Preparation method for taxifolin

Abstract

The invention relates to a preparation method for taxifolin, which comprises the following g steps: adding crushed larix gmelini and water in a reaction vessel for reacting, physically separating the solid and the liquid to obtain an activated larix gmelini solid, adding the activated larix gmelini solid and water in the reaction vessel for reacting and physically separating the solid and the liquid to obtain a solution, passing the solution through a chromatography column, injecting glycerol in a chromatography column for washing to obtain an eluate, and distilling and crystallizing the eluate to obtain taxifolin. One time distillation is required in the preparation technology, the energy consumption due to excessive distillation frequency can be reduced, the energy can be saved, the cost of glycerol used for washing is low, the washing capability is strong and the amount is less, the generation cost is reduced, and the glycerol enables non toxicity, no damage is generated on the human body and environment during the production process, the taxifolin without toxicity can be obtained, the solid-liquid separation employs the physical separation, and the separating operation is simple, the chemical separating with other impurities introduction can be avoided, and the purity after crystallization is greater than 99%.

Description

technical field [0001] The invention relates to a production method of flavonoids, in particular to a production method of dihydroquercetin. Background technique [0002] Dihydroquercetin is a kind of bioflavonoid, which has strong antibacterial effect on Staphylococcus aureus, Escherichia coli, Shigella and Salmonella typhi, and has anticancer effect at the same time. At present, the method for preparing dihydroquercetin uses grape seeds or yew branches and leaves. These two raw materials are expensive, the production cost is high, and the obtained product has low purity, which is suitable for laboratory preparation and is not convenient for industrialization. In the method for preparing dihydroquercetin in the publication number CN101157733A, although larch is used as a raw material, the preparation process requires multiple distillations, which consumes a lot of energy, and ethers or lipids are used for extraction, and the price of the extractant is relatively high. It ...

AI Technical Summary

Problems solved by technology

At present, the method for preparing dihydroquercetin uses grape seeds or yew branches and leaves. These two raw materials are expensive, the production cost is high, and the product obtained is low in purity, which is suitable for laboratory preparation and is not convenient for industrialization.

In the method for preparing dihydroquercetin in the publication number CN101157733A, although larch is used as a raw material, the preparation process requires multiple distillations, which consumes a lot of energy, and ethers or lipids are used for extraction, and the price of the extractant is relatively high. Has certain toxicity, and the production cost is large

In the method for preparing dihydroquercetin in the publication number CN101993429A, ethanol is used for adsorption and elution, the amount of ethanol used is large, the elution time is long, and the production cost is high