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Medicine composition for treating acnes as well as preparation method and application thereof

A composition and drug technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., to avoid high cost and uneven mixing, ensure stability, and avoid degradation.

Inactive Publication Date: 2013-01-30
江西蓝十字生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, also do not see the report that clindamycin phosphate and benzoyl peroxide prepare microemulsion gel simultaneously

Method used

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  • Medicine composition for treating acnes as well as preparation method and application thereof
  • Medicine composition for treating acnes as well as preparation method and application thereof
  • Medicine composition for treating acnes as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prescription composition:

[0036] Benzoyl Peroxide / Clindamycin Phosphate Microemulsion

[0037]

[0038] blank gel

[0039]

[0040] Preparation Process:

[0041] 1. Weigh 2.5g of benzoyl peroxide and disperse in 10.0g of capric acid triglyceride oil phase; mix 10.0g of lecithin and 5.0g of glycerin evenly, add to the oil phase, mix well, and set aside; Take 1.2 g of clindamycin phosphate, dissolve it in the prescribed amount of water, slowly drop it into the oil phase under stirring conditions, and stir until a uniform and transparent benzoyl peroxide / clindamycin phosphate microemulsion is obtained;

[0042] 2. Weigh 0.3g of carbomer, slowly add it into 15g of water under stirring condition, after fully swelling, add water to 20g, mix well, and get blank gel;

[0043] 3. Mix the microemulsion and blank gel evenly, add potassium hydroxide to adjust the pH to 5.0-7.0, and obtain 2.5% benzoyl peroxide / 1.2% clindamycin phosphate microemulsion gel.

Embodiment 2

[0045] Prescription composition:

[0046] Benzoyl Peroxide / Clindamycin Phosphate Microemulsion

[0047]

[0048] blank gel

[0049]

[0050] Preparation Process:

[0051] 1. Weigh 5.0g of benzoyl peroxide and disperse in 10.0g of isopropyl palmitate oil phase; mix 15.0g of Tween and 8.0g of propylene glycol evenly, add to the oil phase, mix well, and set aside; Take 2.5 g of clindamycin phosphate, dissolve it in the prescribed amount of water, slowly drop it into the oil phase under stirring conditions, and stir until a uniform and transparent benzoyl peroxide / clindamycin phosphate microemulsion is obtained;

[0052] 2. Weigh 0.3g of carbomer, slowly add it into 15g of water under stirring condition, after fully swelling, add water to 20g, mix well, and get blank gel;

[0053] 3. Mix the microemulsion and blank gel evenly, add potassium hydroxide to adjust the pH to 5.0-7.0, and obtain 5.0% benzoyl peroxide / 2.5% clindamycin phosphate microemulsion gel.

Embodiment 3

[0055] Prescription composition:

[0056] Benzoyl Peroxide / Clindamycin Phosphate Microemulsion

[0057]

[0058] blank gel

[0059]

[0060] Preparation Process:

[0061] 1. Weigh 5.0g of benzoyl peroxide and disperse it in 8.0g of isopropyl myristate oil phase; mix 13.0g of Span and 3.0g of ethanol evenly, add to the oil phase, mix well, and set aside; Take 2.5 g of clindamycin phosphate, dissolve it in the prescribed amount of water, slowly drop it into the oil phase under stirring conditions, and stir until a uniform and transparent benzoyl peroxide / clindamycin phosphate microemulsion is obtained.

[0062] 2. Weigh 0.5g of gelatin and 3.0g of glycerin and slowly add it to 15g of water under stirring condition. After fully swelling, add water to 20g and mix evenly to obtain a blank gel;

[0063] 3. Mix the microemulsion and blank gel evenly, add triethanolamine to adjust the pH to 5.0-7.0, and obtain 5.0% benzoyl peroxide / 2.5% clindamycin phosphate microemulsion gel...

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PUM

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Abstract

The invention provides a medicine composition for treating acnes. The medicine composition is microemulsion-based gel prepared from such active ingredients as benzoperoxide and clindamycin phosphate. The invention also provides a preparation method and an application of the medicine composition. After clindamycin phosphate and benzoperoxide are prepared into the microemulsion-based gel, though the two ingredients are still contacted in the mixed preparation, the preparation can effectively avoid degradation of the two ingredients, thus not only ensuring the stability of the medicine but also avoiding the defects of high cost and nonuniform mixture caused by independent packaging and providing a new choice for clinical use of the medicine.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating acne, its preparation method and application. Background technique [0002] Acne is a common skin disease, mostly occurs in puberty, also known as comedo, acne. There are various factors that cause acne, but the most direct factor is pore blockage. After the pores are blocked, the oil in the hair follicle cannot be discharged. Because the hair follicle opening is blocked, the hair follicle lumen is narrow, forming a hypoxic state, which makes the hair follicles tired. A large number of oxygen bacteria proliferate, leading to microbial imbalance, the human body activates inflammatory mediators, acne turns red, and acne is formed. [0003] There are a variety of preparations for the treatment of acne, most of which are benzoyl peroxide alone or in combination with some antibiotics, but there is an irritation problem when using benzoyl peroxide alone, which can cause redness of the skin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/327A61K9/00A61P17/10
Inventor 林山何达王松何宇新孙小伟
Owner 江西蓝十字生物科技有限公司