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Coaxial nested type multi-mode ion source

A multi-mode, ion source technology, applied in the field of mass spectrometry ion sources, can solve the problems of simultaneous ionization of samples in multiple states, limited application range, and inability to meet rapid detection, etc.

Inactive Publication Date: 2015-06-17
王利兵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, neither the DESI nor the ELDI ionization source can achieve simultaneous ionization of samples in multiple states (such as gaseous samples, liquid samples), and cannot meet the purpose of rapid detection by mass spectrometry, so its application range is limited

Method used

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  • Coaxial nested type multi-mode ion source

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Multi-mode ion source with coaxial nested structure

[0021] as attached figure 1 As shown, the present invention is a novel ion source device coaxially nested by an electron bombardment ion source and an electrospray ion source, wherein electron bombardment ionization-related accessories are located inside the mass spectrometry vacuum chamber (15), and the filament (11 ), an anode (12), a repeller (10), an electric lens group (14), a quartz capillary column (1) and a bombardment ionization chamber (13); the electrospray needle (4) is located in the spray chamber (5) , the spray chamber (5) is located directly in front of the front end of the mass spectrometer vacuum chamber (15); another small opening (2) is opened at the position opposite to the entrance of the spray chamber (5) to the quartz capillary column (1), so that the quartz capillary column ( 1) It can enter the spray chamber (5); the stainless steel capillary conduit (6) is located in front of th...

Embodiment 2

[0022] Example 2: Electron bombardment ionization working mode

[0023] Such as figure 1 As shown, the gaseous compound to be tested enters the quartz capillary column (1) with the helium flow, and passes through the opening (2) of the spray chamber (5) and the capillary inlet located at the center of the injection cone (7) in the mass spectrometry vacuum chamber (15) (3) ( figure 2 ) and two parallel sampling cones (9) reach the bombardment ionization chamber (13); the vacuum degree of the bombardment ionization chamber (13) reaches 10 -4 below pa, the voltage applied to the filament (11) at this time emits an electron beam with an energy of 70 eV, which collides with the sample molecules in the vertical direction and breaks them into charged fragments of different masses; charged fragment ions Under the action of the repeller (10), it is pushed into the electric lens group (14), modulated by the electric lens group (14) to form an electron bombardment ion beam current an...

Embodiment 3

[0025] Example 3: Electrospray ionization mode

[0026] Such as figure 1 As shown, after the liquid sample is injected into the electrospray nozzle (4), a high-voltage direct current is applied to the electrospray nozzle (4) to ionize the outflowing droplets, and the charged droplets are rapidly atomized and removed in the spray chamber (5). Solvation, and then the charged ions are input into the mass spectrometry vacuum chamber (15) through the stainless steel capillary tube (6) passing through the capillary inlet (3); after the electrospray ions are desolvated by two parallel sampling cones (9), It passes through the area where the electron bombardment source is located and enters the subsequent modulation device, which is modulated to form an electrospray ion beam, and finally input into the mass analyzer for mass analysis.

[0027] At this time, the electron bombardment ion source stops working and is in a standby state.

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Abstract

The invention provides a coaxial nested type multi-mode ion source, which is characterized by being formed by coupling and nesting an electron impact ion source and an electrospray ion source, which are arranged on the same sample injection cone axis. An electron impact ionization function and an electrospray ionization function can be independent relatively, so that the electron impact ionization function can be only enabled to analyze a gas sample, or only the electrospray ionization function can be enabled to analyze a liquid sample; and the electron impact ionization function and the electrospray ionization function can be used for analyzing the same sample in different ionization manners simultaneously, or can be used for analyzing two different samples simultaneously, so as to research molecular ion reaction mechanisms of the two different samples. The corresponding working modes of the electron impact ionization function and the electrospray ionization function respectively are an electron impact mode, an electrospray mode and an electron impact-electrospray mode; and the ion source can be automatically and rapidly switched among the three working modes. With the adoption of the coaxial nested type multi-mode ion source provided by the invention, an electron impact-electrospray integrated multi-mode ionizing method is realized possibly. The coaxial nested type multi-mode ion source has the advantages of compact structure, sufficient ionization, multiple purposes and the like.

Description

technical field [0001] The invention belongs to the technical field of mass spectrometry ion sources, and in particular relates to a coaxial nested electron bombardment composite electrospray multi-mode multifunctional mass spectrometry ion source technology. Background technique [0002] In mass spectrometers, the ionization of organic compounds and biomolecules is a key factor that restricts the sensitivity of mass spectrometers. Since the birth of the mass spectrometer, people have carried out continuous research on the ionization technology of compounds. At present, there are four main types of ionization technologies used in mass spectrometers. The four types of ionization technologies can ionize almost all gaseous, liquid and solid molecules that exist in nature. Among them, electron impact ionization (EI) technology and electrospray ionization (ESI) technology are the two most commonly used compound ionization technologies. [0003] Electron bombardment ionization a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/16
Inventor 王利兵丁利清江于艳军胥传来侯尧
Owner 王利兵
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