Preparation method of 2-(3-aminophenyl) imidazoline hydrochloride

A technology of imidazoline hydrochloride and aminophenyl, which is applied in the field of preparation of 2-imidazoline hydrochloride, can solve the problems of limited industrial production scale, difficult separation of material and liquid, complicated preparation process and the like, and achieves good industrialization prospects , Overcome the cumbersome operation and the effect of environmental friendliness
CN102898375AActive Publication Date: 2013-01-30QILU ANIMAL HEALTH PROD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QILU ANIMAL HEALTH PROD
Publication Date
2013-01-30

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Abstract

The invention relates to a preparation method of 2-(3-aminophenyl) imidazoline hydrochloride. the method comprises the steps of: adding 2-(3-aminophenyl) imidazoline to a solvent according to a mass-volume ratio of 1:(2-1); then adding palladium carbon with the palladium content of 0.5-10wt% in the proportion of 1-10% of the weight of the 2-(3-aminophenyl) imidazoline; carrying out reducing hydrogenation reaction for 2.5-6 hours under the conditions that the temperature is 10-100 DEG C, the atmosphere is hydrogen and the pressure of 0.01-0.95MPa; filtering, adjusting the pH of a filtrate to be at 1.0-3.0, reducing the temperature to -2-3 DEG C, standing for crystallization for 0.5-2h, filtering to obtain a precipitate, and drying the precipitate to prepare the 2-(3-aminophenyl) imidazoline hydrochloride. The preparation method is easy to control, small in energy consumption, low in cost, environment-friendly, and good in industrialization prospect.
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Description

technical field

[0001] The invention relates to a preparation method of 2-(3-aminophenyl)imidazoline hydrochloride, belonging to the technical field of veterinary drug preparation. Background technique

[0002] 2-(3-Aminophenyl)imidazoline hydrochloride is a necessary intermediate for the preparation of imidazolium. Imidazuron belongs to the derivative of diphenyl urea, which is a new type of anti-protozoal chemical drug specially used for animals. Clinically, its dipropionate or bishydrochloride is commonly used to make preparations, which are injected intramuscularly or subcutaneously to treat and prevent various babesiosis, piriplasmosis, trypanosomiasis, and eperythrocytic disease, borderworm disease and theileriasis, etc.

[0003] U.S. patent document US3338917 discloses the method that 2-(3-aminophenyl) imidazoline dihydrochloride prepares imidazolium hydrochloride, that is, in 2-(3-aminophenyl) imidazoline dihydrochloride aqueous solution, pass into phosgene Conden...

Claims

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