Method for extracting catalpol from rehmannia stem

A technology of rehmannia glutinosa and catalpol, applied in the field of medicine, can solve the problems of cumbersome process, high production cost, and high process cost, and achieve the effects of overcoming technical prejudice, saving industrial cost, and reducing the amount of solvent used
CN102863489AInactive Publication Date: 2013-01-09苏州玉森新药开发有限公司
8 Cites 7 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
苏州玉森新药开发有限公司
Publication Date
2013-01-09
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a method for extracting catalpol from rehmannia stem, which belongs to the medicine technical field. The method comprises the following steps: 1) rehmannia stem and water are heated for backflow extraction, an extract is performed pressure reduction and concentration to obtain a concentrate A; 2) 95% of ethanol is added in the concentrate A, standing is carried out for overnight, a supernate is performed pressure reduction and concentration to obtain a concentrate B; 3) a concentrate B is led to a XAD-16 macroporous resin column, elution is carried out by water, then elution is carried out by ethanol, an ethanol eluate is collected, the pressure reduction and concentration are carried out to obtain a stiff paste; 4) silica gel is added in the stiff paste, dried and a silica gel column is added, elution is carried out by ethyl acetate / methanol according to ratio of 4:1, a target fraction is collected, the pressure reduction, concentration and drying processes are carried out; 5) recrystallization is carried out on a dried object, the processes of filtering and drying are carried out to obtain the catalpol pure product. Compared with the prior art, the method of the invention has the characteristics of strong industrialization operationality, high extraction efficiency, resource preservation and environmental protection.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for extracting catalpol from the stem of Chinese medicine rehmannia glutinosa, belonging to the technical field of medicine. Background technique

[0002] In 1962, W.H. Lunn et al. first isolated catalpa glycoside from the fresh fruit of the catalpa tree Catalpa ovata, then hydrolyzed catalpaline, and obtained catalpol after recrystallization of the hydrolyzed product. This is the earliest report of catalpol. In 1965, R.B.Duff et al. used activated carbon and diatomaceous earth as fillers. After multiple column chromatography and finally recrystallized with water, they isolated naturally occurring catalpol for the first time from the leaves of Buddleia globosa.

[0003] In 1971, Kitagawa Isao and others in Japan studied the hypoglycemic components of Rehmannia glutinosa. They separated R-BP-F, an effective component with significant hypoglycemic effect, from Huaiqing Rehmannia glutinosa. Separation by column chromatog...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More