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Medicinal composition for treating vagina inflammatory diseases in gestation period

A composition and drug technology, applied in the direction of drug combination, antibacterial drugs, anti-infective drugs, etc., can solve the problem of unapproved combination administration

Active Publication Date: 2012-11-28
XIAMEN JIAOBAOYUAN BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] For the above three types of vaginal inflammation during pregnancy, the effect of systemic medication is ideal, but due to various concerns of doctors and patients, local medication is often used for pregnancy medication, and combined administration is not approved

Method used

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  • Medicinal composition for treating vagina inflammatory diseases in gestation period
  • Medicinal composition for treating vagina inflammatory diseases in gestation period
  • Medicinal composition for treating vagina inflammatory diseases in gestation period

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Pharmaceutical composition for vaginal inflammation during pregnancy

[0048] Cloves 200 parts by weight

[0049] Psoralen 200 parts by weight

[0050] Moutan bark 200 parts by weight

[0051] Honeysuckle 150 parts by weight

Embodiment 2

[0052] Example 2 Extraction process of pharmaceutical composition for vaginal inflammation during pregnancy

[0053] 1) Extraction of clove oil and paeonol mixture:

[0054] Soak 200 parts by weight of cloves and 200 parts by weight of peony cortex with 12 times the amount of water for 0.5 hours, heat, extract by steam distillation, collect 8 times the amount of distillate, separate oil from water, separate the oil, and dry using anhydrous sodium sulfate After that, 22 parts by weight of the mixture of clove oil and Cortex Moutan are obtained;

[0055] 2) Extraction of medicinal materials:

[0056] ① Merge the clove and Moutan cortex dregs from which clove oil and paeonol have been extracted, 200 parts by weight of psoraleae, and 150 parts by weight of honeysuckle, and use 50 volume % ethanol to heat and extract 3 times at a temperature of 60 ° C. After 2 hours, filter and combine the filtrate;

[0057] ②Concentrate the filtrate under reduced pressure at 60°C under 0.1MPa,...

Embodiment 3

[0060] Embodiment 3 uses the pharmaceutical composition of embodiment 2 to prepare suppository

[0061] 1) Weigh 100 parts by weight of semi-synthetic fatty acid glyceride (type 36), heat to 70-75°C to melt, add 150 parts by weight of powder b at 50°C, keep warm, stir, and mix evenly;

[0062] 2) Pour the mixed liquid into a plug mold coated with liquid paraffin lubricant and sterilized with 75% ethanol while it is hot, cool to form, take it out from the mold, wrap it in wax paper and put it in a plastic box, weighing 5g / grain , and store in a dry and cool place (below 30°C).

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Abstract

The invention provides a medicinal composition for treating vagina inflammatory diseases in a gestation period, and the method comprises the following components in parts by weight: 10 to 200 parts of clove, 10 to 200 parts of fructus psoraleae, 10 to 200 parts of peony root bark, and 10 to 200 parts of honeysuckle. The extraction method of active components comprises the following steps: distilling steam of the clove and the peony root bark to extract a mixture of clove oil and paeonol; 2) combining the clove and peony root bark dreg and rest drugs, heating and extracting by using an alcohol extraction method, concentrating the extract, and drying to prepare powder a; and 3) spraying the mixture of clove oil and paeonol into the powder a to prepare powder b. The powder b and proper excipient are combined to prepare suppository, lotion and oral preparations. The medicinal composition is suitable for a whole body and local part combined administration to treat vagina inflammatory diseases in a gestation period, is exact in curative effect and high in safety, has certain tonifying effect on pregnant women, and has the advantages of less adverse response and high patient compliance.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for vaginal inflammation during pregnancy. Background technique [0002] Common vaginal inflammations during pregnancy include vulvovaginal candidiasis (VVC), bacterial vaginosis (BV) and trichomonas vaginitis. [0003] 1 Vulvovaginal candidiasis Increased estrogen during pregnancy provides a high concentration of glycogen for the growth of local candida in the vagina, and estrogen can also increase the ability of candida to adhere to the epithelial cells of the vaginal mucosa. There are estrogen receptors on the surface of Candida, and Candida binds to estrogen, and estrogen increases the formation of Candida hyphae, thereby increasing the virulence of Candida. Therefore, pregnant women are more likely to be combined with VVC, leading to higher vaginal candida carrier rate and higher incidence of VVC, the highest incidence of VVC in late pregnancy, an...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/02A61P15/02A61P31/04A61P31/10A61P33/02
Inventor 苏建丽
Owner XIAMEN JIAOBAOYUAN BIOLOGICAL SCI & TECH
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