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Formula of medical biocolloid solution and preparation method thereof

A technology of biological glue and body fluids, which is used in medical science, bandages, absorbent pads, etc.

Inactive Publication Date: 2012-10-31
GUIZHOU YANGSHENG MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there is no preparation technology for medical biological colloid preparations that can achieve industrialized mass production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Sodium polyglucosamine carboxylate 0.2%

[0026] Sodium chloride 0.9%

[0027] Water for injection 98.9%

[0028] Preparation:

[0029] (1) Wash polyglucosamine sodium carboxylate with ethanol according to the percolation method to remove alcohol-soluble substances, then dry at low temperature to remove ethanol residues, then dissolve in water for injection to obtain solution ①, set aside;

[0030] (2) Sodium chloride, or potassium nitrate, or sodium nitrate, or glycochloric acid, or mannitol, which is a substance for regulating osmotic pressure, is directly dissolved in water for injection to obtain a solution ②, and set aside;

[0031] (3) After mixing solution ① and solution ②, add water for injection to a sufficient amount;

[0032] (4) The solution obtained in step (3) is subjected to initial filtration, fine filtration, and aseptic filling to obtain a medical biological colloid.

Embodiment 2

[0034] Sodium polyglucosamine carboxylate 0.6%

[0035] Potassium nitrate 1.0%

[0036] Water for injection 98.4%

[0037] Preparation:

[0038] (1) Wash polyglucosamine sodium carboxylate with ethanol according to the percolation method to remove alcohol-soluble substances, then dry at low temperature to remove ethanol residues, then dissolve in water for injection to obtain solution ①, set aside;

[0039] (2) Sodium chloride, or potassium nitrate, or sodium nitrate, or glycochloric acid, or mannitol, which is a substance for regulating osmotic pressure, is directly dissolved in water for injection to obtain a solution ②, and set aside;

[0040] (3) After mixing solution ① and solution ②, add water for injection to a sufficient amount;

[0041] (4) The solution obtained in step (3) is subjected to initial filtration, fine filtration, and aseptic filling to obtain a medical biological colloid.

Embodiment 3

[0043] Sodium polyglucosamine carboxylate 0.5%

[0044] Sodium nitrate 1.1%

[0045] Water for injection 98.4%

[0046] Preparation:

[0047] (1) Wash polyglucosamine sodium carboxylate with ethanol according to the percolation method to remove alcohol-soluble substances, then dry at low temperature to remove ethanol residues, then dissolve in water for injection to obtain solution ①, set aside;

[0048] (2) Sodium chloride, or potassium nitrate, or sodium nitrate, or glycochloric acid, or mannitol, which is a substance for regulating osmotic pressure, is directly dissolved in water for injection to obtain a solution ②, and set aside;

[0049] (3) After mixing solution ① and solution ②, add water for injection to a sufficient amount;

[0050] (4) The solution obtained in step (3) is subjected to initial filtration, fine filtration, and aseptic filling to obtain a medical biological colloid.

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PUM

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Abstract

The invention discloses a formula of a medical biocolloid solution and a preparation method thereof. The medical biocolloid solution comprises the following components in percentage by weight: 0.1-2.5% of polyglucosamine sodium carboxylate, 0.6-0.9% of sodium chloride or 0.8-1.2% of potassium nitrate or 0.8-1.4% of sodium nitrate or 0.9-2.2% of glycine or 2.6-4.8% of mannitol, and the balance of water for injection. The preparation method comprises the following steps: (1) washing the polyglucosamine sodium carboxylate with ethanol by a percolation process to remove alcohol-soluble substances, baking at low temperature to remove ethanol residues, and dissolving in water for injection to obtain a solution (1) for later use; (2) directly dissolving the sodium chloride, or potassium nitrate, or sodium nitrate, or glycine or mannitol for regulating osmotic pressure in water for injection to obtain a solution (2) for later use; (3) mixing the solution (1) and the solution (2), and adding water for injection to full dose; and (4) carrying out preliminary filtration, fine filtration and sterile filling on the solution obtained in the step (3), thereby obtaining the medical biocolloid solution.

Description

technical field [0001] The present invention relates to pharmaceutical formulations characterized by a particular physical shape, in particular to a liquid formulation for surgical use. Background technique [0002] Laparotomy or laparoscopic surgery will cause different degrees of adhesions. Postoperative adhesions refer to the abnormal structure formed by the combination of connective tissue fibers and adjacent tissues or organs. It is a common clinical phenomenon in surgical operations. It is an inevitable pathophysiological process of the postoperative healing process, and postoperative adhesion is a common problem in departments such as obstetrics and gynecology, general surgery, cardiothoracic surgery, and orthopedics. Surgical trauma, ischemia, bleeding and infection can cause postoperative adhesions. Complications caused by peritoneal adhesions mainly include intestinal obstruction, infertility, and chronic pelvic pain, which have become a difficult problem in surge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/50A61L15/28
Inventor 郑茂鑫黄昌平聂开品
Owner GUIZHOU YANGSHENG MEDICAL INSTR
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