Preparation and application of cellulose nanocrystals (CNCs)-reinforced collagen compound substrate

A nano-microcrystalline and composite matrix technology, which is applied in skin care preparations, cosmetic preparations, dressing preparations, etc., can solve problems such as poor mechanical properties, difficulty in shaping, and inability to support tissue reconstruction, and achieve high production efficiency , Improved mechanical strength, and excellent liquid absorption
CN102886063BActive Publication Date: 2015-04-22JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2015-04-22

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Abstract

The invention discloses a preparation method and an application of a cellulose nanocrystals (CNCs)-reinforced collagen compound substrate, which belong to the field of tissue engineering. The preparation method comprises the following steps of: preparing CNCs by adopting a method for degrading cellulose with sulfuric acid; preparing a CNCs solution and a collagen solution, and mixing the CNCs solution and the collagen solution physically; and pouring the mixed solution into a mold, and molding to obtain the CNCs-reinforced collagen compound substrate. According to the CNCs-reinforced collagen compound substrate prepared with the method, the problems of poor mechanical strength and poor hydrophilicity of the conventional collagen material are solved; and the CNCs-reinforced collagen compound substrate can be applied in the fields of wound dressings, tissue inducing regeneration membranes, soft tissue patches, tissue engineering skin, facial masks and the like. A preparation process technic provided by the invention is easy and practicable, has high repeatability, and is suitable for industrial production of CNCs-reinforced collagen compound substrates of different requirements.
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Description

technical field

[0001] The invention belongs to the field of tissue engineering and relates to a collagen matrix, in particular to the preparation and application of a nano-microcrystalline cellulose-reinforced collagen composite matrix. Background technique

[0002] Collagen is the main component of the extracellular matrix and the most abundant structural protein in the human body, accounting for about 25% to 35% of the total protein in the body, mainly found in connective tissue. Because of the high content of collagen, connective tissue has certain structural and mechanical properties, such as tensile strength, tension, elasticity, etc., to achieve the functions of support and protection.

[0003] Collagen has good biocompatibility, nutrition, repair, moisturizing, compatibility and affinity, so it is widely used in functional products such as biomedical materials, cosmetics, food and health products. Collagen has the functions of beauty (anti-wrinkle, moisturizing, whi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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