: 1) The secondary molding process is required, the process is complicated, and the production efficiency is low; and because of the limited ductility of the PTFE film, the possibility of film rupture is extremely high, which affects the reliability of use. There are quality risks; 2) It is only suitable for bottle stoppers with relatively simple structural shapes. For complex shapes, the manufacturing cost is high and the product yield is extremely low; 3) In order to meet the needs of the packaging process, siliconization is still required, and there is silicone oil to drug compatibility. Impact

Although the second method better solves the compatibility problem of medicines and avoids the use of silicone oil, it still has the following disadvantages: the coating layer completely covers the bottle stopper, resulting in less elastic deformation of the bottle stopper during use, and it is easy to get stuck between the cork crown and the bottle stopper. Leakage is formed at the sealing joint of the bottle mouth, which leads to poor sealing performance of the bottle stopper on the medicine, and affects safety and reliability

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