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Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping

A slow-release capsule and antidiarrheal technology, which can be used in capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve the problems of unsatisfactory clinical efficacy and low bioavailability

Inactive Publication Date: 2013-01-23
GUIZHOU BAIHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned extraction method is relatively simple, resulting in a large amount of ineffective ingredients and impurities in the product, and low bioavailability, making its clinical efficacy unsatisfactory

Method used

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  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping
  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping
  • Preparation method of controlled-release capsule with functions of detoxifying and diarrhea stopping

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Recipe: 1000g of opposite sitting leaves.

[0082] Process:

[0083] ①Take the opposite sitting leaves and crush them into the coarsest powder, extract twice with 10 times the amount of 80% ethanol, filter for 2 hours each time, combine the extracts, recover the ethanol, and concentrate to a relative density of 1.10-1.15 at 80°C. Thick ointment; decocting the dregs with 10 times water for 2 times for 1.5 hours each time, filtering and combining the extracts, and the filtrate is concentrated to a thick ointment of 1.10-1.15 at a relative density of 80°C; combining the above thick ointment and mixing, Dry at 80°C, smash through 80 mesh sieve, and set aside;

[0084] ②Take 1 / 3 weight of the powder in ① and add 20% of the powder weight by citric acid: Na 2 CO 3 =11:9 mixed effervescent disintegrant, 70% ethanol is used to make soft material, the speed of the propeller is adjusted to 30r / min, the soft material is extruded by the extruder, and the extrudate is curved under the acti...

Embodiment 2

[0090] Recipe: 1000g of opposite sitting leaves.

[0091] Process:

[0092] ①Take the opposite sitting leaves and crush them into the coarsest powder, extract 3 times with 12 times the amount of 90% ethanol for 1 hour each time, filter, combine the extracts, recover the ethanol, and concentrate to a relative density of 1.10-1.15 at 80°C Thick ointment; decocting the dregs with 12 times water for 3 times, 1 hour each time, filtering and combining the extracts, and the filtrate is concentrated to a thick ointment of 1.10-1.15 at a relative density of 80°C; combining the above thick ointment and mixing, Dry at 80°C, smash through 80 mesh sieve, and set aside;

[0093] ②Take 1 / 3 part by weight of the powder in ① and add 30% by weight of citric acid: Na 2 CO 3 =15:5 mixed effervescent disintegrant, made of soft material with 80% ethanol, adjusted the speed of the propeller to 30r / min, the soft material was extruded by the extruder, and the extrudate was curved under the action of gravity...

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Abstract

The invention discloses a preparation method of a controlled-release capsule with functions of detoxifying and diarrhea stopping. The controlled-release capsule is prepared from scabrid smallhooked hedyotis herb and auxiliary materials. According to the property of the scabrid smallhooked hedyotis herb, an extraction technology is optimized. Furthermore, aiming at the problem that the existing form bioavailability is low, one part of the scabrid smallhooked hedyotis herb is prepared into a quick-release pellet, the other part of the scabrid smallhooked hedyotis herb is prepared into a controlled-release pellet, and the two pellets are filled to prepare the capsule, so that the controlled-release capsule can be taken by patients in both of the acute stage and the chronic stage of colitis gravis, and therefore, the effect of treating both symptoms and root causes can be achieved, and the recurrence of the colitis gravis can be more effectively cured.

Description

Technical field [0001] The invention relates to a preparation method of a detoxification and antidiarrheal slow-release capsule, which belongs to the field of medicine technology. technical background [0002] Based on the understanding of the etiology and pathogenesis of chronic ulcerative colitis (UC), modern medicine mainly adopts anti-inflammatory, antibacterial, and immune response suppression methods. Commonly used drugs include aminosalicylic acids, corticosteroids, and immunosuppressants , Anti-infectives, etc. These drugs have played a positive role in the treatment of UC, but at the same time there are problems such as high recurrence rate, unsatisfactory treatment effect and serious side effects. [0003] Traditional Chinese medicine believes that the disease belongs to the category of diseases such as "intestinal dysentery", "dysentery", and "diarrhea". The clinical use of Baitouweng Decoction, Xianglian Pills and other compound additions and subtractions is often used...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61K9/48A61K9/16A61P1/12
Inventor 黄文荣马静李江
Owner GUIZHOU BAIHUA PHARMA
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