Application of Chinese aralis bark total saponins in antitumor

The technology of total saponins and Radix Radix Papillae, applied in the application field of anti-tumor, can solve the problems such as limited curative effect, large toxic and side effects, lack of treatment means, etc., and achieve the effect of significant curative effect and small toxic and side effects.

Inactive Publication Date: 2012-12-19
陕西医药控股集团新药技术开发有限公司
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Problems solved by technology

At present, people lack effective treatment methods for the treatment of most tumors. Common methods such as radiotherapy, chemotherapy, and surgery usually have relatively toxic side effects or limited efficacy.

Method used

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  • Application of Chinese aralis bark total saponins in antitumor
  • Application of Chinese aralis bark total saponins in antitumor
  • Application of Chinese aralis bark total saponins in antitumor

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0026] 1. Materials and Instruments

[0027] 1.1 Drugs: The total saponins of Aralia alba extract from the bark of the seven roots of the flying centipede, prepared to an appropriate concentration with deionized water before use.

[0028] The extraction of the total saponins of Aralia alba is as follows: the root bark of Aralia japonica is soaked in ethanol-water solution and heated to reflux for extraction, the extract is loaded on the D-101 resin column, eluted with water until the effluent is colorless, and then ethanol-water solution gradient eluting, collecting eluted fractions, recovering ethanol, and then extracting with ethyl acetate, drying the ethyl acetate extract to obtain total saponins of Aralia alba. The active ingredients of the total saponins of Aralia alba in anti-tumor dis...

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Abstract

The invention discloses an application of Chinese aralis bark total saponins in antitumor, wherein the Chinese aralis bark total saponins have small toxic side effects and a substantial tumor curing effect. The Chinese aralis bark total saponins have a certain inhibition effect on mouse S180 sarcomas, the H22 liver cancer and the mouse leukemia, wherein the IC50 of B16 and the IC50 of FBL3 are 0.0774g / L and 0.199g / L respectively, and the H22 cell inhibition rate of the Chinese aralis bark total saponins in a concentration range of 0.025-3.2g / mL is above 80%. The mouse S18 sarcoma inhibition rates of the Chinese aralis bark total saponins of 100mg.kg<-1>, 200mg.kg<-1> and 300mg.kg<-1> through the gavage to mice are 16.9%, 37.1% and 27.0% respectively; and the H22 liver cancer inhibition rates of the Chinese aralis bark total saponins of same dosages are 23.7%, 10% and 13.4% respectively.

Description

technical field [0001] The invention belongs to the technical field of antitumor drugs, and relates to the antitumor application of total saponins of Aralia alba. Background technique [0002] Malignant tumor is one of the four major chronic non-infectious diseases that seriously affect human health, and it is the second cause of human death. At present, people lack effective treatment methods for the treatment of most tumors. Common methods such as radiotherapy, chemotherapy, and surgery usually have relatively toxic side effects or limited efficacy. Therefore, there is an urgent need to find antitumor drugs with good curative effect and few side effects. Among them, antitumor active substances discovered from natural products are a better way. [0003] The Qinba Mountains are one of the areas with the richest natural medicine resources in my country. Some of the active ingredients extracted from certain Chinese herbal medicines in the Taibai Mountains in the Qinba Mountai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61P35/00A61P35/02A61K31/675
Inventor 封卫毅郑巧伟肖志强杨建刚倪亚会孟祥海
Owner 陕西医药控股集团新药技术开发有限公司
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