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Extractive of fructus schisandrae and preparation method and application thereof

A technology of Schisandra chinensis and extract, applied to Schisandra chinensis extract and its preparation and application fields, can solve problems such as waste, and achieve the effects of reducing waste, unique activity and high lignan content

Active Publication Date: 2012-10-31
吉林省华惠生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In my country, the fruits and seeds of Schisandra chinensis have been used as medicine for a long time, and many parts other than the seeds of Schisandra chinensis are used, resulting in a very large waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: 1 kg of Schisandra root was soaked in 8L of water at 60°C for 12 hours, the water was released, the root of Schisandra was taken out and dried, and the dried root of Schisandra was extracted twice with 6L of 90% ethanol, 5L of reflux, and the ethanol extracts were combined ; Filtrate, concentrate the medicinal material and the extract ratio is 1.5L, add water to 3L to disperse the ethanol concentrate, carry out steam distillation, accept the steam distillate at 1 times the weight of the medicinal material, continue to concentrate to 1L, leave the extract overnight, separate In the lower water layer, add 0.3L of 90% ethanol to the above extract and concentrate to obtain 115g of Schisandra chinensis root ethanol extract.

[0026] 115g of the above-mentioned ethanol extract of Schisandra chinensis root was put on the column with 500g of macroporous adsorption resin, washed with water until colorless, eluted with 50% ethanol for two column volumes, then eluted wit...

Embodiment 2

[0027] Example 2: 100 g of the rhizome xylem of Schisandra chinensis, soaked in 800ml, 95% ethanol for 12 hours, reflux extraction for 2 hours, then reflux extraction with 600ml of 95% ethanol for 1.5 hours, combined ethanol extract; filtered, concentrated to obtain ethanol from the rhizome of Schisandra chinensis Extract 10.5g. The ethanol extract of the rhizome xylem of Schisandra chinensis is refined with macroporous adsorption resin, take 30g of macroporous adsorption resin, first wash with water until colorless, then wash with 300ml of 60% ethanol, and finally elute with 400ml of 95% ethanol, collect 95% ethanol to wash Deliquoring, recovering ethanol under reduced pressure to obtain 3.25 g ethanol extract of Schisandra rhizome xylem, containing 18% (mass percentage) schisandrin A. The determination of the content is to use Schisandra Methanol as the reference substance, and to measure it by high performance liquid chromatography. The chromatographic conditions are: chromat...

example 3

[0028] Example 3 The hangover experiment of the extract of Schisandra chinensis. The application of the Schisandra chinensis extract of the present invention in hangover protection and liver protection is proved by the following experiment (the effect of Schisandra schisandra root and xylem rhizome extract on the whole blood ethanol content of mice).

[0029] Materials and Methods

[0030] 1.1 Experimental materials

[0031] 1.1.1 Experimental samples and reagents were provided by the Animal Room of Yanbian University School of Medicine. Schisandra chinensis root ethanol extract and Schisandra rhizome xylem ethanol extract homemade. Liquor used in the experiment: Erguotou liquor, alcohol content 50% (v / v). Bought in a supermarket, use an alcohol meter to measure its alcohol content (unchecked). Ethanol standard solution: make 0.02mg / ml with distilled water

[0032] 1.1.2 Experimental animals: Kunming mice, half male and half male, weighing 8-22g.

[0033] 1.1.3 Experime...

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PUM

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Abstract

The invention discloses an extractive of fructus schisandrae and particularly relates to an ethanol extractive extracted from roots of fructus schisandrae and containing 15% of schizandrin or an ethanol extractive extracted from xylem of rhizome of fructus schisandrae and containing 18% of schizandrin. By means of the extractive, the problem of shortage in the fructus schisandrae raw material is solved, resources of the roots of the fructus schisandrae and the abandoned xylem of the rhizome of the fructus schisandrae in processing are made full use of, and waste is reduced. The extractive of fructus schisandrae is high in content of lignans such as schizandrin and different in content and composition of lignans compared with fruits and rattan of the fructus schisandrae and has unique activity in pharmacological activity. The invention further discloses the preparation method of the extractive of fructus schisandrae and the application of the extractive of fructus schisandrae in the aspect of hangover cure and liver protection.

Description

technical field [0001] The invention relates to an extract of Schisandra chinensis and its preparation method and application. Background technique [0002] Schisandra chinensis (Schisandra chinensis (Turcz.) Baill) root is the root of Schisandra chinensis (Turcz.) Baill. Schisandra chinensis has a long-standing reputation at home and abroad. It tastes sour, sweet, and warm in nature. Commonly used precious Chinese herbal medicines in my country have the functions of nourishing qi, nourishing the kidney, astringing the lungs, astringent essence, promoting body fluid, quenching thirst, improving intelligence, and calming the nerves. They are mainly used in the treatment of chronic hepatitis, insomnia, dreamy palpitations and other diseases. Pharmacological studies have proved that Schisandra chinensis has the functions of protecting the liver, anti-aging, improving cardiovascular disease, anti-inflammation, anti-oxidation, calming the nerves, and enhancing immunity. The che...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P1/16A61P39/02A61P37/04A61P39/06A61K125/00
Inventor 金光洙雒佳
Owner 吉林省华惠生物科技有限公司
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