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Method for extracting khellin from ammi visnaga

An extraction technology of fennel, which is applied in the field of extraction and separation of flavonoids, can solve the problems of unsuitability for industrial production, complicated process, and high cost, and achieve the effects of low production cost, simple process, and avoiding column separation

Active Publication Date: 2015-02-11
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a method for extracting kelp from fennel, which mainly solves the problems of complicated process, low yield, high cost and unsuitability for industrial production in the existing method of extracting kelp from fennel.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1] extract

[0026] Take 1000g of Amy fennel raw material, use 5 times the mass of ethanol solution with a concentration of 90%, extract 3 times in an environment of 80°C, and each extraction time is 2 hours;

[0027] 2] concentrated

[0028] After combining the extracts extracted in step 1, concentrating to no alcohol to obtain a concentrated solution;

[0029] 3] Extraction

[0030] The concentrated solution obtained after the concentrated treatment in step 2 is extracted with dichloromethane, and the quality of dichloromethane is 5 times that of the concentrated solution, and a total of 3 extractions are performed;

[0031] 4] Primary crystallization

[0032] Concentrate the extract obtained by extraction in step 3 to 0.3 times the original volume, then add an equal volume of methanol solution with a concentration of 80% and stir. After stirring evenly, place it for crystallization for 24 hours. Filter and dry to obtain primary crystallization;

[0033] 5] Secon...

Embodiment 2

[0036] 1] extract

[0037] Take 1000g of Amelia raw material, use 8 times the mass of ethanol solution with a concentration of 80%, and extract 3 times in an environment of 60°C, and the extraction time is 1.5 hours each time;

[0038] 2] concentrated

[0039] Combining the extracts extracted in step 1 and concentrating them to no alcohol to obtain a concentrated solution;

[0040] 3] Extraction

[0041] The concentrated solution obtained after the concentrated treatment in step 2 is extracted with a mixed solvent of dichloromethane and ethyl acetate = 30:1, the quality of the mixed solvent is 6 times the quality of the concentrated solution, and a total of 2 extractions;

[0042] 4] Primary crystallization

[0043] Concentrate the extract obtained by extraction in step 3 to 0.5 times the original volume, then add an equal volume of methanol solution with a concentration of 60% and stir, after stirring evenly, place the crystal for 24 hours, filter, and dry to obtain primar...

Embodiment 3

[0047] 1] extract

[0048] Take 1000g of Amy fennel raw material, use 4 times the mass of ethanol solution with a concentration of 85%, extract twice in an environment of 80°C, and each extraction time is 2 hours;

[0049] 2] concentrated

[0050] Combining the extracts extracted in step 1 and concentrating them to no alcohol to obtain a concentrated solution;

[0051] 3] Extraction

[0052] The concentrated solution obtained after the concentrated treatment in step 2 is extracted with ethyl acetate, the quality of ethyl acetate is 8 times that of the concentrated solution, and a total of 3 extractions;

[0053] 4] Primary crystallization

[0054] Concentrate the extract obtained by extraction in step 3 to 0.2 times the original volume, then add an equal volume of ethanol solution with a concentration of 80% and stir, after stirring evenly, place the crystal for 15 hours, filter, and dry to obtain primary crystal;

[0055] 5] Secondary crystallization

[0056] Dissolve th...

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PUM

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Abstract

The invention provides a method for extracting khellin from ammi visnaga, to mainly solve the problems of complex process, low yield, high cost and unsuitability for industrial production of the existing method when khellin is extracted from ammi visnaga. The method for extracting khellin from ammi visnaga comprises the following steps: 1) abstracting, 2) concentrating, 3) extracting, 4) primary crystallizing, 5) secondary crystallizing. According to the method for extracting khellin from ammi visnaga, khellin product with purity of more than 90% is obtained only by a few steps. The method provided by the invention is simple, effective and low in production cost, and can avoid using column separation. The process is simple, and the yield is high. The final yield of product can reach more than 80%, and the method is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of extraction and separation of flavonoids, in particular to a method for extracting and separating kelp from Amelia fennel. Background technique [0002] Amy fennel is the seed of the genus Ami in the Umbelliferae family, mainly produced in Morocco. Its extract has the functions of treating angina pectoris, asthma, vitiligo, spasm, coronary artery vasodilation, and bronchiectasis. [0003] As one of the main active ingredients in Fennel, there are few reports on its extraction and separation. It has been reported in foreign literature that a small amount of Kelin can be obtained by extracting with dichloromethane or ethanol, concentrating without alcohol, extracting with chloroform, and separating by electrophoresis. Extraction and separation of large production. Contents of the invention [0004] The invention provides a method for extracting kelp from fennel, which mainly solves the problems of complex process,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/04
Inventor 王春德肖红王晓莹
Owner SHAANXI JIAHE PHYTOCHEM