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Six-ingredient clove tablet and preparation technology thereof

The technology of clove and Tibetan wood is applied in the field of medicine, which can solve the problems of low bioavailability, slow disintegration rate of water-flavored pills, long retention time in the stomach, etc., and achieves the effects of stable quality of finished products and feasible preparation process.

Active Publication Date: 2013-01-09
青海普兰特药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, it solves the shortcomings of slow disintegration speed, long residence time in the stomach and low bioavailability of Shuifan pills.

Method used

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  • Six-ingredient clove tablet and preparation technology thereof

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Effect test

preparation example Construction

[0019] The preparation technology of described liuwei clove tablet, comprises the following steps:

[0020] 1) According to the formula described in claim 1, weigh cloves, Tibetan woody incense, travertine, licorice, gentian, and myrobalan, select and clean, dry, pulverize, and pass through a 100-mesh sieve;

[0021] 2) Add the crushed medicinal material powder in step 1) into the mixer and mix for 40-60 minutes;

[0022] 3) Stir the medicinal materials mixed in step 2, and add 5% of the adhesive to knead them into a dough. Press lightly and the wet soft materials will disperse. Press the soft materials through a 18-mesh sieve to collect the wet granules and flatten them. After spreading, put it to dry at 75°C, and then use 18-mesh sieve to granulate;

[0023] 4) Press raw powder into tablets, polish and pack.

[0024] herbs Formulation Example 1 Formulation Example 2 Formulation Example 3 clove 5 5.25 6 Tibetan woody fragrance 14 10.51 10 ...

Embodiment 1

[0042] The determination of embodiment 1 basic technology

[0043]Raw material pretreatment and crushing fineness: Liuweijiedu pills are composed of two basic materials: botanical medicine and minerals. According to the production process requirements of Shuifan Pills, the raw medicinal materials must be processed according to the medicinal material standards, and should be crushed into fine powder required by the preparation, and sieved through No. 6 (100 mesh) sieve powder. The fineness meets the tablet raw powder Preparation requirements for tableting (the raw powder is too thick, it is not easy to bond, and the tablet is easy to loose, the raw powder is too fine, the density is high, and the air cannot be discharged in time during tableting, resulting in loosening). It is determined to retain the original processing method, the raw medicinal materials are all pulverized by a pulverizer, and the fine powder passing through the No. 6 sieve is collected for the next step of...

Embodiment 2

[0048] The research of embodiment 2 preparation forming technology

[0049] Chinese herbal medicine tablets are generally granulated from raw powder or powder paste and then compressed into tablets. Whether the quality requirements of tablets are met after compression molding depends on the selection of material properties and granulation process conditions. Because this product is a six-flavor raw material medicine powder used as medicine, and contains two kinds of raw material medicines of plants and minerals, so the mixing uniformity of this product, the binder for granulation, and the fluidity of the granules have been studied.

[0050] Mixing uniformity test: Due to the different densities of the medicinal materials and powders (see Table 1), uniform mixing is the key to ensuring the quality of the finished product. Three batches of materials were tested for mixing uniformity (see Table 2).

[0051] Method: Weigh six raw drug powders according to the prescription amount...

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Abstract

The invention discloses a six-ingredient clove tablet which is characterized in that the traditional Tibetan medicine in the prescription includes clove, Tibet inula root, travertine, liquorice, white gentian and myrobalan which are prepared into the six-ingredient clove tablet. The preparation technology of the six-ingredient clove tablet comprises the steps as follows: 1) weighing clove, Tibet inula root, travertine, liquorice,white gentian and myrobalan based on the prescription; sorting, cleaning, parching, grinding, and sieving with 100 meshes; 2) adding the ground medicine powder in step 1) to a mixing machine for mixing for 40 minutes; 3) agitating the medicine mixed in step 2), and synchronously adding 5% of adhesive, and twisting into blocked moisture soft material which is diffused by being lightly pressed; sieving the soft material through a 18-mesh net; collecting the wet particles; levelly paving; drying at 75 DEG C, and arranging the particles through the sieve with 18 meshes; and 4) tabelleting the raw powder and shaping; and polishing and packaging. The six-ingredient clove tablet disclosed by the invention is mainly used for clearing heat and removing toxicity, and treating swelling and pain in throat, hoarseness and cough.

Description

[0001] technical field [0002] The invention belongs to the technical field of medicine, and relates to a traditional Chinese medicine preparation and a preparation process thereof, in particular to a liuwei clove tablet and a preparation process thereof. Background technique [0003] Liuwei Dingxiang pill is a traditional classic Tibetan medicine Shuipan pill preparation, which has the effect of clearing away heat and detoxifying. It is mostly used for the treatment of sore throat, hoarseness, and coughing diseases. There are many varieties of Tibetan medicine used to treat throat diseases. Liuwei Dingxiang Pills are widely used by patients because of their quick effect, clear curative effect and stability. However, this dosage form has defects such as slow disintegration speed, high hardness, and low bioavailability, and it is urgent to update the dosage form so as to facilitate the use of patients. According to the selection principle of oral preparations of traditiona...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/20A61P11/04A61P11/14G01N21/00G01N30/90G01N30/02
Inventor 代冬海陈长安祝青灿
Owner 青海普兰特药业有限公司
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