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Celangulin TC, its preparation method and quality detection method

A quality detection method and the technology of picolin, applied in the field of botanical pesticides

Active Publication Date: 2013-01-30
河南省科高植物天然产物开发工程技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems existing in the prior art and quality of botanical pesticides, the object of the present invention is to provide a good botanical pesticide picroderm and its aqueous emulsion

Method used

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  • Celangulin TC, its preparation method and quality detection method
  • Celangulin TC, its preparation method and quality detection method
  • Celangulin TC, its preparation method and quality detection method

Examples

Experimental program
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Effect test

preparation example Construction

[0092] 1. The preparation method of the former medicine of picroderm and emulsion in water

[0093] (1) 35% bitter bark vine raw medicine

[0094] Weigh the shade-dried bitter vine root or / and bark and crush it (pass through a 10-24 mesh sieve), add 2-6 times the volume, 90-95% ethanol, reflux or ultrasonically extract 2-3 times at 60-80°C , extracted for 1-2 hours each time, combined the filtrate after filtration, concentrated under reduced pressure; took the concentrated filtrate (density 0.90-1.19), packed it into a column with 1-2 times its weight of macroporous adsorption resin, and successively washed it with 20~25% ethanol, 40~50% ethanol, 75%~85% ethanol and 90~95% ethanol were washed into the column, and the 75%~85% ethanol eluate was collected, and evaporated to dryness under reduced pressure to obtain the original phalloidin medicine. The model of the macroporous adsorption resin is HP-20, D-101, D-201 or SP-70; the diameter-to-height ratio of the macroporous adso...

Embodiment 1

[0247] (1) Preparation method of 35% T9 picrodermin original drug A

[0248] After sieving, the root and bark of Phyllostachys chinensis that meet the requirements (24 meshes) are sequentially added to ethanol with a volume of 3:2:2 times and a mass ratio of 95%, and reflux extraction at 80°C for 3 times, each time for 2 hours, Filtrate, combine the three filtrates, and concentrate under reduced pressure to a filtrate with a density of 0.95. Get the filtrate, use its weight as 1 times the amount of HP20 resin packing column (diameter-height ratio: 10:1), successively wash the column with 20% ethanol, 40% ethanol, 80% ethanol and 95% ethanol (the ethanol for punching the column 25, 30, 40 and 20 times the volume of the filtrate after concentration respectively), collect the 80% ethanol eluate, evaporate to dryness under reduced pressure, and obtain 35% T9 picroderine original drug A.

[0249]

[0250] (2) 35%T9 picrodermin original drug A quality testing method

[0251] ①P...

Embodiment 2

[0268] (1) The preparation method of 35% T9 picrodermin original drug B

[0269] After sieving, the roots and bark of the bitter vine that meet the requirements (24 meshes) are sequentially added to ethanol with a volume of 3:3:3 times and a mass ratio of 95%, and reflux extraction at 60°C for 3 times, each extraction for 1.5h , filtered, combined three filtrates, and concentrated under reduced pressure to a filtrate with a density of 1.09. Take the filtrate, pack it into a column (diameter-to-height ratio: 10:1) with twice its weight of D-101 resin, and successively wash the column with 25% ethanol, 50% ethanol, 85% ethanol and 90% ethanol (punch the column 25, 30, 40 and 20 times the volume of the ethanol after concentrating the filtrate respectively), collect the 85% ethanol eluate, and evaporate to dryness under reduced pressure to obtain 35% T9 pharethin original drug B.

[0270]

[0271] (2) 35%T9 phatericin original drug B quality detection method

[0272] ①Prepara...

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Abstract

The invention relates to a celangulin TC and its emulsion in water, its preparation method and quality detection method. The celangulin TC comprises the following active ingredients: 6.0-9.5wt% of angulatin A, 7.5-9.5wt% of angulatin B, 4.0-6.5wt% of angulatin C and angulatin F, 6.5-10.5wt% of angulatin G, 11.5-15.5wt% of angulatin A, angulatin E, angulatin C and angulatin XIX, and 3.5-6.0wt% of angulatin H. The celangulin TC is prepared by macroporous adsorption resin. IGD C nuclear magnetic resonance coupling fingerprint technology is used in the quality detection method. According to the invention, the content of the celangulin is greatly raised, and the accuracy, stability, repeatability and feasibility of the quality detection method are high.

Description

technical field [0001] The invention belongs to the technical field of botanical pesticides, and in particular relates to an original medicine of picroderm and its emulsion in water, as well as their preparation method and quality detection method. Background technique [0002] Celastrus angulatus MaXim is a perennial vine-like shrub of Celastraceae (Celastraceae), distributed in Hebei, Shandong, Henan, Shaanxi, Hubei, Gansu, Jiangsu, Anhui and other provinces [Chinese Academy of Sciences Flora of China Editorial Committee. Flora of China. Science Press, 1999,45(3):102]. Bittervine is a traditional insecticidal plant in my country. Its roots and skins are used as natural non-toxic insecticides for vegetables and other crops, so it is named "vegetable medicine" and "radish medicine". Research has proved that the biologically active ingredients contained in it Mainly β-dihydro agarwood furan polyol ester compounds and their alkaloids, these compounds generally have strong inse...

Claims

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Application Information

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IPC IPC(8): A01N43/12A01N25/04A01P7/04G01N24/08G01N30/02
Inventor 张海艳赵天增董建军于立芹刘雨晴范毅郭唯常霞王伟魏悦王涛
Owner 河南省科高植物天然产物开发工程技术有限公司
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