Application of tanshinone IIA in reduction of arsenic content in body blood

A technology of tanshinone and content, applied in the field of medicine, can solve problems such as satisfying the curative effect of arsenic discharge

Inactive Publication Date: 2014-04-09
SHANGHAI UNIV OF T C M +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment methods for arsenic poisoning mainly include selenium supplementation, arsenic repelling with mercapto groups, and traditional Chinese medicine.

Method used

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  • Application of tanshinone IIA in reduction of arsenic content in body blood
  • Application of tanshinone IIA in reduction of arsenic content in body blood
  • Application of tanshinone IIA in reduction of arsenic content in body blood

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] 1. Materials and methods

[0007] 1.1 Experimental animals

[0008] The experimental animals were male Sprague-Dawley rats, male, weighing 320g-370g, provided by Shanghai Slack Experimental Animal Co., Ltd., and the production license number was SCXK (Shanghai) 2007-0005.

[0009] The breeding environment is an ordinary laboratory animal room, the temperature is 22°C-23°C, the relative humidity is 40%-70%, and the use license number is SCXK (Shanghai) 2006-0003.

[0010] 1.2 Drugs and reagents

[0011] (1) As standard stock solution 1g L -1 (As standard stock solution, 1g L -1 ): Provided by Merck, batch number HC 961324;

[0012] (2) Nitric acid (Nitric acid): HPLC grade, Merck Company, batch number K40748356004;

[0013] (3) Hydrochloride acid: HPLC grade, Merck Company, batch number K39343417841;

[0014] (4) Hydrofluoric acid: superior grade, provided by Sinopharm Chemical Reagent Co., Ltd., batch number 20100520;

[0015] (5) High-purity helium (99.999%): pr...

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Abstract

The invention discloses a new application of tanshinone IIA. Tanshinone IIA is one of main effective components in tanshinone, has a quinoid structure, is easy to be oxidized and reduced, can participate in various biochemical reactions in human body and has various biological activities. Tanshinone IIA has various pharmacological effects, can resist cardiac muscle acute hypoxic injury, resist arrhythmia, improve blood vessel smooth muscle functions, and has protection effect on tissue damage caused by ischemia-reperfusion. According to the invention, tanshinone IIA can reduce the arsenic content in body blood. Arsenic is a toxic substance with severe harm to human body. Research shows that when compared with a blank control group, rats administrated with tanshinone IIA have obviously reduced arsenic concentration in blood.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and in particular relates to the effect of tanshinone IIA in reducing the arsenic content in the blood of the body. Background technique: [0002] Arsenic exists widely in nature and is widely used in industrial and agricultural production. It is a toxic substance that is seriously harmful to the body. Arsenic is a protoplasmic poison, which is easy to combine with the sulfhydryl group in the enzyme system in the tissue cells, thereby inhibiting the activity of the enzyme, causing cell metabolism disorders, and forming toxicity to the central nervous system, cardiovascular system, and gastrointestinal system, causing oral, esophagus, and stomach. Mucosa erosion, swelling and bleeding, toxic hepatitis, subacute yellow liver atrophy, fatty infiltration of the heart, central nervous system hypoxia, glomerular injury, etc. In recent years, endemic arsenic poisoning at home and abroad has been seri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P39/02
Inventor 李禄金盛玉成杨娟石劲敏许羚王鲲何迎春陈君超吕映华郑青山刘红霞
Owner SHANGHAI UNIV OF T C M
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