Formula of medical biocolloid solution and preparation method thereof

Abstract

The invention discloses a formula of a medical biocolloid solution and a preparation method thereof. The medical biocolloid solution comprises the following components in percentage by weight: 0.1-2.5% of polyglucosamine sodium carboxylate, 0.6-0.9% of sodium chloride or 0.8-1.2% of potassium nitrate or 0.8-1.4% of sodium nitrate or 0.9-2.2% of glycine or 2.6-4.8% of mannitol, and the balance of water for injection. The preparation method comprises the following steps: (1) washing the polyglucosamine sodium carboxylate with ethanol by a percolation process to remove alcohol-soluble substances, baking at low temperature to remove ethanol residues, and dissolving in water for injection to obtain a solution (1) for later use; (2) directly dissolving the sodium chloride, or potassium nitrate, or sodium nitrate, or glycine or mannitol for regulating osmotic pressure in water for injection to obtain a solution (2) for later use; (3) mixing the solution (1) and the solution (2), and adding water for injection to full dose; and (4) carrying out preliminary filtration, fine filtration and sterile filling on the solution obtained in the step (3), thereby obtaining the medical biocolloid solution.

Description

technical field [0001] The present invention relates to pharmaceutical formulations characterized by a particular physical shape, in particular to a liquid formulation for surgical use. Background technique [0002] Laparotomy or laparoscopic surgery will cause different degrees of adhesions. Postoperative adhesions refer to the abnormal structure formed by the combination of connective tissue fibers and adjacent tissues or organs. It is a common clinical phenomenon in surgical operations. It is an inevitable pathophysiological process of the postoperative healing process, and postoperative adhesion is a common problem in departments such as obstetrics and gynecology, general surgery, cardiothoracic surgery, and orthopedics. Surgical trauma, ischemia, bleeding and infection can cause postoperative adhesions. Complications caused by peritoneal adhesions mainly include intestinal obstruction, infertility, and chronic pelvic pain, which have become a difficult problem in surge...

AI Technical Summary

Problems solved by technology

However, so far, there is no preparation technology for medical biological colloid preparations that can achieve industrialized mass production.