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Silica/poly(methyl methacrylate-styrene) double-layered composite microsphere and its preparation method

A technology of methyl methacrylate and silicon dioxide, which is applied in the field of silicon dioxide/poly double-shell composite microspheres and their preparation, can solve the problem of poor release effect of encapsulated drugs, cumbersome preparation process and low effect. Obvious and other problems, to achieve the effect of release and treatment effect, simple process, easy molecular weight

Inactive Publication Date: 2014-07-02
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the effect is not very obvious, most of the cross-linking agents are self-made, the preparation process is cumbersome, the process is complicated, and the release effect of the prepared encapsulated drug is not good

Method used

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  • Silica/poly(methyl methacrylate-styrene) double-layered composite microsphere and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of waterborne polyurethane includes the following raw materials:

[0039] Isophorone diisocyanate IPDI 8.88 parts

[0040] Polypropylene glycol PPG 20 parts

[0041] Dimethylol propionic acid DMPA 1.34 parts

[0042] Hydroxyethyl methacrylate HEMA 2.86 parts

[0043] Triethylamine TEA 1.01 parts

[0044] The specific preparation method is as follows:

[0045] Weigh IPDI and PPG (relative molecular mass: 1000), blow in nitrogen, remove the air in the system, react at 85°C for 3 hours; add DMPA, react at 85°C for 3 hours; cool down to 70°C, add HEMA for capping reaction 3 hours; cool down to 50°C, add TEA to the system for neutralization, stir rapidly and add water to disperse to obtain waterborne polyurethane.

[0046] Preparation of silica / poly(methyl methacrylate-styrene) double-shell composite microspheres comprises the following raw materials:

[0047] Methyl methacrylate MMA 14 parts

[0048] γ-Methacryloxypropyltrimethoxysilane MPS 1.2 parts ...

Embodiment 2

[0059] The raw material and concrete preparation method of preparing waterborne polyurethane are as follows:

[0060] (with embodiment 1)

[0061] The preparation of silicon dioxide / P(MMA-St) double-shell structure composite microspheres comprises the following raw materials:

[0062] Methyl methacrylate MMA 14 parts

[0063] γ-Methacryloxypropyltrimethoxysilane MPS 1.2 parts

[0064] Orthoethyl silicate TEOS 6 parts

[0065] Hexadecane HD 0.8 parts

[0066] Azobisisobutyronitrile AIBN 0.2 parts

[0067] Waterborne polyurethane WPU 1.76 parts

[0068] Styrene St 7 parts

[0069] 80 parts of water

[0070] Concentration of 28% NH 3 ·H 2 O 1.5 parts

[0071] The specific preparation method is as follows:

[0072] (with embodiment 1)

Embodiment 3

[0074] The raw material and concrete preparation method of preparing waterborne polyurethane are as follows:

[0075] (with embodiment 1)

[0076] The preparation of silicon dioxide / P(MMA-St) double-shell structure composite microspheres comprises the following raw materials:

[0077] Methyl methacrylate MMA 12 parts

[0078] γ-Methacryloxypropyltrimethoxysilane MPS 1.2 parts

[0079] Orthoethyl silicate TEOS 6 parts

[0080] Hexadecane HD 0.8 parts

[0081] Azobisisobutyronitrile AIBN 0.2 parts

[0082] Water-based polyurethane WPU 0.88 parts

[0083] Styrene St 12 parts

[0084] 80 parts of water

[0085] Concentration of 28% NH 3 ·H 2 O 1.5 parts

[0086] The specific preparation method is as follows:

[0087] (with embodiment 1)

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Abstract

The invention discloses a silica / poly(methyl methacrylate-styrene) double-layered composite microsphere and its preparation method. According to the preparation method, self-made aqueous polyurethane is used as a surfactant, a double in situ miniemulsion method is adopted, in-situ hydrolysis of ethyl orthosilicate and in-situ polymerization of methyl methacrylate are utilized, and a second monomer styrene is subsequently added drop by drop so as to prepare the silica / poly(methyl methacrylate-styrene) double-layered composite microsphere. The method provided by the invention has a simple technology, is easy to operate, requires a mild reaction condition and is easy to control. Particles obtained are uniform in size. In addition, the mononuclear double-layered composite microsphere can be obtained by changing the additive amount of aqueous polyurethane and contents of monomer methyl methacrylate and styrene.

Description

technical field [0001] The invention belongs to the field of nanocapsules, in particular to silicon dioxide / poly(methyl methacrylate-styrene) double-shell composite microspheres and a preparation method thereof. Background technique [0002] At present, the small molecule surfactants commonly used in emulsion polymerization have many shortcomings. For example, although this type of surfactant has a certain emulsifying effect, it will play a role in the stage of requiring surfactant during emulsion polymerization. It will not play a role in the later non-essential stage, and the residual surfactant may cause environmental problems, and the free surfactant contained in the final product may even have some negative effects on the performance of the product, which limits the application range of the final product . As a new type of polymerizable surfactant, water-based polyurethane is becoming more and more popular. It uses the condensation reaction between isocyanate and hydro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/14C08F212/08C08F230/08C08F283/00C08F2/44C08F2/24C08G18/67C08K3/36A61K47/32A61K9/51
Inventor 杨建军吴庆云张建安吴明元杨文龙
Owner ANHUI UNIVERSITY
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