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Preparation method of calcium-containing soluble hemostatic material

A hemostatic material and soluble technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of unsuitability for large-scale production, large ethanol, high production cost, etc., and achieve suitable for large-scale production, mild process conditions, and safe production process Effect

Active Publication Date: 2013-01-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex process, long reaction time, high production cost, poor hemostatic effect, and insufficient safety of raw materials, it cannot be mass-produced and widely used.
For example, in the production process of Chinese patents CN1232236C and CN1047976, the reaction time is more than 10 hours, and more than 80% ethanol solution is used for washing in the washing process, which consumes a large amount of ethanol, and the production cost is high, so it is not suitable for large-scale production.
Patent CN186490 discloses a hydroxyethyl modified cotton fiber fabric and its preparation method. Ethylene oxide is used in the production. This raw material has active chemical properties and reacts violently with cotton fiber fabric, which is prone to explosion. The reaction must be It is carried out slowly under vacuum conditions, and there are certain safety hazards in the production process. The reaction time needs to be 20-24 hours, and the production efficiency is low.

Method used

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  • Preparation method of calcium-containing soluble hemostatic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Wind the selected polysaccharide fiber layer by layer on the instrument, and immerse it in the ethanol aqueous solution of sodium hydroxide. The content of sodium hydroxide in the ethanol aqueous solution of sodium hydroxide is 60g / L, and the volume ratio of ethanol to water 80%, bath ratio (mass ratio of polysaccharide fiber to ethanol aqueous solution of sodium hydroxide) is 1:20, control the reaction liquid in the instrument to flow continuously, and alkalize for 1h.

[0027] (2) After alkalization is completed, add chloroacetic acid and etherify at 60°C for 1 hour.

[0028] (3) After the etherification is completed, remove the solution on the polysaccharide fiber, put it into the alcoholic aqueous solution of calcium chloride, the mass percentage concentration of calcium chloride in the alcoholic aqueous solution of calcium chloride is 0.5%, and the volume of alcohol and water The ratio is 30%, and the ion exchange reaction takes 20 minutes.

[0029] (4) After ...

Embodiment 2

[0032] (1) After the etherification is completed, remove the solution on the polysaccharide fiber, put it into the alcoholic aqueous solution of calcium chloride, the mass percentage concentration of calcium chloride in the alcoholic aqueous solution of calcium chloride is 1%, and the volume of alcohol and water The ratio is 30%, and the ion exchange reaction takes 20 minutes.

[0033] (2) Wash 2 to 3 times with 30% ethanol by volume, wash off the salt generated by the reaction, and dry with hot air.

[0034] (3) The remaining procedures are the same as in Example 1.

[0035] The calcium content of the prepared calcium-containing soluble hemostatic material reaches more than 0.1% (w / w), and the alcohol washing step can save 40-50% of ethanol compared with the existing patent.

Embodiment 3

[0037] (1) After the etherification is completed, remove the solution on the polysaccharide fiber, put it into the alcoholic aqueous solution of calcium chloride, the mass percentage concentration of calcium chloride in the alcoholic aqueous solution of calcium chloride is 2%, and the volume of alcohol and water The ratio is 30%, and the ion exchange reaction takes 10 minutes.

[0038] (2) Wash 2 to 3 times with 30% ethanol by volume, wash off the salt generated by the reaction, and dry with hot air.

[0039] (3) The remaining procedures are the same as in Example 1.

[0040] The calcium content of the prepared calcium-containing soluble hemostatic material reaches more than 0.1% (w / w), and the alcohol washing step can save 40-50% of ethanol compared with the existing patent.

[0041] The polysaccharide fibers used in the above examples are preferably cotton, hemp, chitosan, etc., and the prepared calcium-containing soluble hemostatic material can be made into medical dressin...

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Abstract

The invention discloses a preparation method of calcium-containing soluble hemostatic material. The calcium-containing soluble hemostatic material takes polysaccharide fiber as a raw material and is prepared by alkalization, etherification, calcification, alcohol washing and the like. The preparation method is mild in preparation conditions and short in production period which is about 2-3hours. The calcium-containing soluble hemostatic material has rapid hemostatic effect and adopts low-concentration alcoholic solution for washing; and compared with the prior art, the calcium-containing soluble hemostatic material saves 40-50% of alcohol and uses the low-concentration alcohol, thus production technology is simple and suitable for large-scale production.

Description

technical field [0001] The invention relates to a preparation method of a medical dressing, in particular to a preparation method of a calcium-containing soluble hemostatic material. Background technique [0002] At present, medical dressings are generally sterilized with absorbent cotton gauze for use by medical and health departments. This kind of medical dressing has poor blood-absorbing and hemostatic capabilities, especially for treating chronic wounds with pus and blood exudates. After being absorbed by the dressing, it is mainly absorbed in the capillary space between fibers. The liquid will spread along the structure of the fabric, bringing pus and blood from the wound to the healthy skin around the wound, causing impregnation of the wound edge, and in severe cases, the wound will Expansion; when the gauze is replaced or removed, it is easy to stick, destroy the newly grown tissue, and become waste after use, which is not easy to rot. Therefore, since the 1940s, med...

Claims

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Application Information

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IPC IPC(8): A61L15/62A61L15/28
Inventor 赵昔慧李群密叶
Owner QINGDAO UNIV
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